Navigation Links
Team finds promising new drug target for Alzheimer's disease
Date:4/20/2010

CHAMPAIGN, lll. Researchers at the University of Illinois have identified a potential drug target for the treatment of Alzheimer's disease: a receptor that is embedded in the membrane of neurons and other cells.

A protein fragment associated with Alzheimer's disease activates this receptor, sparking increased activity in the affected neurons, eventually leading to cell death, the researchers report. The new findings appear in the FASEB Journal.

Scientists have known for decades that a protein fragment, called amyloid-beta (AM-uh-loyd BAIT-uh), is a key to the riddle of Alzheimer's disease. Alois Alzheimer himself first found aggregates of this "peculiar substance" in the brain of a dementia patient after her death. These bundles of protein, or plaques, are composed almost entirely of amyloid-beta, and still are used to diagnose Alzheimer's disease after death.

Animals with amyloid plaques in the brain experience a decline in brain function that mirrors that of Alzheimer's disease. A recent study found that neurons closest to these plaques tend to be hyperexcitable relative to normal, while activity in the surrounding neurons is depressed, indicating an imbalance in brain activity associated with these plaques.

Other studies have found that clumps of only two, or a few, amyloid-beta fragments somehow stimulate a receptor, called the AMPA receptor. When amyloid-beta binds to a neuron, the AMPA receptor opens a channel that lets calcium or sodium ions into the cell.

Normally the AMPA receptor opens this channel only when it binds to glutamate, a potent neurotransmitter that is important to normal brain function as well as memory and learning. In either case, the quick influx of ions causes a nerve impulse.

To date, scientists have not been able to identify a mechanism by which amyloid-beta causes the AMPA receptor channel to open, however.

"If a mouse is exposed to amyloid-beta in the brain, it
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Given No Chance to Survive with Pancreatic Cancer, Chicago Woman Finds New Life at Northwest Community Hospital
2. Study finds treatment-resistant ringworm prevalent among children in metro elementary schools
3. Convenience drives US women to buy over-the-counter contraception in Mexico, study finds
4. Dance therapy improves seniors gait, balance, researcher finds
5. The Medical Marijuana Industry Finds an Outside-the-Box Solution, "Inside the Box" With GrowOp Technology
6. Statins May Slow Progression of Multiple Sclerosis, New Study Finds
7. Study finds changes in fetal epigenetics throughout pregnancy
8. Statins may slow progression of multiple sclerosis, new study finds
9. Study Finds Military Prone to Infection With H1N1 Flu
10. Eating disorder cutoffs miss some of sickest patients, Stanford/Packard study finds
11. UBC graduate student finds a start/stop switch for retroviruses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds promising new drug target for Alzheimer's disease
(Date:10/1/2014)... October 01, 2014 Lifeinsurance-policy.com has ... the best life insurance prices for smokers. , Smoking ... insurance premiums. Comparing quotes is the best method to ... quotes for customers who need coverage. , Whole ... duration of the policy. Since the coverage is permanent, ...
(Date:10/1/2014)... October 01, 2014 Join the more than ... Disorder Treatment Center’s first ever charity golf tournament to benefit ... with eating disorders who cannot afford treatment. The tournament will ... in Eureka, Mo. , The day-long event starts with ... reception and award dinner will begin at 5 p.m. and ...
(Date:10/1/2014)... Diet Doc understands that many of their ... and their dieting attempts could be easily sabotaged by the ... diet treatments into their programs as a way to ... and effective weight loss results, it also allows patients to ... maintain their weight for the future. , Earlier versions of ...
(Date:10/1/2014)... Dar, Ethiopia, at the occasion of the Leishmaniasis ... 150 African and international leishmaniasis experts, results of ... efficacy monitoring plan, carried out by MSF, ... and Ethiopia, were presented to key decision makers ... of kala-azar with the combination of Sodium Stibogluconate ...
(Date:10/1/2014)... 01, 2014 Today marks the final ... Art Institute in Oxnard and Woodland Hills, Calif., is ... mouth rehabilitation training. , “Speaking to this group of ... procedures to get the help and care they deserve,” ... repairing previous dental work, providing cosmetic dentistry, correcting bite ...
Breaking Medicine News(10 mins):Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... , , Patient-Based Record ... , MADISON, N.J., July 20 MedPlus, the ... DGX ), today announced that NYCLIX is now sharing ... New York City using the company,s Centergy(TM) suite of ...
... , SEOUL, South Korea, July 20 ... to announce that its wholly owned subsidiary, VASKA, a ... institutional, and consumer markets, has successfully turned the first major commercial ... Royal Laundry of South San Francisco is the largest ...
... , , ... campaign in support of bipartisan health care reform. , ... Plans (AHIP), "Illness", calls for fixing health care to make sure all Americans ... , "Illness doesn,t care where you live. . .or if ...
... , , , ... Oldsmar, Fla., July 20 /PRNewswire-FirstCall/ -- Women today have a number ... of their families. Banking stem cells found in menstrual blood is one way ... injuries. Menstrual blood has been shown to contain self-renewing stem cells that may ...
... Calif., July 20 SynergEyes, Inc., the high Dk ... lens design for keratoconus patients. ClearKone(TM) is a revolutionary ... of the hybrid platform, providing superior visual acuity, centration, ... to vault the predominant irregularities of the keratoconic cornea, ...
... , , BRIDGEWATER, ... pooled results from two Phase 3 studies (DUET-1 and ... non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI) ... copies/mL) while taking INTELENCE(TM) (etravirine) tablets plus background regimen ...
Cached Medicine News:Health News:Quest Diagnostics MedPlus Subsidiary Enables New York Clinical Information Exchange (NYCLIX) to Share Meaningful Data and Enhance Patient Care 2Health News:Quest Diagnostics MedPlus Subsidiary Enables New York Clinical Information Exchange (NYCLIX) to Share Meaningful Data and Enhance Patient Care 3Health News:Quest Diagnostics MedPlus Subsidiary Enables New York Clinical Information Exchange (NYCLIX) to Share Meaningful Data and Enhance Patient Care 4Health News:HepaHope Korea Subsidiary VASKA Introduces Green Chemicals to U.S. Commercial Laundry Industry 2Health News:Health Plans Return to Airwaves in Support of Bipartisan Reform 2Health News:C'elle(SM) Featured on ABC Action News in Tampa Bay 2Health News:C'elle(SM) Featured on ABC Action News in Tampa Bay 3Health News:C'elle(SM) Featured on ABC Action News in Tampa Bay 4Health News:C'elle(SM) Featured on ABC Action News in Tampa Bay 5Health News:SynergEyes, Inc. Launches New Hybrid Lens Design for Keratoconus Patients 2Health News:SynergEyes, Inc. Launches New Hybrid Lens Design for Keratoconus Patients 3Health News:96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy 2Health News:96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy 3Health News:96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy 4Health News:96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy 5Health News:96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy 6
(Date:9/30/2014)... health and safety of Canadians is our government,s highest priority.  Our ... at its disposal to help ensure that the drugs Canadians need ... end, Health Canada has taken decisive ... of all drug products from three plants in ... Pharmachem India Pvt Ltd , Apotex Research Private Limited ...
(Date:9/30/2014)... 2014  Tasly Pharmaceuticals, Inc., the world,s leader ... today the launch of Deepure. Deepure ... men and women concerned with supporting their overall ... age while helping keep their health care cost ... herb-based formulas, namely, ProHeart PLUS, ImmunoPower PLUS, and ...
(Date:9/30/2014)... Mass. , Sept. 30, 2014  Decision Resources ... devices in Brazil , ... China (BRIC) will see robust ... are increasingly favored over surgical procedures. Although revenues will ... resources, reimbursement challenges, prolonged device approval times and demand ...
Breaking Medicine Technology:Statement by the Honourable Rona Ambrose on the import ban of drug products from three plants in India 2Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 2Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 3
... magnification and increased stereopsis, the ... for detailed visualization to the ... is ideal for vitrectomy in ... in proliferative vitreoretinopathy extending to ...
... Volks Reinverting Operating Lens System® ... advanced wide angle viewing system ... Its unique single-element prism design, ... wide-field viewing capability have made ...
... The new Volk Blumenthal Suturelysis ... flap sutures, enabling cutting sutures which, ... relatively inaccessible. The lens provides localized ... of the suture 2-3 times, resulting ...
... Laser capsulotomy procedures are now greatly improved ... Lens. This new lens promotes precise and ... bag. Computer optimized for enhanced viewing and ... new aspheric design comes standard with LaserWindow ...
Medicine Products: