Navigation Links
Team finds on-off switch to burning stored fat
Date:6/5/2014

SAN ANTONIO, Texas (June 5, 2014) Scientists this week reported that a molecular pathway called mTORC1 controls the conversion of unhealthy white fat into beige fat, an appealing target for increasing energy expenditure and reducing obesity. The team, led by researchers from the School of Medicine at The University of Texas Health Science Center at San Antonio, also found that a protein, Grb10, serves as the on-off switch for mTORC1 signaling and the "beigeing" of fat.

The finding could inform development of novel diabetes and obesity drugs, the scientists said. The study is reported in this month's issue of Cell Metabolism and was selected as the highlighted featured article.

Heat in response to cold

Grb10 is stimulated by cold stress, which causes the body to burn energy. ""We know that if we want to keep our body lean, we have to get rid of extra nutrients in the body, which means burning more energy," said senior author Feng Liu, Ph.D., professor of pharmacology at the UT Health Science Center and director of the Metabolic Syndrome Research Center at Xiangya Second Hospital, Central South University, in Changsha, China.

"Understanding how beigeing is controlled is so very important because if we can improve energy expenditure, we can reduce obesity," Dr. Liu said.

Undesirable storage

Adipose (fat) tissues, which include white adipose tissue and brown adipose tissue, are important regulators of metabolism. Having too much white adipose tissue and not burning it off through exercise or other energy expenditure is associated with obesity and metabolic diseases such as type 2 diabetes.

"Normally when we eat something, we store it in white fat," said co-author Lily Dong, Ph.D., professor of cellular and structural biology at the UT Health Science Center. "For the extra food we eat, it is better to release it, not store it. So finding a way to turn the white fat into beige and burn the energy that normally we store would have high therapeutic potential for the treatment of obesity and its related diseases. Dr. Liu has identified the pathway to do this."

Broader application

The mTORC1 pathway is also involved in aging, cardiovascular disease and cancer, so identifying the regulator of this pathway, Grb10, should be very informative for researching other fields, Dr. Liu said.

Drs. Liu and Dong also are members of the Health Science Center's Barshop Institute for Longevity and Aging Studies.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Related medicine news :

1. Study finds coordinated approach improves quality of primary care
2. Survey finds significant gap in detection of malnutrition in Canadian hospital patients
3. Study finds risk of recurrence low in smallest HER2+ breast cancer tumors
4. Study finds that suicides are far more likely to occur after midnight
5. ALTTO test of dual HER2 blockade finds single agent remains the gold standard
6. Radiation for prostate cancer linked to secondary cancers, study finds
7. Study finds mode of transportation affects how we feel
8. Vanderbilt study finds women referred for bladder cancer less often than men
9. Personalizing revascularization strategy for STEMI patients is vital, EuroPCR panel finds
10. Screen of existing drugs finds compounds active against MERS coronavirus
11. Research finds few seizing patients receive EEGs in emergency department
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds on-off switch to burning stored fat
(Date:6/23/2017)... ... ... Studies show evidence that carotenoids and antioxidants derived either from the diet or from ... how often do ophthalmologists and optometrists in Sweden recommend the use of nutritional supplements, ... symptoms of AMD? A study published recently in Dove Medical Press journal, ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... in Newburgh, New York, has recently begun offering three new minimally invasive procedures ... best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited to bring microneedling, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference ... to read it, and some people don't like it at all. FindaTopDoc took a ... found: , Erotic literature can give readers a taste of their deepest, darkest fantasies ...
(Date:6/23/2017)... ... , ... The Aesthetic Channel has recently highlighted Dr. Ben Talei’s unique approach ... proprietary technique that he calls the AuraLyft Facelift. The AuraLyft does more ... can expect to look refreshed, rejuvenated, and revitalized. , Dr. Talei’s unique approach ...
(Date:6/23/2017)... ... June 23, 2017 , ... Georgia State University will host ... , The two-day conference is focused on advancing scientific knowledge about the aggressive ... and eliminating racial breast cancer-related disparities. The conference theme is “Illuminating Actionable Biology.” ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... 1, 2017 Nutriceutical Holdings (NH), parent company ... (VRS), and KD Pharma Group have decided to join ... KD Pharma Group. KD Pharma Group will become the ... acquire the entire company. "We believe we ... committed to growing the NH companies by providing us ...
(Date:5/30/2017)... AVIV, Israel , May 30, 2017 ... stage pharmaceutical Company specializing in the development of ... will present a company overview at three upcoming ... The 7th Annual LD Micro Invitational: ... Date:                     ...
(Date:5/26/2017)... , May 25, 2017  In response to ... , Direct Relief is working with Pfizer to ... available at no cost to community health centers, free ... providers nationwide. "Pfizer has a long-standing ... medicines and ensuring patient safety through educational activities," said ...
Breaking Medicine Technology: