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Team discovers new inhibitors of estrogen-dependent breast cancer cells
Date:6/16/2008

mplex, the team was able to screen a long list of potential therapeutic compounds to see if they inhibited the binding of the complex to the DNA. They then tested these agents in ER-positive breast cancer cells.

The team identified several compounds that reduce the binding of estrogen-receptor complex to the regulatory regions of genes that are normally activated by this complex. These agents effectively retarded production of the proteins that promote the growth and proliferation of ER-positive breast cancer cells.

"These small molecules specifically block growth of estrogen-dependent breast cancer cells with little or no effect on other cells," Shapiro said. "This work sets the stage for further development and testing of these inhibitors."


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Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert

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