Navigation Links
Team discovers how a cancer-causing bacterium spurs cell death
Date:11/1/2011

CHAMPAIGN, Ill. Researchers report they have figured out how the cancer-causing bacterium Helicobacter pylori attacks a cell's energy infrastructure, sparking a series of events in the cell that ultimately lead it to self-destruct.

H. pylori are the only bacteria known to survive in the human stomach. Infection with H. pylori is associated with an increased risk of gastric cancer, the second-leading cause of cancer-related deaths worldwide.

"More than half the world's population is currently infected with H. pylori," said University of Illinois microbiology professor Steven Blanke, who led the study. "And we've known for a long time that the host doesn't respond appropriately to clear the infection from the stomach, allowing the bacterium to persist as a risk factor for cancer."

The new study, in Proceedings of the National Academy of Sciences, is the first to show how a bacterial toxin can disrupt a cell's mitochondria its energy-generation and distribution system to disable the cell and spur apoptosis (programmed cell death).

"One of the hallmarks of long-term infection with H. pylori is an increase in apoptotic cells," Blanke said. "This may contribute to the development of cancer in several ways." Apoptosis can damage the epithelial cells that line the stomach, he said, "and chronic damage to any tissue is a risk factor for cancer." An increase in apoptotic cells may also spur the hyper-proliferation of stem cells in an attempt to repair the damaged tissue, increasing the chance of mutations that can lead to cancer.

Previous studies had shown that VacA, a protein toxin produced by H. pylori, induces host cell death, Blanke said, "but the mechanism had been
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. 23andMe discovers genetic variant that may protect those at risk for Parkinsons disease
2. Louisiana State University Health Sciences Center research discovers key to survival of brain cells
3. UNH researcher discovers research manipulated to support pro-eugenic beliefs
4. Research discovers genetic link to Barretts esophagus, esophageal cancer
5. Expert discovers simple method of dealing with harmful radioactive iodine
6. UCSF team discovers key to fighting drug-resistant leukemia
7. UCSF team discovers new way to predict breast cancer survival and enhance effectiveness of treatment
8. OHSU Doernbecher discovers new approach to drug resistance in aggressive childhood cancer
9. MU chemist discovers shortcut for processing drugs
10. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
11. UT professor defines play, discovers even turtles need recess
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team discovers how a cancer-causing bacterium spurs cell death
(Date:8/23/2014)... CA (PRWEB) August 23, 2014 ... trading system created by Greg Marks has been generating ... earlier this month. The commotion surrounding the new product ... an investigative review. , “In recent years ... trading software systems, commonly referred to as robots or ...
(Date:8/23/2014)... August 23, 2014 GBI Research, the ... “Critical Care Therapeutics in Major Developed Markets to 2020 ... to Drive Market”, which provides in-depth analysis of the ... Italy, Spain, Japan and Canada. The report provides an ... forecasts to 2020. It covers critical care indications that ...
(Date:8/23/2014)... August 23, 2014 Professional kitchen employees, ... study aid in preparing for Food Safety Certification exams ... by Dynamic Path. , Dynamic Path announced the ... includes more than 200 review questions for culinary industry ... designed to cover requirements of the ServSafe® Food Safety ...
(Date:8/23/2014)... Young adults in Athens, GA who find that they have a ... and call the new helpline which can offer support and guidance ... Teen Athens is a wonderful resource for an adolescent drug or ... to end substance abuse once and for all. When a young ... peers when really they should put their faith in a youth ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 Youth substance ... Texas. It’s no different in Houston, TX. Substance abuse ... falling victim to drug and alcohol dependency in higher ... looking to beat substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
Breaking Medicine News(10 mins):Health News:Legal Insider Bot Review Examining Greg Marks’ Trading Software Released 2Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 2Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 3Health News:Food Handler Safety Certification Made Easy with Dynamic Path 2Health News:Teenagers in Athens, GA are Locating Addiction Recovery Thanks to New Helpline 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2
... affecting Calcutta has arrived in Delhi and three deaths have ... weeks. //, ,In 2003 there were more than 30 ... reported. , ,N.K. Yadav, deputy health officer, Municipal Corporation ... control. They have hired 1,055 more health workers to check ...
... Cancer Institute had discovered a new molecular explanation for ... the disease called porphyria, the disease that was probably ... ,The Dana-Farber scientists say in a report featured ... the journal Cell that the nutritional component of porphyria ...
... a as paranormal phenomena, may in fact have their roots ... the high incidence of OBE among the general public, not ... of the population have an out-of-body experience (OBE) at some ... physical body from the outside. It isn't uncommon for people ...
... Indian Biotech Company, Biocon to colloborate with Nobex ... oral peptide drug for cardiovascular diseases. The spokesperson ... into global research collaboration // on Tuesday for ... cardiovasculoar diseases. The Biocon press release said, “The ...
... in the September issue of the Harvard Health Letter, ... quick and short working out sessions may not help ... can lead to diseases. To prevent weight gain and ... sessions are required every week. ,Furthermore, some ...
... infection of newborns with herpes type 1 and 2 ... is not an established procedure in most cases., ... the // journal Sexually Transmitted Diseases, researchers in herpes ... STD in Seattle, point out that unlike all comparable ...
Cached Medicine News:Health News:Study Unveils New Insight To The Madness Of King George III 2Health News:Experts Insist That Neonatal Herpes Be Reported Regularly 2
(Date:8/21/2014)... , Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... gynecologic cancers and women,s health, has appointed Holly ... Managed Markets. Ms. Bauzon has a proven ... payer coverage for laboratory services companies. She has more ... PerkinElmer, Inc., where she held the position of Director, ...
(Date:8/21/2014)... 2014 /CNW/ - Eisai Limited is pleased to support the ... comic book available in Canada . The ... to educate children and their parents about epilepsy, the most ... more than 300,000 Canadians. Eisai is guided by a corporate ... which the patient is central – there was a need ...
(Date:8/21/2014)... 21, 2014 /PRNewswire-iReach/ -- ScriptPro has been certified ... its Common Security Framework (CSF). According to ... Manager, "We appreciate this rigorous, top-to-bottom audit. Security-minded ... this certification signifies. Our business partners need to ... CSF CERTIFICATION PROCESS: ScriptPro,s internal security processes and ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2ScriptPro Achieves HITRUST Certification 2
... Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ), ... human disease, announced today that Arthur T. Sands, ... will present at the Stifel Nicolaus Healthcare Conference in ... Eastern Time.  Dr. Sands will provide an overview on ...
... 2011 Reportlinker.com announces that a new market ... Pharmaceutical Distributors - Global ... This register contains information about 2800 ... register includes the following information about the ...
Cached Medicine Technology:Lexicon Pharmaceuticals to Present at Stifel Nicolaus Healthcare Conference 2
For the quantitative in vitro determination of Inorganic Phosphorous in serum....
For the quantitative in vitro determination of total and direct bilirubin in serum or plasma....
For the quantitative in vitro determination of Anti-Streptolysin-O (ASO) in serum....
For the quantitative in vitro determination of total protein in urine and c.s.f....
Medicine Products: