Navigation Links
Taxol bristle ball: a wrench in the works for cancer
Date:9/12/2007

HOUSTON, Sept. 12, 2007 Rice University chemists have discovered a way to load dozens of molecules of the anti-cancer drug paclitaxel onto tiny gold spheres. The result is a tiny ball, many times smaller than a living cell that literally bristles with the drug.

Paclitaxel, which is sold under the brand name Taxol, prevents cancer cells from dividing by jamming their inner works.

"Paclitaxel is one of the most effective anti-cancer drugs, and many researchers are exploring how to deliver much more of the drug directly to cancer cells," said lead researcher Eugene Zubarev, the Norman Hackerman-Welch Young Investigator and assistant professor of chemistry at Rice. "We looked for an approach that would clear the major hurdles people have encountered -- solubility, drug efficacy, bioavailability and uniform dispersion -- and our initial results look very promising."

The research is available online and will appear in the Sept. 19 issue of the Journal of the American Chemical Society (J. Am. Chem. Soc. 2007, vol. 129, pgs.11653-11661).

First isolated from the bark of the yew tree in 1967, paclitaxel is one of the most widely prescribed chemotherapy drugs in use today. The drug is used to treat breast, ovarian and other cancers.

Paclitaxel works by attaching itself to structural supports called microtubules, which form the framework inside living cells. In order to divide, cells must break down their internal framework, and paclitaxel stops this process by locking the support into place.

Since cancer cells divide more rapidly than healthy cells, paclitaxel is very effective at slowing the growth of tumors in some patients. However, one problem with using paclitaxel as a general inhibitor of cell division is that it works on all cells, including healthy cells that tend to divide rapidly. This is why patients undergoing chemotherapy sometimes suffer side effects like hair loss and suppressed immune function.


'/>"/>
Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fireworks can spell death for asthmatic children
2. How a mans mind really works
3. Drug Combo Works Better for children with ADHD, Tics
4. How brain works
5. Meditation Works Medically
6. A first in Liver Transplant in India – Networking works wel
7. Warts: Spanner in Lovers Works!
8. Shot Supply: Reduced Dosage of Seasonal flu Vaccine, Works!
9. Subliminal Advertising works
10. De-addiction Drug Works For Alcoholics Too
11. Vagal Nerve Stimulation Works To Treat Severe Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... LiveOps, Inc., the global leader in cloud ... LiveOps has been selected as a call center provider ... Telethon for the third year in a row. This ... support MDA’s mission to help children and adults affected ... disease. This year’s program includes performances by Bret Michaels, ...
(Date:8/29/2014)... Thirteen Novant Health registered nurses have ... in North Carolina list by Great 100, Inc., ... to nursing students at all levels across the state. ... Medical Center are: Rea Buie, Carol Caldwell, Susan ... Amber Segerlin, Carmen Smith, Melissa Stafford and Deborah Stegall. ...
(Date:8/29/2014)... Steven Reinberg HealthDay ... -- The vast majority of American babies are getting ... illnesses, federal health officials said Thursday. More than ... prevent measles, mumps, and rubella (MMR); polio; hepatitis B ... Disease Control and Prevention. "Nationally, vaccination among children ...
(Date:8/29/2014)... EDMONTON, AB A new study from the research group ... AB) and the Lawson Health Research Institute (London, ON) has ... of cancer. The study, published in Cell Reports , ... spread of cancer entirely. , Roughly 2 in 5 ... four of them will die of the disease. In 2014, ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... be slippery, especially when wearing socks. Also, many patients ... ambulatory problems, poor balance, surgery recovery, Alzheimer’s, etc. Two ... in order to optimize patient safety. , This special ... medical-facility floors. It also keeps patients who are relegated ...
Breaking Medicine News(10 mins):Health News:LiveOps Supports Muscular Dystrophy Association Show of Strength Telethon 2Health News:LiveOps Supports Muscular Dystrophy Association Show of Strength Telethon 3Health News:LiveOps Supports Muscular Dystrophy Association Show of Strength Telethon 4Health News:Great 100 Honors 13 Novant Health Nurses 2Health News:Most U.S. Babies Get Their Vaccines: CDC 2Health News:Most U.S. Babies Get Their Vaccines: CDC 3Health News:Preventing cancer from forming 'tentacles' stops dangerous spread 2
... , , , , ... and all MinuteClinic medical clinics throughout Arizona are now offering H1N1 ... MinuteClinic locations in Illinois in the Chicago area and in Nevada ... with no appointment necessary. Priority group restrictions have been lifted in ...
... ... tooth whitening procedures. , ... CA (PRWEB) Dec. 21, 2009 -- If you are thinking about giving the gift of ... have all the facts to become a smart shopper of this popular cosmetic process. , ...
... rats when resin was part of diet, study finds , ... in the Middle East -- known as myrrh -- may ... author explained that myrrh resin could be used in conjunction ... not clear yet how people might consume it, and more ...
... , CANTON, Mass., Dec. 21 Organogenesis, Inc. ... (PMA) with the U.S. Food and Drug Administration (FDA) for ... regeneration. If approved, CelTx will be the first, living ... market. , A pioneer in the field, Organogenesis ...
... , CHESTERFIELD, Mo., Dec. 21 ... scientific officer of Reliv International, Inc., was elected to the ... the nation,s leading trade association for the dietary supplement industry. ... control and manufacturing for Reliv, a direct selling company of ...
... , , SANTA CLARA, Calif., Dec. ... in enterprise mobility, today announced that it swept top honors ... MobileVillage® Mobile Star Awards(TM) program, as a result of industry ... and news services about mobile technology. , As in past ...
Cached Medicine News:Health News:CVS/pharmacy and MinuteClinic Now Providing H1N1 Vaccinations in Arizona 2Health News:CVS/pharmacy and MinuteClinic Now Providing H1N1 Vaccinations in Arizona 3Health News:Dreaming of a Whiter Christmas and New Year for Your Teeth? 2Health News:Organogenesis Files PMA for CelTx(TM) for Oral Soft Tissue Regeneration 2Health News:Organogenesis Files PMA for CelTx(TM) for Oral Soft Tissue Regeneration 3Health News:Reliv International's Carl W. Hastings Elected to Board of the Council for Responsible Nutrition 2Health News:Industry Names Agito Networks, Company CTO, FMC Customer to Top MobileVillage Honors for 2009 2Health News:Industry Names Agito Networks, Company CTO, FMC Customer to Top MobileVillage Honors for 2009 3Health News:Industry Names Agito Networks, Company CTO, FMC Customer to Top MobileVillage Honors for 2009 4
(Date:8/29/2014)... DUBLIN , Aug. 29, 2014 ... the "China Orthopedic Instrument Industry Report, 2014-2017" ... accelerated aging population and rising proportion of reimbursement for ... been effectively released, with its scale presenting a CAGR ... joint products are three product segments of orthopedic instruments ...
(Date:8/29/2014)... Research and Markets  has announced the addition of the ... their offering. The Central Nervous System (CNS) ... of pharmaceuticals industry. The numbers of CNS disorders have increased ... to meet the market requirements. There has been steady to ... the past two decades. The market for CNS therapies is ...
(Date:8/29/2014)... DENVER , Aug. 29, 2014 Does your ... date, nearly 800 doctors have recommended marijuana to the over ... Amendment 20. But the majority of the other roughly 20,300+ ... still know very little about it – even though a ... adults say they have tried it. ...
Breaking Medicine Technology:China Orthopedic Instrument Industry Report, 2014-2017 2US CNS Disorders Drug Pipeline Insight 2014 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4
... 2012 OPKO Health, Inc. and ChromaDex Corporation (OTCBB: ... alliance pursuant to which ChromaDex has licensed to OPKO ... technologies for distribution and business development throughout all of ... BluScience™ ( www.bluscience.com ), ChromaDex,s recently launched ...
... 2012 Uroplasty, Inc. (NASDAQ: UPI ), ... innovative proprietary products to treat voiding dysfunctions, today announced ... study in the United Kingdom. This large ... up to 20 centers across the UK. Using Uroplasty,s ...
Cached Medicine Technology:OPKO Health, Inc. Invests in ChromaDex® Corp. 2OPKO Health, Inc. Invests in ChromaDex® Corp. 3OPKO Health, Inc. Invests in ChromaDex® Corp. 4OPKO Health, Inc. Invests in ChromaDex® Corp. 5Uroplasty Announces Enrollment of First Patients in the CONFIDeNT Clinical Study for Treatment of Fecal Incontinence with Urgent® PC 2Uroplasty Announces Enrollment of First Patients in the CONFIDeNT Clinical Study for Treatment of Fecal Incontinence with Urgent® PC 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: