Navigation Links
Taurine: Key to the visual toxicity of an anti-epileptic drug for children?
Date:2/17/2009

Vigabatrin (Sabril), first intention molecule for the treatment of epilepsy in children, in many cases produces secondary effects that lead to an irreversible loss of vision. Serge Picaud, head of research at Inserm, and his colleagues of the Institut de la Vision have just discovered the origin of this secondary effect and have proposed strategies for limiting it. They have shown that vigabatrin provokes a marked decrease in the blood level in an amino acid, taurine, resulting in a degeneration of the retina cells induced by light. The researchers therefore suggest that exposure to light should be reduced and a taurine-rich diet introduced in order to curb immediately these secondary effects in children undergoing treatment. As for the validation of an alternative treatment associating vigabatrin and taurine, this will necessitate several years of development.

This work is published in the review Annals of Neurology.

Epilepsy affects 1% of the world's population. With children, its treatment remains extremely restricted, and vigabatrin, (marketed in France under the name of Sabril), has obtained marketing authorisation for children aged under 2 years. This anticonvulsant, which is also administered to adults in the case of failure of other treatments, is at the same time now being evaluated for the treatment of addiction to heroin, cocaine and methamphetamines.

However, the serious secondary effects of this drug can induce an impairment of the retina and a restriction of the visual field, noted, depending on the studies, in 10% to 40% of patients.

In order to reach an understanding of this drug's modes of actions, and in particular the mechanism of visual function impairment, the Inserm researchers first of all administered vigabatrin to rats over a period of several months and analysed the influence of exposure to light during the treatment. The results show that there is no damage to the retina when the animals are kept in the dark throughout the treatment.

Moreover, since previous work had shown that a deficiency of the organism in taurine (amino acid) triggers the degeneration of the photoreceptors (cells of the retina converting light into nervous signals), the researchers measured, in rodents, the plasma level of 19 amino acids. Whereas the concentration was identical for most of the amino acids in animals under vigabatrin and in non-treated rats, the taurine level turned out to be 67% lower in treated animals

Taurine is essentially contributed by diet. By providing certain of the animals under treatment with a taurine supplementation, the researchers noted that their visual acuity was greater than that of the animals without supplementation. In addition, the amino acid doses administered to six children subject to regular attacks of epilepsy and treated under vigabatrin reveal a taurine level that is far below the normal values reported for children of the same age and in some cases even undetectable.

On the strength of these various tests, the scientists were able to prove that vigabatrin induces a pronounced reduction of the taurine level in the plasma. This marked fall is responsible for the degeneration of the photoreceptors and thus for the retinal toxicity in the animals exposed to light.

Pending confirmation in the human of the interest of providing patients under vigabatrin with a taurine supplementation, the researchers propose immediate solutions designed to limit the secondary effects in these patients. "In the first instance, care should therefore be taken to ensure that patients under vigabatrin consume a sufficient amount of food containing taurine. It is also important that they should be exposed to as little light as possible (e.g.; no night lights in a baby's bedroom at night) and should be induced to wear sunglasses", says Serge Picaud.

The researchers also emphasise that any taurine supplementation must be subject to medical advice.


'/>"/>

Contact: Priscille Riviere
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related medicine news :

1. Moshi Names Independent Living Aids Exclusive Distributor in Blindness and Visual Impairment Field
2. Simple brain mechanisms explain arbitrary human visual decisions
3. Retina Group of New York To Present Seminar on Age-Related Macular Degeneration; The Leading Cause of Visual Loss in Seniors
4. Study suggests human visual system could make powerful computer
5. Hybrid Cars Pose Risk to Blind, Visually Impaired
6. Sign Language Associates and Visual Language Interpreting Combine With GoAmerica to Form Nations Premier Sign Language Interpreting Services Company
7. Photos: For the First Time Researchers Show Reversal of an Aging Marker in the Human Retina Correlated with Visual Improvement Using a Nutraceutical Matrix (Longevinex(R))
8. Edge Health Solutions Releases edgeDMS(TM) 2.0 and edgeMD 2.0(TM), Revolutionary All-in-One Practice Management Software with FDA-Approved Advanced Visualization
9. Michael J. Fox Foundation for Parkinsons Research Commits up to $2 million to Visualize Alpha-Synuclein Protein in the Brain
10. Sleep-Deprived Brains Show Lapse in Visual Processing
11. New Web Community Brings Together Parents of Visually Impaired Children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
Breaking Medicine Technology: