Navigation Links
Taurine: Key to the visual toxicity of an anti-epileptic drug for children?

Vigabatrin (Sabril), first intention molecule for the treatment of epilepsy in children, in many cases produces secondary effects that lead to an irreversible loss of vision. Serge Picaud, head of research at Inserm, and his colleagues of the Institut de la Vision have just discovered the origin of this secondary effect and have proposed strategies for limiting it. They have shown that vigabatrin provokes a marked decrease in the blood level in an amino acid, taurine, resulting in a degeneration of the retina cells induced by light. The researchers therefore suggest that exposure to light should be reduced and a taurine-rich diet introduced in order to curb immediately these secondary effects in children undergoing treatment. As for the validation of an alternative treatment associating vigabatrin and taurine, this will necessitate several years of development.

This work is published in the review Annals of Neurology.

Epilepsy affects 1% of the world's population. With children, its treatment remains extremely restricted, and vigabatrin, (marketed in France under the name of Sabril), has obtained marketing authorisation for children aged under 2 years. This anticonvulsant, which is also administered to adults in the case of failure of other treatments, is at the same time now being evaluated for the treatment of addiction to heroin, cocaine and methamphetamines.

However, the serious secondary effects of this drug can induce an impairment of the retina and a restriction of the visual field, noted, depending on the studies, in 10% to 40% of patients.

In order to reach an understanding of this drug's modes of actions, and in particular the mechanism of visual function impairment, the Inserm researchers first of all administered vigabatrin to rats over a period of several months and analysed the influence of exposure to light during the treatment. The results show that there is no damage to the retina when the animals are kept in the dark throughout the treatment.

Moreover, since previous work had shown that a deficiency of the organism in taurine (amino acid) triggers the degeneration of the photoreceptors (cells of the retina converting light into nervous signals), the researchers measured, in rodents, the plasma level of 19 amino acids. Whereas the concentration was identical for most of the amino acids in animals under vigabatrin and in non-treated rats, the taurine level turned out to be 67% lower in treated animals

Taurine is essentially contributed by diet. By providing certain of the animals under treatment with a taurine supplementation, the researchers noted that their visual acuity was greater than that of the animals without supplementation. In addition, the amino acid doses administered to six children subject to regular attacks of epilepsy and treated under vigabatrin reveal a taurine level that is far below the normal values reported for children of the same age and in some cases even undetectable.

On the strength of these various tests, the scientists were able to prove that vigabatrin induces a pronounced reduction of the taurine level in the plasma. This marked fall is responsible for the degeneration of the photoreceptors and thus for the retinal toxicity in the animals exposed to light.

Pending confirmation in the human of the interest of providing patients under vigabatrin with a taurine supplementation, the researchers propose immediate solutions designed to limit the secondary effects in these patients. "In the first instance, care should therefore be taken to ensure that patients under vigabatrin consume a sufficient amount of food containing taurine. It is also important that they should be exposed to as little light as possible (e.g.; no night lights in a baby's bedroom at night) and should be induced to wear sunglasses", says Serge Picaud.

The researchers also emphasise that any taurine supplementation must be subject to medical advice.


Contact: Priscille Riviere
INSERM (Institut national de la sant et de la recherche mdicale)

Related medicine news :

1. Moshi Names Independent Living Aids Exclusive Distributor in Blindness and Visual Impairment Field
2. Simple brain mechanisms explain arbitrary human visual decisions
3. Retina Group of New York To Present Seminar on Age-Related Macular Degeneration; The Leading Cause of Visual Loss in Seniors
4. Study suggests human visual system could make powerful computer
5. Hybrid Cars Pose Risk to Blind, Visually Impaired
6. Sign Language Associates and Visual Language Interpreting Combine With GoAmerica to Form Nations Premier Sign Language Interpreting Services Company
7. Photos: For the First Time Researchers Show Reversal of an Aging Marker in the Human Retina Correlated with Visual Improvement Using a Nutraceutical Matrix (Longevinex(R))
8. Edge Health Solutions Releases edgeDMS(TM) 2.0 and edgeMD 2.0(TM), Revolutionary All-in-One Practice Management Software with FDA-Approved Advanced Visualization
9. Michael J. Fox Foundation for Parkinsons Research Commits up to $2 million to Visualize Alpha-Synuclein Protein in the Brain
10. Sleep-Deprived Brains Show Lapse in Visual Processing
11. New Web Community Brings Together Parents of Visually Impaired Children
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... The Lymphoma Research Foundation ... research and serving the lymphoma community through a comprehensive series of education programs, ... Hope; A Commitment to Cure last night at the Mandarin Oriental in New ...
(Date:10/13/2015)... — , ... ... Association of America (MOAA) will hold its 2015 annual meeting ... a free military career fair; informational seminars; a luncheon featuring ... the Joint Chiefs of Staff; and the Community Heroes Award ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... Vision Group ... Vision of San Diego, California. With brands including The LASIK Vision Institute and TLC ... making it the nationwide leader in laser vision correction. , Global Laser Vision will ...
(Date:10/13/2015)... ... October 13, 2015 , ... PhyMed Healthcare Group , ... its partnership with WPC Healthcare , a provider of predictive analytics solutions ... data into an aggregated data repository necessary to perform reporting and analytics on ...
(Date:10/13/2015)... Texas (PRWEB) , ... October 13, 2015 , ... Symposium ... for the 19th annual Dallas Cosmetic Symposium to be held March 2nd and 3rd, ... place immediately afterwards, draws plastic surgeons and cosmetic physicians from around the world. , ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... YORK , Oct. 13, 2015 Pomerantz ... filed against Amicus Therapeutics, Inc. ("Amicus" or the "Company")(NASDAQ: ... filed in United States District Court, District of ... a class consisting of all persons or entities who ... 1, 2015 inclusive (the "Class Period"). This class action seeks ...
(Date:10/13/2015)... , Oct. 13, 2015  Vitamin Angels – ... and mothers in need of nutritional support - announced ... by the United Nations (UN). The UN,s newly established ... – are a recent follow up to the Millennium ... deadline for completion. The new 17 Global Goals intend ...
(Date:10/13/2015)... , Oct. 13, 2015   Generational Equity ... middle-market businesses, is pleased to announce the acquisition of ... in Largo, Florida , by Meridian ... on September 11, 2015. Florida ... --> Florida . To learn ...
Breaking Medicine Technology: