Navigation Links
Tau protein expression predicts breast cancer survival -- though not as expected
Date:12/13/2008

SAN ANTONIO - Expression of the microtubule-binding protein Tau is not a reliable means of selecting breast cancer patients for adjuvant paclitaxel chemotherapy, according to research led by The University of Texas M. D. Anderson Cancer Center.

Presented today, Dec. 13, at the CRTC-AACR San Antonio Breast Cancer Symposium, the researchers found that Tau expression does predict survival, yet in an unexpected way.

In earlier neoadjuvant studies, investigators from M. D. Anderson found that low levels of Tau predicted a good response to pre-operative chemotherapy. In vitro studies had shown that down-regulation of Tau expression increased the sensitivity of breast cancer cell lines to paclitaxel. Other studies suggested that high levels of Tau partially protect microtubules from paclitaxel binding and that low levels of the protein leave microtubules more accessible and vulnerable to the drug.

"If you treat patients who have a low level of Tau protein expression with pre-operative chemotherapy in neo-adjuvant studies, they are very likely to have a good response to the chemotherapy," said Lajos Pusztai, M.D., D. Phil, associate professor of medicine in the Department of Breast Medical Oncology at M. D. Anderson and the study's first author. "We wanted to see if this correlation would hold up in predicting survival in adjuvant studies."

Working with researchers from the National Surgical Adjuvant Breast and Bowel Project (NSABP), the investigators assessed Tau protein expression in primary breast cancer specimens from 1,942 patients in the NSABP-B28 clinical trial. The goal was to evaluate the prognostic value of Tau in these patients, who were treated with four courses of doxorubicin/cyclophosphamide (AC) or AC followed by four courses of paclitaxel. All hormone receptor-positive patients in the trial also received adjuvant endocrine therapy.

The hypothesis was that patients whose tumors expressed low levels of Ta
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tau protein expression predicts breast cancer survival -- though not as expected
Tau protein expression predicts breast cancer survival -- though not as expected
(Date:12/4/2009)NEW YORK, Dec. 4 Thousands of KPMG LLP employees came together in more than 90 offices nationwide today, to participate in a community service event which combines the audit, tax and advisory firm,s
(Date:12/4/2009)PEMBROKE, Bermuda, Dec. 4 Allied World Assurance,Company Holdings, Ltd (NYSE: AWH ) today announced that Scott Carmilani,President and Chief Executive Officer, and Jack Sennott, Executive Vice,Pres
(Date:12/4/2009)SCOTTSDALE, Ariz., Dec. 4 Healthcare Trust of America, Inc. ("HTA"), a self-managed, non-traded, real estate investment trust, announced the execution of a purchase and sale agreement to acquire a th
(Date:12/4/2009)MADISON HEIGHTS, Mich., Dec. 4 The Editorial Advisory and Securities Review Committee of BetterInvesting Magazine today announced Allergan, Inc. (NYSE: AGN ) as its February 2010 "Stock to Stud
(Date:12/4/2009)WASHINGTON, Dec. 4 While Congress debates whether health care reform would control health care costs, Leapfrog,s purchaser members point to 45 hospitals that lead through example -- delivering the be
Breaking Medicine News(10 mins):Health News:KPMG Employees Provide 'Holiday Bear Hugs' and Books in Firmwide Service Day for Children 2Health News:Allied World to Present at the 2009 Goldman Sachs U.S. Financial Services Conference 2Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire a 92,500 Square Foot Medical Office Portfolio Located in Texas and Indiana 2Health News:BetterInvesting Magazine Releases February Stock to Study and Undervalued Stock Choicesfor Investors' Informational and Educational Use 2Health News:The Leapfrog Group Releases Its 2009 Top Hospitals List 2Health News:The Leapfrog Group Releases Its 2009 Top Hospitals List 3
...vider of SOA based data profiling, In-Stream profi...ounces today that it has become a partner in the M...ft Corp. and other key industry partners working t... Chicago, IL (PRWEB) December 16, 2008 -- AMB, a ...
...e Full Support for Clinical Activities , , RO...NMD ), a clinical-stage pharmaceutical company ann...s on its most promising near-term product candidat...calls for acceleration of the Company,s 2009 clini...
...alads over French fries? According to a new study ...choose from a large variety of menu items are more...oose from shorter lists. , In a study that looked...y Liu (UCLA) examined the way consumers justify th...
...chers from Yale University School of Medicine comp...ication to standard white light colonoscopy in dif...lonoscopy and found that NBI was not more accurate... tool. Once this learning curve was achieved, NBI ...
...sparency , , PITTSBURGH, Dec. 15 Highmark B...h online physician quality information in an effor...sions. , , "Today, more people have greater ...d quality performance management. "Publicly report...
...n killer disease, scientists say , , MONDA...y a particular gene may provide a new target for t... , Experiments at the Mayo Clinic College of Medi...eviously linked to excessive growth of pancreatic ...
Other Medicine News:Health News:AMB New Generation Data Empowerment Joins Mainframe Migration Alliance 2Health News:AMB New Generation Data Empowerment Joins Mainframe Migration Alliance 3Health News:EntreMed Focuses on Development of ENMD-2076 2Health News:EntreMed Focuses on Development of ENMD-2076 3Health News:EntreMed Focuses on Development of ENMD-2076 4Health News:EntreMed Focuses on Development of ENMD-2076 5Health News:The virtue of variety: More options can lead to healthier choices 2Health News:Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps 2Health News:Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps 3Health News:Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps 4Health News:Highmark Blue Cross Blue Shield Provides Online Physician Quality Information to Members 2Health News:Pancreatic Cancer May Have a New Foe 2
(Date:12/4/2009)BILLERICA, Mass., Dec. 4 Axsun Technologies, Inc., a wholly-owned subsidiary of Volcano Corporation (Nasdaq: VOLC ), today announced the initial development and successful testing of a novel integra
(Date:12/4/2009)TARRYTOWN, N.Y., Dec. 4 Bayer Diabetes Care today announced the three grand prize winners of Bayer,s "Express Your Simple Win Creativity Contest." Nick Jonas, of the Jonas Brothers, selected the winn
(Date:12/4/2009)WILMINGTON, Del., Dec. 4 AstraZeneca (NYSE: AZN ) today announced that the US Food and Drug Administration (FDA) has approved once-daily SEROQUEL XR® (quetiapine fumarate) Extended Release Tab
Breaking Medicine Technology:Axsun Technologies, A Wholly-Owned Subsidiary of Volcano Corporation, Announces Breakthrough Integrated Light Source Architecture for Optical Coherence Tomography (OCT) Imaging 2Axsun Technologies, A Wholly-Owned Subsidiary of Volcano Corporation, Announces Breakthrough Integrated Light Source Architecture for Optical Coherence Tomography (OCT) Imaging 3Axsun Technologies, A Wholly-Owned Subsidiary of Volcano Corporation, Announces Breakthrough Integrated Light Source Architecture for Optical Coherence Tomography (OCT) Imaging 4Axsun Technologies, A Wholly-Owned Subsidiary of Volcano Corporation, Announces Breakthrough Integrated Light Source Architecture for Optical Coherence Tomography (OCT) Imaging 5Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 2Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 3US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 2US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 3US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 4US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 5US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 6US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 7US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 8US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 9Medizone International Inc Has Filed for Patent Protection for Its AsepticSure 28TM 29 Hospital Sterilization System 51452 1Medizone International Inc Has Filed for Patent Protection for Its AsepticSure 28TM 29 Hospital Sterilization System 51452 2Instrumentation Laboratory to Announce Passion 26 Results Award Winners 12987 1Instrumentation Laboratory to Announce Passion 26 Results Award Winners 12987 2Instrumentation Laboratory to Announce Passion 26 Results Award Winners 12987 3Bathtub Accidents Injure 43 000 U S Kids Each Year 51446 1Bathtub Accidents Injure 43 000 U S Kids Each Year 51446 2
...iread(R) versus Clevudine+Viread(R) in 150 pa... July 8 The French National,Agency for Research o...t of,Pharmasset, Inc. (Nasdaq: VRUS ) and Gilead ...first head-to-head study of clevudine and Viread(R...arately, versus their,combination, for the treatme...
...98 and ANA773 Acting via Independent but ... Conference Call Today at 2:00 PM PDT, SAN DIE...ANDS ) announced today that it is resuming clinica... mechanism for the,treatment of chronic hepatitis ...he results of completed 13-week GLP animal toxicol...
Other Medicine Technology:Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS) 2Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS) 3Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS) 4Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV 2Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV 3Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV 4Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV 5
Fibrinogen Control
MONO Mononucleosis Rapid Test Device
...Z Flu A+B test is a rapid chromatographic immunoas...fluenza A and B viral antigens from nasopharyngeal...patients. The Directigen EZ Flu A+B test is a diff...ens can be distinguished from influenza B viral an...
..., the Jarvik 2000 pump is about the size of a C ba...ect-current motor, a rotor supported by two cerami...nning titanium impeller that pumps blood from the ...ke over for the biological heart, the Jarvik 2000 ...
Medicine Products: