Navigation Links
Tattooing Best Way to Deliver DNA Vaccines
Date:2/7/2008

Showed stronger antibody, cellular responses than intramuscular injection, study says

THURSDAY, Feb. 7 (HealthDay News) -- Tattooing is a more effective method for delivering DNA vaccines than intramuscular injection, a new German study finds.

Publishing in the online journal Genetic Vaccines and Therapy, researchers at the German Cancer Research Center in Heidelberg used a coat protein from the human papillomavirus (HPV), which causes cervical cancer, as a model DNA vaccine antigen. DNA vaccines are created using a modified form of an infectious organism's DNA.

In tests on mice, the researchers compared tattooing and intramuscular injection, with and without the adjuvants that are often given to boost immune response.

The tattoo method produced stronger antibody and cellular response than intramuscular injection, even when adjuvants were included in the injections. Three doses of DNA vaccine given by tattoo produced at least 16 times higher antibody levels than three intramuscular injections with adjuvant, the study found.

While adjuvants boosted the effect of intramuscular injection, it did not enhance the effect of tattooing.

The researchers explained that tattooing, which is done with a solid vibrating needle, causes a wound and sufficient inflammation to "prime" the immune system. It also covers a larger area of the skin than an injection, which means the DNA vaccine can enter more cells. This may be why tattooing produces a stronger immune response.

Because tattooing is painful, it may not be suitable for everyone. But it could prove useful in a number of areas, including cattle vaccination or therapeutic (rather than preventive) vaccination of humans, the researchers said.

"Vaccination with naked DNA has been hampered by its low efficiency. Delivery of DNA via tattooing could be a way for a more widespread commercial application of DNA vaccines," researcher Martin Muller said in a prepared statement.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about vaccines.



-- Robert Preidt



SOURCE: BioMed Central, news release, Feb. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Satellite data to deliver state-of-the-art air quality information
2. Scooter Store Executives to Deliver Power Wheelchair Donation to New Braunfels Car Crash Victim
3. Top-Rated Hospitals Continue to Deliver Better Care
4. Dannemiller Memorial Education Foundation and GR MedEd, Inc. Announce Oncology Summit: From Discovery to Delivery
5. Answering Bush SOTU Retirement Reform Challenge, Long Term Care Profession Urges Congress to Enact Bold Reform of Long Term and Post Acute Care Delivery Systems
6. Liquent Insight Publisher 3.6 Delivers Advanced Submission Capabilities
7. Activists Raise Alarm for Seniors, Deliver Carbon Monoxide Detectors to Atria Marland Place
8. Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross and Lifetime Television Deliver 20 Million Online Petition Signatures to Capitol Hill to Urge Congress to Stop Drive-Through Mastectomies
9. Scientists use nanomaterials to localize and control drug delivery
10. Struggling Medical Delivery System Impacts Hospitals and Physicians Hardest
11. March of Dimes Delivers a New Look
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tattooing Best Way to Deliver DNA Vaccines
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
Breaking Medicine Technology: