Navigation Links
Targeting the protein AEG1 impairs human liver cancer growth in mice
Date:2/16/2009

Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer and one of the 5 most common cancers worldwide. Devanand Sarkar and colleagues, at Virginia Commonwealth University School of Medicine, Richmond, have now identified a gene that is expressed at high levels in human HCC tumor samples and generates a protein important for HCC progression. They therefore suggest that targeting this gene (AEG1), or the protein that it generates, might provide a new therapeutic strategy for the treatment of HCC.

In the study, human liver cells were found to express only low levels of the protein AEG1, whereas human HCC tumor samples expressed very high levels. This was associated with an increase in the number of copies of the AEG1 gene in human HCC tumor samples. Functionally, human liver cell lines engineered to overexpress AEG1 grew faster than nonengineered cells and developed into highly aggressive tumors when transplanted into mice. In addition, knocking down levels of AEG1 in human HCC cell lines after they had been allowed to form a tumor in mice limited further growth. Further analysis revealed that the effects of AEG1 were mediated, in part, via its ability to activate the Wnt signaling pathway.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Tobacco Companies Targeting Teens, Study Says
2. APIC 2009 Targeting Zero Initiative Offers Practical Tools, Evidence-Based Elimination Strategies to Prevent the Deadliest Healthcare-Associated Infections
3. Targeting Cancers Own Stem Cells to Fight Recurrence
4. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
5. Health Care Service Corporation Finds Success With Innovative Program Targeting Obesity Epidemic
6. Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Anti-Viral Applications of Phospholipid-Targeting Antibodies
7. EGFR-targeting antibody licensed to Abbott
8. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
9. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
10. NO on Prop 8 Campaign Slams Dishonest Mailer Targeting African-American Voters
11. Norwegian American Hospital Launches Awareness Campaign Targeting Hispanic, African-American and General-Market Moms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... -- Two sisters in high school have developed ways ... Medha Krishen use electronic stethoscopes, which electronically amplify body ... patterns or heartbeats. Ilina, a senior at Port ... a way to detect early lung damage in people ... Ilina recorded one breath cycle each from 16 smokers, ...
(Date:10/22/2014)... Salamon HealthDay Reporter TUESDAY, ... conventional in vitro fertilization (IVF) -- the incubation of embryos ... a device inside the vagina, new research suggests. Scientists ... called an INVOcell, might sharply cut costs for pricey IVF ... more accessible to those who don,t live near big-city assisted ...
(Date:10/22/2014)... Thompson HealthDay Reporter , MONDAY, ... Monday officially tightened guidelines for health workers treating Ebola patients, ... use of a respirator at all times. The U.S. ... tougher rules after two Dallas nurses contracted Ebola while caring ... Liberian national Thomas Eric Duncan. Nina Pham is currently being ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 The newly ... must-have source of thousands of facts, figures and forecasts ... and 68 medical sector forecast categories the Worldwide ... global, regional and national views on the worldwide medical ... , The report gives you data for 2010-2019, covering ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute ... to repair a damaged mitral valve as the heart ... developed by Abbott Vascular , is designed to ... condition in which the heart’s mitral valve leaflets fail ... the heart’s left ventricle into the left atrium. The ...
Breaking Medicine News(10 mins):Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... THURSDAY, Nov. 24 (HealthDay News) -- Higher doses of ... people suffering from aggressive lymphomas, such as diffuse large ... forms of non-Hodgkin,s lymphoma), according to new research. ... Lancet found this intensive form of chemotherapy, when ...
... , FRIDAY, Nov. 25 (HealthDay News) -- ... the mental health of black adults in the United ... 66 previous studies that included more than 18,000 black ... racism and trauma, including somatization (psychological distress that is ...
... , FRIDAY, Nov. 25 (HealthDay News) -- The sudden return ... cause some people to go into a funk, but an ... of the holidays year-round. "A large part of happiness ... holidays offer punctuated moments of joy we look forward to ...
... should be able to choose where they give birth, concludes ... first-time mums who opt for a home birth are at ... low in all birth settings. The researchers say their ... pregnancies a choice of birth setting" and will enable women ...
... Nov. 23 (HealthDay News) -- A 36-year-old husband and father ... (windpipe) has received the world,s first artificial trachea made with ... in The Lancet described the transplant surgery, which ... Stockholm, Sweden. Without the transplant, the authors of the ...
... HealthDay Reporter , WEDNESDAY, Nov. 23 (HealthDay News) ... enhanced quality of life may have hidden problems that could ... A letter to the editor in the Nov. 24 ... reports severe bleeding complications among trauma patients on the anti-clotting ...
Cached Medicine News:Health News:More Aggressive Chemo May Help Younger Lymphoma Patients: Study 2Health News:More Aggressive Chemo May Help Younger Lymphoma Patients: Study 3Health News:How to Extend Holiday Cheer 2Health News:Pregnant women at low risk of complications can safely be offered a choice of where to give birth 2Health News:1st Artificial Windpipe Made With Stem Cells Seems Successful 2Health News:Newer Blood Thinner May Pose Danger to Trauma Patients 2Health News:Newer Blood Thinner May Pose Danger to Trauma Patients 3
(Date:10/22/2014)...  Early symptoms of diabetic eye and vision ... technology, coupled with yearly, comprehensive eye exams, are ... of eye diseases, including those associated with diabetes, ... untreated, these diseases can potentially lead to vision ... optometric researchers have deployed a new tool that ...
(Date:10/22/2014)... -- InVivo Therapeutics Holdings Corp. (OTCQB: NVIV) based in ... cord injury (SCI) treatment with their novel Neuro-Spinal Scaffold. ... regrowth in the spinal cord area when cells are ... polymer, the scaffold ultimately breaks down to water and ... NVIV has recently attracted significant investor attention with the ...
(Date:10/22/2014)... YORK , Oct. 22, 2014 Provectus ... dermatology therapies. PV-10, its novel investigational drug for cancer, ... potential for systemic side effects. Its oncology focus is ... Provectus has completed phase 2 trials of PV-10 as ... a topical treatment for atopic dermatitis and psoriasis. ...
Breaking Medicine Technology:Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3Provectus Biopharmaceuticals Looks at the Asian Markets: Analyst Coverage by Small Cap Traders 2
... Inc., the largest,privately held spinal implant manufacturer in ... Spacers have been implanted under an,Investigational Device Exemption ... II and Dr. Rhett Murray., The FLEXUS(TM) ... two,spinous processes with minimal disruption to the surrounding ...
... (BiTE) showing clinical benefit in cancer,patients; Blinatumomab enables patients own T ... ... cancer cells, BETHESDA, Md., Aug. 14 Micromet, Inc.,(Nasdaq: ... treatment of cancer, inflammation and autoimmune,diseases, today announced publication of a ...
Cached Medicine Technology:First FLEXUS(TM) Interspinous Spacer Surgeries for IDE Clinical Trial 2Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab 2Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab 3Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab 4Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab 5Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab 6
Double-ended. Sharp and blunt 6.5 mm tips. Designated most popular model or size....
Octagonal handle. 3 mm wide....
Desmarres Retractor Size 4...
2.0 mm cup , straight shaft, Flat handle, length 125.0 mm....
Medicine Products: