Navigation Links
Targeting oxidized cysteine through diet could reduce inflammation and lower disease risk
Date:3/27/2009

Iyer and immunologist Mauricio Rojas, MD, found that a high level of oxidized cysteine drives white blood cells to send out inflammatory messages in the form of the protein IL-1 beta.

The researchers used a mouse model of sepsis to test the effects of dietary cysteine on reducing inflammation. They treated the mice with LPS, which mimics the inflammatory effect of bacteria on the human immune system and causes an increase in the level of IL-1 beta. When they supplemented the diet of the mice with cysteine, however, IL-1 beta levels dropped, thus blunting the impact of a sepsis-like inflammation.

In a subsequent study of healthy, but overweight adult volunteers with an average age of 62, IL-1 beta levels also rose and fell in association with the amount of dietary cysteine.

"Our research shows a direct mechanistic link between the oxidative stress biomarker (cysteine redox potential) and pro-inflammatory cytokines, which have been linked to multiple age-related and chronic diseases," says Jones. "Our group and others have already established that cysteine redox potential is oxidized with aging and with a number of health risk factors. This suggests that one could target cysteine redox potential as a means to decrease chronic proinflammatory signaling as an intervention for age-related diseases and for the acute inflammation of sepsis or lung injury."

The researchers plan to continue studying the relationship between cysteine and markers of inflammation in different age groups, in overweight and normal weight individuals and in critically ill patients requiring intravenous feeding.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Deadly in Pink: New Report Warns Big Tobacco Has Stepped Up Targeting of Women and Girls
2. Targeting the protein AEG1 impairs human liver cancer growth in mice
3. Tobacco Companies Targeting Teens, Study Says
4. APIC 2009 Targeting Zero Initiative Offers Practical Tools, Evidence-Based Elimination Strategies to Prevent the Deadliest Healthcare-Associated Infections
5. Targeting Cancers Own Stem Cells to Fight Recurrence
6. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
7. Health Care Service Corporation Finds Success With Innovative Program Targeting Obesity Epidemic
8. Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Anti-Viral Applications of Phospholipid-Targeting Antibodies
9. EGFR-targeting antibody licensed to Abbott
10. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
11. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Victorian Hotel recently celebrated Valentine’s Day ... wanted to spend the auspicious day together. This Vancouver ... jump on Valentine’s Day with a sweet overnight package, ... their luxurious rooms. , The hotel started its ... a mouthwatering 3 course meal at Café 335. This ...
(Date:2/27/2015)... The UC Davis Huntington’s Disease Center, ... it a beacon of hope for people with Huntington’s ... by the national society committed to the values that ... of America — as a Level 1 Huntington’s Disease ... center’s service to over 300 families coping with Huntington's ...
(Date:2/27/2015)... “ Logical Operations ” was featured ... which takes a look at the latest and coolest ... a special reporter for NewsWatch and a technology expert, ... company helps companies avoid cyber security threats. , If ... see cyber security somewhere in the headlines. Well, cyber ...
(Date:2/27/2015)... Mirena IUD lawsuits ( http://www.mirenalawsuit2014.com/ ) ... perforations and other serious harm due to spontaneous migration ... in the multicounty litigation underway in New Jersey’s Bergen ... records indicate that the proceeding’s 34th Case Management Order ... that same day. (In Re: Mirena Litigation; Case No. ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Jupiter Medical ... pioneering partnership, Mount Sinai Heart New York at Jupiter ... research in South Florida. , “This innovative collaboration ... way we’re delivering unparalleled health care in our very ... Executive Officer of Jupiter Medical Center. “This kind of ...
Breaking Medicine News(10 mins):Health News:Victorian Hotel Celebrated Valentine’s Day in 2015 With Unique Overnight Deal 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 3Health News:A Way for Companies to Avoid Cyber Security Threats was Featured on NewsWatch Television on January 30, 2015 2Health News:Mirena Lawsuits Progress in New Jersey with Issuance of New Case Management Order, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuits Progress in New Jersey with Issuance of New Case Management Order, Bernstein Liebhard LLP Reports 3Health News:Jupiter Medical Center and Mount Sinai Heart New York Announce Landmark Partnership 2Health News:Jupiter Medical Center and Mount Sinai Heart New York Announce Landmark Partnership 3Health News:Jupiter Medical Center and Mount Sinai Heart New York Announce Landmark Partnership 4Health News:Jupiter Medical Center and Mount Sinai Heart New York Announce Landmark Partnership 5
... 8-year-old boy,living with epilepsy, and his mother Amy receive ... the exclusive sponsor of Canine,Assistants seizure response dogs. Through ... to play sports, take,music lessons, and learn Tae Kwon ... when his parents are not around is still a ...
... quick, non-invasive identification of the dangerous disease , , WEDNESDAY, ... be able to accurately, rapidly, and non-invasively diagnose lung ... the mouth, a new study suggests. , Oral cavity ... to be a highly accurate indicator of similar lung ...
... Mass., April 16 Xceed Molecular, a ... analysis,systems, announced that the University of Florida ... work with primary researchers,Charles Joel Rosser, MD ... of Surgery), to perform initial verification and ...
... Required to Provide Calorie Information, ALEXANDRIA, Va., ... today,s federal court ruling upholding,a New York City ... content of foods on their menus and menu ... to the regulation filed by the New York ...
... MONICA, Calif., April 16 Consumer,Watchdog today joined ... lawsuit alleging that health insurer Blue Cross engaged ... insurance of patients,after they got sick., The ... at least hundreds,of patients who have been left ...
... 16 MedCath Corporation,(Nasdaq: MDTH ) announced today ... of Directors., Mr. Grossman brings a wealth of ... Directors. He served as partner and health care,practice leader ... years with the firm. While with Pricewaterhouse Coopers, he ...
Cached Medicine News:Health News:Young Boy With Epilepsy to Gain Independence With New Seizure Response Dog From Canine Assistants 2Health News:Mouth Swab May One Day Diagnose Lung Cancer 2Health News:Mouth Swab May One Day Diagnose Lung Cancer 3Health News:Xceed Molecular Signs University of Florida to Strategic Collaborator Program; Focus on Developing New Molecular Test to Diagnose Early-Stage Bladder Cancer 2Health News:Xceed Molecular Signs University of Florida to Strategic Collaborator Program; Focus on Developing New Molecular Test to Diagnose Early-Stage Bladder Cancer 3Health News:Statement of the American Diabetes Association Supporting Federal Court's Ruling on New York City Proposal 2Health News:Consumer Watchdog Applauds L.A. City Attorney's Efforts to Reinstate Cancelled Blue Cross Patients; Urges State HMO Regulator to Do Same 2Health News:Woodrin 'Woody' Grossman Appointed to MedCath's Board of Directors 2
(Date:2/27/2015)... , Feb. 27, 2015  Two ... increasing in applications as their effectiveness is ... Kalorama Information.  Kalorama Information says that while ... the most powerful tool in proteomic biomarker ... MS) through its traditional techniques has struggled ...
(Date:2/26/2015)... Ill. , Feb. 26, 2015  AbbVie ... 15 abstracts of studies in its neuroscience and ... during the 67 th American Academy of ... , from April 18-25. The accepted abstracts ... DUOPA, in addition to investigational treatments in AbbVie,s ...
(Date:2/26/2015)... 26, 2015  Mail-service and specialty pharmacies will ... and government health plans $23.3 billion over the ... Pharmaceutical Care Management Association (PCMA). "Home ... of the easiest ways to reduce health costs," ... . "Policymakers should resist efforts to restrict these ...
Breaking Medicine Technology:Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 2AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 3AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 4AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 5AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 6AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 7PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Texas Employers, Consumers and Public Programs by $23.3 Billion 2
... breadth of infectious disease ELISA products make ... standard assay protocols for faster integration into ... products provide increased reliability and run-to-run consistency. ... detection assays for a wide range of ...
... We offer a complete ... bringing laboratorians state-of-the-art monoclonal and ... the detection of enteric pathogens ... includes products for Clostridium difficile, ...
... The C. Difficile Tox A/B II ... Professional Diagnostics's exclusive Fecal-Quik-Prep device which greatly ... stool specimens for Tox A/B II testing. ... preparation/transfer device that greatly reduces the amount ...
... products for autoimmune testing feature single-well ANA ... as specific reflex tests including dsDNA, and ... (Ro), SS-B (La), Scl-70 and Jo-1. In ... full line of products for Cardiolipins (IgA, ...
Medicine Products: