Navigation Links
Targeting leukemia cell's gene 'addiction' presents new strategy for treatment
Date:3/3/2010

An international team of scientists studying acute forms of Leukaemia have identified a new drug target to inhibit the genes which are vital for the growth of diseased cells. The research, reported in EMBO Molecular Medicine, reveals how leukaemia cells become 'addicted' to genes, which if targeted could prevent diseased cells from developing.

The team, led by Dr Veronika Sexl from the University of Vienna, carried out their research on acute lymphoid leukaemia (ALL) and chronic myelogenous leukaemia (CML), which can both be caused by fusion protein, Bcr-Abl, created through the joining of two or more genes originally coded for separate proteins.

This joining of genes results in a complex tumor supporting 'network' which supports the growth and survival of the leukaemic cells. Inhibitor drugs such as 'Imatinib' can block vital signals and lead to leukemia cell death, but there are several mutations which can resist these inhibitors, making them ineffective.

As an alternative strategy the team investigated transcription factors Stat3 and Stat5 which are linked to bcr/abl-induced transformation. The team tested whether Stat3 and Stat5, acting downstream of Bcr-Abl are critical for leukaemia maintenance and if they could be a alternative target for treatment.

"We developed a tumour-specific gene-deletion approach to analyse the roles of Stat5 and Stat3 in Bcr/Abl-induced leukaemia growth," said Sexl. "We discovered that both factors are required for the development of Bcr-Abl, but once established only Stat5 is crucial for the survival and growth of leukemic Cells."

Even mutated forms of bcr-abl, Leukaemia cells, which are resistant to inhibiting drugs such as Imatinib, are still dependent on Stat5.

"Cancer cells undergo extensive adaptations in their signalling and metabolic pathways, thereby becoming dependent on certain genes," said Sexl. "In fact the activity of these genes can become limiting for a cancer cell."

The term 'Non-oncogene addication' (NOA) has been coined to describe this phenomenon of gene dependency and inhibiting these critical genes within the signalling network is predicted to cause system failure and halt the growth of leukaemia cells.

"In this study we demonstrated that bcr-abl, Leukaemia cells are addicted to Stat5 to maintain the leukameic state, concluded Sexl. "We've identified Stat5 as an Achilles' heel in the signalling network downstream of Bcr-Abl. Thus, inhibition of Stat5 may provide a novel therapeutic approach for treatment of leukaemia."


'/>"/>

Contact: Ben Norman
Lifesciencenews@wiley.com
44-124-377-0375
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
2. Hacker Attacks Targeting Healthcare Organizations Doubled in the 4th Quarter of 2009 According to SecureWorks Data
3. Targeting cancerous vessels
4. Targeting brain cancer cell metabolism may provide new treatment
5. With White House Jobs Summit This Week KSBH Unveils New TV Ads Targeting Senators on Health Care
6. First live targeting of tumors with RNA-based technology
7. Wistar researchers show targeting normal cells in tumors slows growth
8. Success Targeting Competencies Missed in Traditional Testing Leads to Selection of Amistaff for Poster Presentations on Prophecy's Video-Based Situational Assessments
9. DNA test could be key to targeting treatments for head and neck cancer
10. Another Report Finds Swine Flu Targeting the Young
11. Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... Michigan (PRWEB) , ... August 16, 2017 , ... The ... are now being accepted. , Students who successfully complete the seven-week long Patient ... Certified Nurse Assistant (CNA). The average starting salary for a CNA in Kalamazoo is ...
(Date:8/16/2017)... ... 16, 2017 , ... Ten outstanding teachers in the Greater Houston area will ... win a visit by a Houston Texans player, two tickets to a Texans game, ... old can visit texanschecking.com/stars to nominate their favorite teacher with an essay of no ...
(Date:8/16/2017)... ... August 16, 2017 , ... In ... They celebrate 30 years in business this year, and they’re marking the milestone ... space to serve their patients. , It stands to reason that, given ...
(Date:8/16/2017)... ... August 16, 2017 , ... Maury Regional Health has announced a ... By broadly deploying AccuVein devices, Maury Regional Medical Center is making vein visualization part ... of a needle stick and more importantly, helps our staff members locate a vein ...
(Date:8/16/2017)... ... 16, 2017 , ... A global leader in the treatment of clubfoot, ... 29 Indian states—bringing the country one step closer to eliminating clubfoot as a lifelong ... is on track to enroll 10,000 children in the clubfoot treatment program in this ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
(Date:8/4/2017)... Aug. 4, 2017 The search for test ... a physician/patient consult has long been the goal of ... notable focus of the largest meeting of lab professionals ... healthcare market research firm Kalorama Information.  The firm said ... offerings or related supplies and software were at the ...
(Date:8/2/2017)... AURORA, Ore. , Aug. 2, 2017  Life Flight ... Call Agreement. The agreement improves patient care and operational efficiency ... Springfield , Cottage Grove ... ICU level medical transportation. PeaceHealth and Life Flight Network work ... care available during transport, or when a time sensitive emergency ...
Breaking Medicine Technology: