Navigation Links
Targeting innate immunity in malaria
Date:8/4/2011

dy, we set out to understand what role the innate immune system plays in this fever response, the dominate symptom found in malaria patients."

Looking at blood samples from febrile malaria patients, Fitzgerald and colleagues found the typical genetic signs expected from patients infected by a pathogen. What they weren't expecting to find, however, were elevated levels of interferon-expressing genes. Typically produced when a virus is detected, interferon triggers the protective defenses of the immune system that can eradicate viruses or tumors. "What we saw when we looked at the samples from malaria patients was a type 1 interferon signature in the immune cells that were responding to the malaria," said Fitzgerald. "This surprised us at the time because traditionally we thought of interferon only in the context of virus infections"

Working with Douglas T. Golenbock, MD, chief of the Division of Infectious Diseases and Immunology at UMMS, Dr. Fitzgerald and colleagues set out to find what was triggering the innate immune response and what effect that response was having on the host cells. What they found was a part of the malaria genome containing a dense portion of the nucleic acids adenine and thymine, two of the building blocks in DNA, which were responsible for activating a novel signaling pathway, including STING, TBK1 and IRF3-IRF7, in the host that enabled innate immune cells to produce type 1 interferon.

When Fitzgerald and colleagues proceeded to test the importance of this pathway to the progression of the disease in small animal models they found another surprise. Those which expressed the normal STING, TBK1 and IRF3-IRF7 pathway all succumbed to the infection within 12 days. However, those that lacked some or all of these genes survived the infection, suggesting that this novel DNA-sensing pathway that leads to type 1 interferon production may play a vital role in the progression of malaria in the host.

"Normally inter
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Targeting PTEN may prevent skin cancer
2. Targeting the Ewing sarcoma family of tumors
3. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
4. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
5. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
6. Targeting top 911 callers can trim cost, improve patient care
7. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
8. New program targeting whole-person health care gets major grant
9. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
10. Scientists announce new advance with potential for future cancer targeting
11. Investment in CRC screening targeting pre-medicare population could cut medicare treatment costs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... 2015 The Hon. Ellen Tauscher, Independent ... the following statement following the deadly earthquake in Nepal: ... resulting in the deaths of more than 1,000 people. ... across Nepal, Bangladesh, India and other parts of South ... to the people of Nepal and the families of ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 Carinsurancequotesinfo.com has ... find low cost auto insurance for flatbed ... heavy goods and sometimes other vehicles. They are mainly ... insurance. The newly released blog post explains that by ... for trucks, vans and other commercial vehicles. , It ...
(Date:4/25/2015)... 25, 2015 An expanded and newly ... of successfully welcoming visitors to the Turks and Caicos ... As part of a major construction project occurring in ... redesigned to speed up arrivals. A new exterior ... out of the airport and onto Grace Bay beach! ...
(Date:4/25/2015)... New York (PRWEB) April 25, 2015 The ... Dr. Jerry Blaivas has been chosen by the New York ... his contributions to medicine in the field of Urology. , ... best in his speciality, Genito-Urinary diseases. He was a ... in the field of urology. Not only did he ...
(Date:4/25/2015)... 2015 For thirteen years, the Twin Cities ... education event in the nation! This year, on May 5th, ... US to take DI Day on the road by supporting ... CLU, ChFC, RHU, DIA, CLTC, Chief Executive Officer at Secura ... on the change by stating, "The first Twin Cities DI ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Secura Consultants Takes DI Day On The Road 2
... words today throughout the country are 'Dengue' and ... the bite of an infected// Aedes aegypti female ... states. Dengue is the most common mosquito-borne viral ... administrative machinery is battling with a situation that is threatening ...
... normally used to treat ulcers, was found to prevent ... women in developing countries, according// to a study conducted ... India's Jawaharlal Nehru Medical College, and the National Institutes ... Oct. 8 issue of Lancet, found misoprostol reduced the ...
... pregnant women suffering from malaria was found to be safe ... and at the London School of Hygiene & Tropical Medicine ... the malarial parasite without any serious side effects in the ... only with the drug amodiaquine or in combination with sulphadoxine-pyrimethamine ...
... of bowel cancer is greater among women than among men ... a Sydney study that was carried on 1200 bowel cancer ... likely to die from their disease compared to males. On ... aged 50 and under actually had a better survival rate ...
... of stroke in Perth, Western Australia by 43% over the ... George Institute for International Health at the Annual Scientific Meeting ... ,Stroke affects around 17 million people globally and is ... Nationally, over 53,000 strokes occur each year, of which one ...
... in the HIV/AIDS prevalence rate in Kenya from 6.1% in ... Control Council of Kenya (NACC) released the latest data, according ... 9.6 % whereas in rural areas it is 4.6%.,A variety ... preventing pregnant HIV-positive mothers from passing the virus to their ...
Cached Medicine News:Health News:Dengue and Chikungunya: The Dirge of a Nation 2Health News:Dengue and Chikungunya: The Dirge of a Nation 3Health News:Dengue and Chikungunya: The Dirge of a Nation 4Health News:Ulcer Drug Could Save Lives of Women in Developing Countries 2Health News:New method to treat malaria in pregnant women 2Health News:Increased Risk of Bowel cancer after Menopause 2Health News:Declining Incidence of stroke in Australia 2Health News:Decrease in AIDS prevalence rate in Kenya 2
(Date:4/24/2015)... -- Introduction of new "Elements" ... for radiosurgery/SBRT   The "Elements" strategy ... the workflow for difficult to treat indications in ... comes full circle with the introduction of automated ... enable on-the-fly generation of consistent treatment plans for ...
(Date:4/24/2015)... T-Bird Pharma Inc. (TSXV:TPI) ("T-Bird" or the "Company"), a ... products and a licensed producer ("LP") to cultivate marijuana ... Canada ) ("MMPR"), is pleased to announce that ... the transaction announced on March 11, 2015 with Medna ... a total of 20,156,790 common shares of T-Bird (45% ...
(Date:4/23/2015)... Lifesciences Corporation (NYSE: EW ), the global leader ... today reported net income for the quarter ended March 31, ... Net income for the same period a year earlier ... non-GAAP net income was $82.1 million, or $0.76 per ... ended March 31, 2015 increased 13.0 percent to $590.3 million ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3Edwards Lifesciences Reports First Quarter Results 2Edwards Lifesciences Reports First Quarter Results 3Edwards Lifesciences Reports First Quarter Results 4Edwards Lifesciences Reports First Quarter Results 5Edwards Lifesciences Reports First Quarter Results 6Edwards Lifesciences Reports First Quarter Results 7Edwards Lifesciences Reports First Quarter Results 8Edwards Lifesciences Reports First Quarter Results 9Edwards Lifesciences Reports First Quarter Results 10Edwards Lifesciences Reports First Quarter Results 11Edwards Lifesciences Reports First Quarter Results 12Edwards Lifesciences Reports First Quarter Results 13Edwards Lifesciences Reports First Quarter Results 14Edwards Lifesciences Reports First Quarter Results 15Edwards Lifesciences Reports First Quarter Results 16
... spinal company continues to focus on unmet needs of the lumbar ... ... disc, MINNEAPOLIS, May 1 CoreSpine Technologies, LLC, an,emerging spinal ... implant procedures to include an application,for minimally invasive fusion., The ...
... predict life-long tendency to inflammation ... related cardiovascular event risk profile, WALTHAM, Mass., May ... announced publication of the results of clinical,studies that support ... The article, titled, "IL1B Gene Promoter Haplotype,Pairs Predict Clinical ...
Cached Medicine Technology:CoreSpine Technologies Expands Spinal Disc Site Preparation Efforts 2Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 2Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 3Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 4Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 5
... Unparalleled Comfort Pick one of our pipettors ... the trigger and ejector positionsright where they should ... are ergonomically designed to help avoid repetitive stress ... Productivity In The Palm Of Your Hand ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... The total ergonomic solution and best value ... feather touch action and ultra lightweight design ... tip ejection with long, lever tip ejector ... , Accepts universal tips or for greater ...
Medicine Products: