Navigation Links
Targeting hit-and-run cancer viruses
Date:8/18/2010

Viruses that can invade host cells, initiate cancer and then flee from their own trail of destruction could be stopped in their tracks, say researchers writing in the September issue of the Journal of General Virology.

Scientists at the University of Cambridge have not only provided the first unequivocal evidence for the 'hit-and-run hypothesis' - explaining how some viruses might cause cancer and then mysteriously disappear - but have also shown how a vaccine could arrest them. Equivalent vaccines could help prevent not only known virus-induced human cancers, such as Burkitt's lymphoma, but also cancers currently unsuspected of having a viral origin.

The team experimented with a mouse herpesvirus - similar to the human EpsteinBarr virus that causes Burkitt's lymphoma. The virus was engineered to trigger oncogenic changes at high frequency in infected cells, leading to cancerous tumour growth. Surprisingly, the cancers soon lost any sign of their previous viral infection. The group went on to show that vaccinating the mice with a modified version of the same virus protected them against subsequent cancer development.

Drs. Philip Stevenson and Stacey Efstathiou, who led the study, explained how some viruses that establish 'latent' infections (enabling them to persist in host cells without activating the immune system), cannot necessarily maintain those infections in cancer cells. This means they can initiate cancers or play a role in their development, but then can disappear from tumour cells by the time the cancer is clinically detected.

They believe that immunisation against such viruses could be an effective and relatively simple means of preventing some cancers - much as vaccination is being used to protect women against cervical cancer caused by the human papillomavirus (HPV).

However, the team's findings highlight that the link between viruses and cancer is not necessarily straightforward. "We have shown that some cancer-initiating viruses may subsequently leave the cell without trace, meaning that some viruses may contribute to more human cancers than suspected," said Dr Stevenson. "The positive side of this is that developing an effective vaccine against oncogenic herpesviruses could prevent more cancers than might be estimated from those carrying viral genomes," he said.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related medicine news :

1. Targeting flight-or-fight hormone response to combat heart failure
2. Targeting disease remission has socio-economic benefits over low disease activity
3. Spanish gene expression data promise targeting of anti-angiogenesis treatment
4. Targeting the blood-brain barrier may delay progression of Alzheimers disease
5. New Study on Elder Care Marketing Reveals Fresh Insights in Targeting Aging Population
6. Age Management Leader Goes Beyond 2010 NANES Study Reqs, Targeting Heightened Obesity Group, Adult 40+
7. Targeting cell pathway may prevent relapse of leukemia
8. Diversinet Extends Reach of Mobile Healthcare Information With New Product Release Targeting Healthcare Organizations
9. Targeting blood vessels, immune system may offer way to stop infection-caused inflammation
10. Americans for Responsible Health Care Launch Radio Ads Targeting Seven Democrats, Warning The People Are Watching...
11. Targeting leukemia cells gene addiction presents new strategy for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... FL (PRWEB) , ... March 24, 2017 , ... ... Inc. ( http://www.hygieacare.com ) announced their partnership to prep patients for colonoscopy at ... Endoscopy Centers in 87th Ave., Miami, FL. , The HyGIeaCare® ...
(Date:3/24/2017)... ... 2017 , ... “Finding Christ Through Social Media: Year One ... the writer’s path toward true communion with God. “Finding Christ Through Social Media: ... creation of published author Lea Michelle Johnson, a follower of Christ, wife and ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of ... people of God in congregations across the United States. “The Communion of ... in 1964 who has served congregations in seven states throughout his long career ...
(Date:3/23/2017)... CO (PRWEB) , ... March 23, 2017 , ... A ... bar for entry into teacher preparation programs. The NCTQ report suggests, based on a ... entry requirements would significantly improve teacher quality in the U.S. It argues that this ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... Texas ... located at 960 Gruene Road in Building 2. The clinic is the group’s second ... Bennett, PT, says opening the company’s second New Braunfels location brings things full circle ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... The key factors driving the growth of dialysis ... growth and increasing healthcare expenditure. Some of the noteworthy trends ... ESRD patients, rising demand for home PD treatment and huge ... market is hindered by high treatment costs and stringent regulations. ... Complete ...
(Date:3/23/2017)... BARBARA, Calif. and INDIANAPOLIS ... (NYSE: LLY ) and the William Sansum ... the lives of Latino people affected by diabetes through ... tremendous burden of diabetes and cardiovascular disease bears a ... United States ," said David Kerr , ...
(Date:3/23/2017)... , March 23, 2017   BioSpace , ... resource, has partnered with Indiana Biosciences Research Institute ... organizations and educational institutions to bring the state,s ... first-ever BioIndiana Hotbed map, an artistic representation of the ... was presented to Vice President Mike Pence , ...
Breaking Medicine Technology: