Navigation Links
Targeting flight-or-fight hormone response to combat heart failure
Date:6/24/2010

disease strain-related thickening of muscle tissue (hypertrophy) and scar tissue formation (fibrosis). Both compounds partially normalized the force of heart muscle contraction by making sure the beta adrenergic receptors became and remained responsive to adrenalin. This was done by both decreasing overall levels of GRK2 in the heart and by limiting its effectiveness.

M119 and Gallein have been used in a similar way in the past to target the receptor desensitization process that occurs in other conditions, such as chronic pain. For example, Smrcka and his collaborator Jean Bidlack, Ph.D., professor of Pharmacology and Physiology at the Medical Center, have shown M119 can reverse the desensitization of opiate receptors, which in turn increases the efficacy of painkillers such as morphine. M119 and Gallein are not known drugs; they are compounds that act as dyes, or stains, and were previously not known to have any therapeutic activity.

This research addresses a health problem that affects nearly 6 million Americans. The result of underlying problems like coronary artery disease, high blood pressure or heart attack damage, heart failure is the gradual loss of the heart's ability to pump with enough force to meet the body's need for blood. Half of patients will not live five years past the day they are diagnosed. The best treatment for a severe heart failure patient is a transplant, but with just over 2,000 transplants done each year and more than 3,000 people on the waiting list at any given time, research like this is needed to find new options for patients.


'/>"/>

Contact: Emily Butler
emily_butler@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hacker Attacks Targeting Healthcare Organizations Doubled in the 4th Quarter of 2009 According to SecureWorks Data
2. Targeting brain cancer cell metabolism may provide new treatment
3. With White House Jobs Summit This Week KSBH Unveils New TV Ads Targeting Senators on Health Care
4. First live targeting of tumors with RNA-based technology
5. Targeting cancerous vessels
6. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
7. Targeting leukemia cells gene addiction presents new strategy for treatment
8. Americans for Responsible Health Care Launch Radio Ads Targeting Seven Democrats, Warning The People Are Watching...
9. Targeting blood vessels, immune system may offer way to stop infection-caused inflammation
10. Diversinet Extends Reach of Mobile Healthcare Information With New Product Release Targeting Healthcare Organizations
11. Targeting cell pathway may prevent relapse of leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... 03, 2015 Come on out in ... a 200-mile overnight relay beginning in Madison, Wisconsin on ... Saturday, June 13th. , For the 4th consecutive year, ... will run to raise money for the Brain Aneurysm ... members of the Neurosurgery staff from The University of ...
(Date:6/3/2015)... (PRWEB) June 03, 2015 Unfortunately, a majority ... it comes to providing comfort to the users throughout the ... brand or one from the local market, the makers generally ... and, in the process, often overlook comfort and health. To ... of shoe, the creative heads at Vay Technologies have come ...
(Date:6/3/2015)... Israel (PRWEB) June 03, 2015 evigilo, ... multi-channel solutions, has showcased its new branding by launching ... , "The new brand identity: the logo depicting ... red, to green, the tagline – To Know. To ... new path evigilo is charting. A global, borderless approach ...
(Date:6/2/2015)... June 02, 2015 Allred Dental, a dental ... for the months June-September, 2015 along with a $100 off ... limited time only. , “Sometimes wisdom teeth can be impacted, ... jawbone. They can also only partially break through the gum, ... recovery is easier in young people, as they do not ...
(Date:6/2/2015)... Pleasant Prairie, WI (PRWEB) June 03, 2015 ... suited for regulated industries such as government, finance and ... any organization that wants reliable access control to enhance ... smart card keyboard requires the secondary authentication of a ... In addition to the smart-chipset card reader, the ...
Breaking Medicine News(10 mins):Health News:4th Annual Ragnar Relay from Madison, WI to Chicago, IL Once Again Benefits Renowned Brain Aneurysm Foundation 2Health News:Vay Technologies Launches uGALE the High Tech Insole Technology for Shoes on KickStarter 2Health News:Vay Technologies Launches uGALE the High Tech Insole Technology for Shoes on KickStarter 3Health News:Keep calm! evigilos' "sun" will come out tomorrow – to know, to act, in time. 2Health News:$100 Off Coupon for Wisdom Teeth Extractions Offered at Allred Dental 2Health News:Introducing the New CHERRY JK-A0100EU Keyboard with Integrated Smart Card Reader for Access Control Security 2
... care , , WEDNESDAY, Nov. 5 (HealthDay News) -- Scientists ... of individuals, an Asian man and an African man, ... , The analysis of the DNA of the two ... care designed for each person,s genetic makeup is close ...
... AUGUSTA, Ga. The Medical College of Georgia announced ... Explorations grant from the Bill & Melinda Gates Foundation. ... research project conducted by Dr. Pandelakis A. Koni titled ... Dr. Koni,s project is one of 104 grants recently ...
... Examination Management,Services, Inc. (EMSI), a leading provider ... record retrieval services, announced today,that it has ... of sales for,Healthcare Services. In this role, ... and strategic partners to increase sales and ...
... 5 One of Fayette,County,s largest employers will expand ... of an $8.4 million, 20-year investment by the commonwealth., ... year through the,Fayette County Redevelopment Authority, on behalf of ... The funds will be used to jump start the ...
... Systems, Inc,(MPS) has signed a contract with Meadowview ... first facility in the state. The company is,now ... Pennsylvania,Maryland, Delaware, and West Virginia., Traci Henderson, ... than others and offered a connection to the,pharmacy ...
... for Corporate Support in Fighting Childhood Cancer and ... This year you can wear your,Halloween costume twice and ... with cancer who need help in paying medical bills ... out in their,favorite super hero costumes at this year,s ...
Cached Medicine News:Health News:Two More Human Genomes Mapped 2Health News:MCG receives $100,000 Grand Challenges Explorations grant for innovative global health research 2Health News:Groseth Rejoins EMSI to Lead Healthcare Services Sales 2Health News:State to Invest $8.4 Million in Uniontown Hospital's Expansion 2Health News:Millennium Pharmacy Systems Expands into West Virginia 2Health News:Super Jake Foundation Hosts 4th Annual 'Heroes Bash' on Nov. 8 to Benefit Pediatric Cancer Research 2Health News:Super Jake Foundation Hosts 4th Annual 'Heroes Bash' on Nov. 8 to Benefit Pediatric Cancer Research 3
(Date:6/2/2015)... Today, the world,s largest and fastest provider ... more transparent, the importance of websites continues to grow ... maxim of "innovation brings progress and changes thinking" will ... The company has long been recognised as an international ... and modern approach, while also repeatedly breaking new ground ...
(Date:6/2/2015)... June 2, 2015  University Hospitals (UH) ... Cleveland area to implant a new miniaturized, ... HF System is the first and only FDA-approved heart failure ... admissions when used by physicians to manage heart failure., ... that is implanted in the pulmonary artery (PA) during a ...
(Date:6/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/d8nj6b/europe ) has announced ... Growth, Trends And Forecasts (2014 - 2019)" report ... Fluoroscopy is expected to grow at a healthy CAGR ... to view the gastrointestinal tract, to direct the movement ... the urinary system, to open narrowed or blocked blood ...
Breaking Medicine Technology:UH Case Medical Center becomes first in region to offer patients a new heart failure monitoring solution 2UH Case Medical Center becomes first in region to offer patients a new heart failure monitoring solution 3European Fluoroscopy Market Report 2014-2019 - Growth, Trends And Forecasts 2
... , EAST HANOVER, N.J. , June 3 ... III study of Afinitor® (everolimus) tablets plus best supportive care ... survival, or time without tumor growth, in patients with advanced ... I n A dvanced N euroendocrine ...
... Today, the U.S. Food and Drug Administration (FDA) released final ... a long-acting beta-agonist (LABA).  This follows the FDA communication on 18 ... changes. , , , ... http://www.newscom.com/cgi-bin/prnh/20091027/PH99766LOGO ) , , ...
Cached Medicine Technology:Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors 2Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors 3Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors 4Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors 5Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors 6Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors 7FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 2FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 3FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 4FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 5FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 6
Spectra 3000RS & Spectra 3000RSP are very precise instruments. They have a metal base structure, durable parts for long life use, and they are very easy to use and maintain....
... Series Spectrophotometer is truly ... UV-VIS instrumentation. The latest ... into a radically new ... and performance unprecedented in ...
... the user to quickly and accurately count bacteria ... counting or manual counting. An optional 1.5X auxiliary ... to 3.0X. The adjustable focusing rod allows the ... The lens also rotates a full 360 for ...
The Accucount 2000 is designed to automatically count microscopic objects in a field displaying totals on a highly visible digital readout....
Medicine Products: