Navigation Links
Targeting cholesterol to fight deadly brain cancers
Date:9/15/2011

Blocking the uptake of large amounts of cholesterol into brain cancer cells could provide a new strategy to battle glioblastoma, one of the most deadly malignancies, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.

The study, done in cells lines, mouse models and analysis of tissue from brain cancer patients, uncovered a novel mechanism by which the most commonly activated oncogene, the mutated epidermal growth factor receptor (EGFR), overcomes normal cell regulatory mechanisms to feed large amounts of cholesterol to the brain cancer cells, said Dr. Paul Mischel, a professor of pathology and laboratory medicine and molecular and medical pharmacology, a Jonsson Cancer Center researcher and senior author of the study.

The study appears Sept. 15 in Cancer Discovery, the newest peer-reviewed journal of the American Association for Cancer Research. It shows that EGFRvIII, common in glioblastoma, promotes the import of cholesterol into cancer cells by up-regulating its cellular receptor, the LDL receptor, promoting rapid tumor growth and survival.

There are at least three ways by which cells normally tightly control their cholesterol levels - synthesis, import and efflux, or pumping out the cholesterol, Mischel said.

"Our study found that the mutant EGFR hijacks this system, enabling cancer cells to import large amounts of cholesterol through the LDL receptor," Mischel said. "This study identifies the LDL receptor as a key regulator of cancer cell growth and survival, and as a potential drug target."

Mischel and his colleagues hypothesized that targeting the LDL receptor for destruction could result in strong anti-tumor activity against glioblastoma. They showed that a drug that activates the nuclear Liver X Receptor, a critical regulator of intracellular cholesterol that ensures appropriately balanced levels, degraded the LDL receptor in tumor cells bearing EGFR mutations, potently killing
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Targeting innate immunity in malaria
2. Targeting PTEN may prevent skin cancer
3. Targeting the Ewing sarcoma family of tumors
4. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
5. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
6. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
7. Targeting top 911 callers can trim cost, improve patient care
8. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
9. New program targeting whole-person health care gets major grant
10. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
11. Scientists announce new advance with potential for future cancer targeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 6 Minutes to Skinny , a fat loss ... is showing men and women of all ages how they ... using simple 6-minute exercises and easy-to-follow lifestyle tips daily, has ... , “When it comes to losing body fat, unfortunately ... all people,” reports Michaels. “Metabolism plays a big role in ...
(Date:9/20/2014)... 2014 Increases in household, construction ... waste treatment volumes. However, government regulations and higher ... landfill. According to IBISWorld industry analyst Alen Allday, ... aimed at reducing the volume of waste generated, ... recovered.” Still, a large proportion of waste generated ...
(Date:9/20/2014)... September 20, 2014 As testosterone ... in federal court, Bernstein Liebhard LLP notes that ... (FDA) have voted overwhelmingly to recommend that prescription ... be subjected to further study in order to ... published on September 18th by Bloomberg.com, the panel ...
(Date:9/20/2014)... 2014 (HealthDay News) -- As flu season approaches, the ... to get a flu shot and a checkup, according ... care doctor can vaccinate people against the flu, and ... have. Retail stores may provide flu shots for their ... Dr. Jorge Parada, medical director of infection prevention and ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 As ... http://www.injurybeacon.com/power-morcellator/ ) in gynecological surgeries continue to ... insurer has announced plans to end coverage for ... its website last month, Harrisburg, Pennsylvania-based Capital BlueCross ... 1, 2014. The insurer said its decision was ...
Breaking Medicine News(10 mins):Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Get a Flu Shot During Checkup, Doctor Says 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3
... -- Revenue of $99.7 million, up 23.6% year-over-year or up 30.9% ... of $11.3 million or $0.32 per diluted share, compared to a ... Highlights: -- Revenue of $423.4 million, up 45.5% ... -- Net income of $24.0 million or $0.68 per diluted ...
... Johnson & Johnson/Basilea,s or Forest/Novexel,s Drug Could Be ... Report from AMR and Decision ResourcesMALVERN, Pa. and ... (AMR) and Decision Resources find that activity against ... attributes influencing surveyed physicians, antibiotic selection for the ...
... students react better to stress, are less fatigued, have more ,integrated, brains , , , , , ... , , , ... , , , ... VIDEO: , Fred Travis, lead author and director of MUM,s Center for Brain, ,Consciousness and ...
... The Board of the Walter and Eliza Hall Institute ... the Institute,s next Director.Announcing Professor Hilton,s appointment as Director-Designate, ... that the directorship of WEHI is among the most ... world. This fact had demanded the most rigorous global ...
... ON, Feb. 24 /PRNewswire-FirstCall/ - Nuvo Research Inc. (TSX: ... research and development of drug products delivered to and ... delivery technologies, today announced that Nuvo,s INSIGHT(TM) platform, developed ... fqubed, Inc., has been selected as one of four ...
... Hard-Pressed Business SectorKIRKLAND, Wash., Feb. 24 For people ... healthcare front. They can often insure themselves for less, ... can use company dollars for a tax-deductible plan for ... of the Board of LTC Financial Partners LLC (LTCFP), ...
Cached Medicine News:Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 2Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 3Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 4Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 5Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 6Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 7Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 8Health News:Activity Against Drug-Resistant Pathogens is One of the Leading Attributes Influencing Physicians' Antibiotic Selection for the Treatment of Inpatient Community-Acquired Pneumonia 2Health News:Activity Against Drug-Resistant Pathogens is One of the Leading Attributes Influencing Physicians' Antibiotic Selection for the Treatment of Inpatient Community-Acquired Pneumonia 3Health News:Transcendental Meditation buffers students against college stress: Study 2Health News:Transcendental Meditation buffers students against college stress: Study 3Health News:Transcendental Meditation buffers students against college stress: Study 4Health News:Transcendental Meditation buffers students against college stress: Study 5Health News:The Walter and Eliza Hall Institute Announces the Next Director 2Health News:The Walter and Eliza Hall Institute Announces the Next Director 3Health News:The Walter and Eliza Hall Institute Announces the Next Director 4Health News:Nuvo's High Throughput Experimentation Platform Selected as 2009 Edison Award Finalist 2Health News:Nuvo's High Throughput Experimentation Platform Selected as 2009 Edison Award Finalist 3Health News:Long Term Care Insurance for Business Owners & Executives: Tax Benefits Often Overlooked 2
(Date:9/19/2014)... Mich. , Sept. 19, 2014  Diplomat, the ... of David Dreyer to the Board of ... independent director and will also serve as chair of ... almost 30 years of accounting, financial, compliance and operating ... Mr. Dreyer has served as chief financial officer, chief ...
(Date:9/19/2014)... 2014 According to market ... Mobile, Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, ... Rotary) & Geography - Global Trends & Forecast ... the lyophilization market on the basis of various ... of the market size of each of these ...
(Date:9/19/2014)... , Sept. 19, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... class collagenase-based products marketed as XIAFLEX ® in the ... that BioSpecifics, President, Tom Wegman , will present a ... in the Biotech Industry Conference. The presentation ... p.m. EDT at the Millennium Broadway Hotel in ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2
... Fla., May 8, 2012 Grappling with economic uncertainty, ... industry is on the cusp of major changes, said ... opening session of the 2012 GHX Healthcare Supply Chain ... GPOs and distributors gathered this week in Orlando for ...
... DIEGO, May 8, 2012 Aethlon Medical, Inc. ... filtration devices to address infectious disease, cancer and other ... C virus (HCV) is currently undetectable in all infected ... in combination with peginterferon+ribavirin (PR) drug therapy and monitored ...
Cached Medicine Technology:GHX Reveals Roadmap to Stronger Healthcare Community at GHX Healthcare Supply Chain Summit 2GHX Reveals Roadmap to Stronger Healthcare Community at GHX Healthcare Supply Chain Summit 3Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 2Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 3Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 4Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 5
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: