Navigation Links
Targeting cholesterol may help slow glioblastoma
Date:9/15/2011

PHILADELPHIA Glioblastoma is among the most lethal cancers, but scientists have uncovered a novel growth mechanism that suggests patients with glioblastoma could be treated with cholesterol-lowering agents, according to a study published in Cancer Discovery, the newest journal of the American Association for Cancer Research.

Lead researcher Paul Mischel, M.D., Lya and Harrison Latta professor of pathology and laboratory medicine, and professor of molecular and medical pharmacology at the David Geffen School of Medicine at the University of California, Los Angeles, said the study revealed that EGFR vIII, a known oncogene in glioblastoma, increased the activity of the LDL receptor and, therefore, allowed for large amounts of cholesterol.

"Our data demonstrate that glioblastoma cells need large amounts of cholesterol to grow and to survive. This is not surprising considering the critical role of cholesterol in making new membranes, of which rapidly growing tumors need a lot," said Mischel.

Mischel's work is part of a growing body of cancer research where scientists study how they can combat a tumor's growth supply, rather than the tumor itself. The most familiar agents in this arena are the vascular endothelial growth factor inhibitors, like bevacizumab, which restrict a tumor's blood supply.

If this laboratory work is confirmed in larger studies, it could lead to a role for cholesterol-manipulating drugs in the treatment of glioblastoma, he said.

"Pharmacologic strategies that pump cholesterol out of a cell could lead to significant tumor cell death," said Mischel.

Glioblastoma is currently one of the most lethal cancers. With median survival times of 12 to 15 months, it is often resistant to even the most aggressive chemotherapy and radiotherapy.

"New treatments are needed," he said. "This study uncovers a novel and potentially therapeutically targetable tumor cell growth and survival pathway,
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeting cholesterol to fight deadly brain cancers
2. Targeting innate immunity in malaria
3. Targeting PTEN may prevent skin cancer
4. Targeting the Ewing sarcoma family of tumors
5. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
6. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
7. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
8. Targeting top 911 callers can trim cost, improve patient care
9. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
10. New program targeting whole-person health care gets major grant
11. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... May 29, 2015 The science of ... last decade. New and more efficient methods of FUE hair ... balding patients. One of the most cutting edge hair transplant ... Restoration is the technique of extracting hair from the beard ... are performed to correct male pattern baldness. Beard ...
(Date:5/29/2015)... 29, 2015 According to a recent HealthDay ... full-time workers has a substance abuse problem - the data, ... 111,500 adults with full-time jobs, revealed that 9.5% of those ... year. (1) The National Council on Alcoholism and Drug Dependence ... and an estimated 70% of the 14.8 million illicit drug ...
(Date:5/29/2015)... Cary, North Carolina (PRWEB) May 29, 2015 ... McCann confirmed that the newest Red Hot & Blue restaurant ... for business on Thursday, May 7, 2015. “The Red Hot ... shopping center for 18 years, but we have moved to ... “We are now in the middle of all the activities ...
(Date:5/29/2015)... To compile the list, the Becker's Hospital ... several awards for clinical and general excellence. The team ... to them in terms of overall excellence, and those ... 50 Great Health Systems to Know 2015 list includes ... Fla.) , Advocate Health Care (Downers Grove, Ill.) , ...
(Date:5/29/2015)... May 29, 2015 The Healthcare ... graduates of its Advanced Training Program (ATP) in ... fill roles in their health care organization ranging ... and methodology of continuous quality improvement in the ... to Dr. Brent James’ internationally recognized Advanced Training ...
Breaking Medicine News(10 mins):Health News:Beard to Scalp Hair Transplant: Newest Advance in Hair Transplant Technology 2Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 2Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 3Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 4Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 2Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 3Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 4Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:HORNE LLP’s Healthcare Delivery Institute Graduates Class from the Advanced Training Program 2
... certain factors that seem to increase risk, , , MONDAY, Jan. ... way to better calculate the risk a woman with cancer ... breast. , The chances of developing cancer in a second ... has been found in one breast. And certain factors, such ...
... boost protection from severe respiratory illnesses such as influenza and ... (UNSW) has found, but convincing a reluctant public and health ... trial of the efficacy of masks, researchers found adult mask ... non-wearers to be protected against respiratory viruses, including the common ...
... 26 Mr Yohei Sasakawa, WHO Goodwill Ambassador for ... for the Human Rights of People Affected by Leprosy, ... of the word "leper."Speaking at the launch in London ... Discrimination Against People Affected by Leprosy, held to coincide ...
... support the LIVESTRONG(TM) Global Cancer Summit to take place ... Lance Armstrong Foundation (LAF), a leading nonprofit organization providing ... today that it has selected Ogilvy Public Relations Worldwide ... fight against cancer. Ogilvy PR will work with ...
... Authentidate Holding Corp. (Nasdaq: ADAT ), ... and workflow management services, announced today that it ... and Parascript Management, Inc. (collectively "Parascript") that Parascript ... it entered into with Authentidate. The merger agreement, ...
... Doctors at the,Northwoods Cancer Center near Houston, Texas ... technology from Varian Medical Systems,(NYSE: VAR ... prostate cancer, is,among the first patients in Houston ... which delivers image-guided intensity-modulated radiation therapy,(IMRT) two to ...
Cached Medicine News:Health News:Unmasked and vulnerable 2Health News:Stop Use of Word 'Leper' 2Health News:Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign 2Health News:Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign 3Health News:Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign 4Health News:Authentidate Announces Termination of Merger Agreement With Parascript, LLC 2Health News:Authentidate Announces Termination of Merger Agreement With Parascript, LLC 3Health News:A Fast, New Cancer Fighting Tool Is Now Available in the Houston Area: RapidArc(TM) Radiotherapy Technology from Varian Medical Systems 2Health News:A Fast, New Cancer Fighting Tool Is Now Available in the Houston Area: RapidArc(TM) Radiotherapy Technology from Varian Medical Systems 3
(Date:5/29/2015)... , May 28, 2015 Research and Markets ... "North America MRI Market - Growth, Trends And ... The North American MRI systems market is ... 2014 to $1.58 billion by 2020 with a CAGR ... of three types namely, the open system, closed system ...
(Date:5/29/2015)... 2015 A six-hour certification program on "How ... the Cannabis World Congress & Business Exposition (CWCBExpo) ... .  Taking place on Wednesday, June 17 th ... at the leading event on the East Coast for the ... Clover Leaf University, the first cannabis university to be approved, ...
(Date:5/29/2015)... , May 28, 2015 Research and Markets ... "North America Open System MRI Market - Growth, ... their offering. The key players in the ... Healthcare, Siemens Healthcare and Toshiba Medical Systems ... is replacing CT because of its higher sensitivity and ...
Breaking Medicine Technology:North America MRI Market - Growth, Trends And Forecasts 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare & Toshiba Medical Systems Dominating 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4North America Open System MRI Market 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare and Toshiba Medical Dominating 2
... Tunnell Consulting, Inc. announced today that ... Informatics, an integrated services and technology company based in ... sciences industry consultancy, and Campbell, a provider of data-driven ... is designed to enable both companies to serve their ...
... Biolabs (NEB) has announced that it has received ... fund the research and development of novel enzymatic ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090921/NE79207LOGO-b) New England ... epigenetics research and discovery, and offers a growing ...
Cached Medicine Technology:Tunnell Consulting Forms Strategic Alliance With Ireland-Based Campbell Informatics 2New England Biolabs Receives Award to Develop Novel Enzymatic Reagents for Epigenetic Studies 2
... self-adjusting adaptability to fit almost every operating ... angling at the sit of fixation to ... it to be titled to any position ... a simple adjustment of the 3/D Swinger ...
Inquire...
Stainless steel construction to withstand sterilization modalities (EtO, Steris, and Sterrad)...
Stainless steel construction to withstand sterilization modalities (EtO, Steris, and Sterrad) Wide angle of view...
Medicine Products: