Navigation Links
Targeting cholesterol may help slow glioblastoma
Date:9/15/2011

PHILADELPHIA Glioblastoma is among the most lethal cancers, but scientists have uncovered a novel growth mechanism that suggests patients with glioblastoma could be treated with cholesterol-lowering agents, according to a study published in Cancer Discovery, the newest journal of the American Association for Cancer Research.

Lead researcher Paul Mischel, M.D., Lya and Harrison Latta professor of pathology and laboratory medicine, and professor of molecular and medical pharmacology at the David Geffen School of Medicine at the University of California, Los Angeles, said the study revealed that EGFR vIII, a known oncogene in glioblastoma, increased the activity of the LDL receptor and, therefore, allowed for large amounts of cholesterol.

"Our data demonstrate that glioblastoma cells need large amounts of cholesterol to grow and to survive. This is not surprising considering the critical role of cholesterol in making new membranes, of which rapidly growing tumors need a lot," said Mischel.

Mischel's work is part of a growing body of cancer research where scientists study how they can combat a tumor's growth supply, rather than the tumor itself. The most familiar agents in this arena are the vascular endothelial growth factor inhibitors, like bevacizumab, which restrict a tumor's blood supply.

If this laboratory work is confirmed in larger studies, it could lead to a role for cholesterol-manipulating drugs in the treatment of glioblastoma, he said.

"Pharmacologic strategies that pump cholesterol out of a cell could lead to significant tumor cell death," said Mischel.

Glioblastoma is currently one of the most lethal cancers. With median survival times of 12 to 15 months, it is often resistant to even the most aggressive chemotherapy and radiotherapy.

"New treatments are needed," he said. "This study uncovers a novel and potentially therapeutically targetable tumor cell growth and survival pathway, which could potentially lead to more effective treatments for patients in the clinic."


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Targeting cholesterol to fight deadly brain cancers
2. Targeting innate immunity in malaria
3. Targeting PTEN may prevent skin cancer
4. Targeting the Ewing sarcoma family of tumors
5. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
6. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
7. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
8. Targeting top 911 callers can trim cost, improve patient care
9. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
10. New program targeting whole-person health care gets major grant
11. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... Healthcare is in ... Botelho advocates for the mass media launching of story movements to highlight what's ... share their unfortunate experiences; such a movement can generate the network power to ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Dan Carlisle ... in Jefferson County, is announcing the launch of a charity drive to raise ... of homeless women and children in Birmingham has grown steadily since the 1980’s, ...
(Date:12/8/2016)... ... 08, 2016 , ... Coffey Agencies, a locally owned and ... in the northern Alabama and Georgia regions, is embarking on a charity drive ... has built a network of support and education facilities to develop and provide ...
(Date:12/7/2016)... ... December 07, 2016 , ... "Today, MHA and mental ... mental health systems reform legislation in more than fifty years. We applaud the ... of our elected officials to improving mental health services and supports in our ...
(Date:12/7/2016)... ... December 07, 2016 , ... Wavelink, an industry ... Control through a new partnership with Splashtop Inc. This remote control for Android ... to help businesses maximize their uptime and productivity. , Wavelink offers powerful enterprise ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... FRANCISCO, Calif. , Dec. 8, 2016 /PRNewswire/ ... technology to develop novel antiviral therapeutics, today announced ... as chief executive officer and a member of ... an incredibly experienced executive with a deep background ... Stephen Quake, D.Phil., founder of Agenovir, co-president of ...
(Date:12/8/2016)...  Haemonetics Corporation (NYSE: HAE ) has released ... innovative software suite designed to help customers drive efficiency in ... NextGen DMS 4 improves core features and introduces innovations aligned ... of plasma collected, enhancing quality and regulatory compliance and leveraging ... ...
(Date:12/8/2016)... 8, 2016 Henry Schein, Inc. (Nasdaq: ... and services to office-based dental, animal health and medical practitioners, ... in Marrodent, one of Poland,s largest ... This transaction was announced on August 30, 2016. ... Poland since 2014, and Marrodent marks the Company,s ...
Breaking Medicine Technology: