Navigation Links
Targeting astrocytes slows disease progression in ALS
Date:2/3/2008

In what the researchers say could be promising news in the quest to find a therapy to slow the progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrigs disease, scientists at the University of California, San Diego (UCSD) School of Medicine have shown that targeting neuronal support cells called astrocytes sharply slows disease progression in mice.

The study, conducted in the laboratory of Don Cleveland, Ph.D., UCSD Professor of Medicine, Neurosciences and Cellular and Molecular Medicine and member of the Ludwig Institute for Cancer Research, will appear in the advance online publication on Nature Neuroscience's website on February 3rd.

Mutant genes that cause ALS are expressed widely, not just in the motor neurons, Cleveland explained. Targeting the partner cells like astrocytes, which live in a synergistic environment with the neuron cells, helps stop the cascade of damage. Therapeutically, this is the big news.

ALS is a progressive disease that attacks the motor neurons, long and complex nerve cells that reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body, which act to control voluntary movement. Degeneration of the motor neurons in ALS leads to progressive loss of muscle control, paralysis and untimely death. Estimated to affect some 30,000 Americans, most people are diagnosed with ALS between the ages of 45 and 65. Typically, ALS patients live only one to five years after initial diagnosis.

In findings published in Science in June 2006, Cleveland and his colleagues showed that in early stages of inherited ALS, small immune cells called microglia are damaged by mutations in the SOD1 protein, and that these immune cells then act to significantly accelerate the degeneration of the motor neurons. The new study demonstrates that much the same thing happens to astrocytes, support cells that are essential to neuronal function, and whose dysfunction is implicated
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Targeting gut bugs could revolutionize future drugs, say researcher
2. New Research Shows Nutrition Programs Targeting Pregnancy and First 24 Months of Life Dramatically Improve Child Survival and Overall Health
3. APIC launches Targeting Zero initiative to eradicate infections deemed preventable by CMS
4. Tobacco marketers targeting teens near schools
5. Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
6. Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
7. Isis Adds New Drug to Its Development Pipeline: ISIS 388626 Targeting SGLT2 for the Treatment of Type 2 Diabetes
8. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
9. Chronic infection persists by targeting stromal cell network in lymphoid organs
10. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
11. Sorafenib Slows Growth of Some Leukemias
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... 2013 On May 25, Voices Against ... and advocacy, comments on a new study by the ... cold atmospheric plasma into brain cancer treatment may help ... a Science Daily article, physicists from the ... physicians demonstrated the “synergistic effect of cold atmospheric plasma ...
(Date:5/25/2013)... 25, 2013 According to world-renowned scholars, ... and powerful women that ever lived. Cleopatra’s legendary beauty ... of the most powerful men in her time. Cleopatra ... to keep her skin glowing and fresh, from her ... wax, maringa oil and cyprus grass. , Cleopatra was ...
(Date:5/25/2013)... Prairie Living at Chautauqua , ... American Red Cross Blood Drive from 1:30 to 5:30 ... is located at 955 Villa Ct. in Carbondale, Illinois, ... Medicaid, who need some help to maintain their independence.. ... Andrea Arview Frey, Director of Marketing for Prairie Living. ...
(Date:5/25/2013)... Superior Magnetics for Pain Free Living announced a ... tendinitis and bursitis , Pain Free Living - SuperiorMagnetics.com ... magnetic bracelet so strong it relieves pain ... demonstrated at fairs and festivals. This new magnetic health ... customers often report pain relief in seconds. , “This ...
(Date:5/25/2013)... The product liability lawyers at Wright ... on behalf of 23 property owners who live throughout the ... April 25, 2013 and names E.I. DuPont De Nemours and ... Schulte Imprelis lawsuits, this case will be litigated in the ... Imprelis lawsuit alleges that, due to the use ...
Breaking Medicine News(10 mins):Health News:Voices Against Brain Cancer Comments on Study that Shows Cold Plasma’s Success Against Brain Cancer Cells 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 3Health News:Carbondale Affordable Assisted Living Community to Host Red Cross Blood Drive 2Health News:Magnetic bracelet relieves pain in seconds announces Superior Magnetics 2Health News:Imprelis Lawsuit Filed on Behalf of Multiple Property Owners Nationwide Who Allege Imprelis Use Resulted In Extensive Tree Damage and Death, Reports Wright & Schulte 2Health News:Imprelis Lawsuit Filed on Behalf of Multiple Property Owners Nationwide Who Allege Imprelis Use Resulted In Extensive Tree Damage and Death, Reports Wright & Schulte 3Health News:Imprelis Lawsuit Filed on Behalf of Multiple Property Owners Nationwide Who Allege Imprelis Use Resulted In Extensive Tree Damage and Death, Reports Wright & Schulte 4
... Force Operations Lead to Indictment of 30 Individuals Charged in ... Fraudulent Billing to Medicare , WASHINGTON, Dec. 15 ... their alleged roles in schemes to submit more than $61 ... operation of the Medicare Fraud Strike Force, Department of Health ...
... ... United Nations Foundation has led the fight against malaria, and I am encouraged ... malaria deaths are working,” said Dr. Daniel Carucci, Vice President for Global Health for the ... Washington, ...
... ... opportunity for the unemployed or those needing additional income... known as one of the simplest ... ... nation,s most successful collection agencies, is spreading holiday cheer and good will that is going ...
... as accurate a surgical method, with fewer complications, analysis ... it comes to diagnosing breast cancer, women and their ... the less invasive "core needle biopsy" procedure is nearly ... surgical procedure is, with fewer complications than the surgical ...
... ... today. As competitors come together to expand their reach globally or complete ... of safety programs. , A new free, white paper from Howard Leight ... details how the merger between US Airways and America West led the ...
... , , STAMFORD, Conn., Dec. 15 ... Corporation (NYSE: AON ), today announced Lisa Zeitel has ... Benefits Practice and member of the national Pharmacy Practice. , ... will work under the direction of Aon Consulting,s Pharmacy Practice Director ...
Cached Medicine News:Health News:Medicare Fraud Strike Force Expands Operations Into Brooklyn, N.Y.; Tampa, Fla.; and Baton Rouge, La. 2Health News:Medicare Fraud Strike Force Expands Operations Into Brooklyn, N.Y.; Tampa, Fla.; and Baton Rouge, La. 3Health News:Medicare Fraud Strike Force Expands Operations Into Brooklyn, N.Y.; Tampa, Fla.; and Baton Rouge, La. 4Health News:Medicare Fraud Strike Force Expands Operations Into Brooklyn, N.Y.; Tampa, Fla.; and Baton Rouge, La. 5Health News:Statement by Dr. Daniel Carucci, Vice President for Global Health for the United Nations Foundation, on Progress Shown in World Malaria Report 2009 2Health News:RPS Worldwide Launches Affiliate Program -- The Collection Agency That Gives Christmas Back, Rather Than Take it Away 2Health News:RPS Worldwide Launches Affiliate Program -- The Collection Agency That Gives Christmas Back, Rather Than Take it Away 3Health News:Needle Biopsy Works Well in Diagnosing Breast Cancer 2Health News:New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways 2Health News:New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways 3Health News:New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways 4Health News:Aon Consulting Adds Senior Vice President to National Pharmacy Practice 2Health News:Aon Consulting Adds Senior Vice President to National Pharmacy Practice 3Health News:Aon Consulting Adds Senior Vice President to National Pharmacy Practice 4
(Date:5/24/2013)... 24, 2013 In accordance with Rule 17.1 and ... of the United States Exchange Act, Echo Pharma Acquisition Limited ... Elan Corporation (NYSE: ELN). Background On ... an offer for the entire of the issued and to ... "Original Offer").  On 20 May 2013, Royalty ...
(Date:5/23/2013)... May 23, 2013  Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... named the 2013 Life Science Firm of the Year by ... Vanda was honored at the TCM,s 25 th Annual ... Maryland.  The Tech Awards Celebration recognizes the leaders and innovators ... Maryland and the surrounding regions. ...
(Date:5/23/2013)... Nephros, Inc. (OTC Bulletin Board: ... develops and sells high performance liquid purification ultrafilters, announced ... addition, the concurrent temporary reduction in exercise price for ... 2013. Nephros estimates that it will receive ... A portion of the proceeds will be used for ...
Breaking Medicine Technology:Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 9Vanda Pharmaceuticals Named the 2013 Life Science Firm of the Year by the Tech Council of Maryland 2Nephros Announces Completion of Rights Offering 2Nephros Announces Completion of Rights Offering 3Nephros Announces Completion of Rights Offering 4
... Orbitz Worldwide, Inc. (NYSE: OWW ) will host a conference call to ... on Wednesday, May 5, 2010 at 10:00 a.m. EDT ( 9:00 ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20070813/AQM125LOGO ) , ... A live webcast of the call can be accessed through the Orbitz Worldwide ...
... April 26 Jazz Pharmaceuticals, Inc. (Nasdaq: JAZZ ) announced ... will present at Deutsche Bank,s 35th Annual Health Care Conference on Monday, ... InterContinental Boston Hotel in Boston, MA. , ... A live webcast of the presentation may be accessed from the ...
Cached Medicine Technology:Orbitz Worldwide, Inc. to Host First Quarter 2010 Earnings Call on May 5 2Orbitz Worldwide, Inc. to Host First Quarter 2010 Earnings Call on May 5 3
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Medicine Products: