Navigation Links
Targeting aggressive breast cancers by putting them to sleep
Date:3/25/2008

It is well established that Id1, a gene normally produced only in embryonic development, is reactivated in many 'solid' cancers, or carcinomas.

In the case of breast cancer, the Id1 gene is active only in the more aggressive and metastatic varieties of cancer. Typically those cancers do not possess the oestrogen receptor, and for that reason cannot be treated with Tamoxifen (a drug that interferes with the action of oestrogen), the most effective breast cancer treatment available.

The outcomes for women with breast cancers producing Id1 are therefore much worse than for women with other forms of breast cancer.

Findings by Dr Alex Swarbrick, a scientist at Sydney's Garvan Institute of Medical Research, in collaboration with Professor J. Michael Bishop, Nobel Prize winner and Chancellor of the University of California San Francisco (UCSF), may provide hope for such women in the future. Their article, published online this week in the international journal Proceedings of the National Academy of Sciences, USA (PNAS), shows that Id1 drives some breast cancers.

Dr Swarbrick initiated the Id1 project three years ago while working as a post doctoral researcher in the laboratory of Professor Bishop He conducted much of the experimental work for the project at UCSF, then analysed the data and tissue samples at Garvan. "We happened to ask the right questions about the right gene," he said. "Up to that point, no-one else had asked whether or not Id1 actually contributed to the origin and behaviour of breast cancer".

"By artificially activating the Id1 protein in mouse mammary glands, we demonstrated that Id1 indeed contributes to cancer - and that mammary cancers with high levels of Id1 become very aggressive and highly metastatic."

"We also showed that if we genetically switch off the Id1 gene in an established tumour, those mice live much longer than mice with continual Id1 expression in their tumour. In fact about 4
'/>"/>

Contact: Alison Heather
A.heather@garvan.org.au
61-292-958-128
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Chronic infection persists by targeting stromal cell network in lymphoid organs
3. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
4. Isis Adds New Drug to Its Development Pipeline: ISIS 388626 Targeting SGLT2 for the Treatment of Type 2 Diabetes
5. Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
6. Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
7. Tobacco marketers targeting teens near schools
8. APIC launches Targeting Zero initiative to eradicate infections deemed preventable by CMS
9. New Research Shows Nutrition Programs Targeting Pregnancy and First 24 Months of Life Dramatically Improve Child Survival and Overall Health
10. Targeting gut bugs could revolutionize future drugs, say researcher
11. Targeting astrocytes slows disease progression in ALS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... 2015 The IRS released an ... that, “criminals used taxpayer-specific data acquired from non-IRS sources ... tax accounts through IRS’ “Get Transcript” application. This data ... address.” , “You don’t even have to be ... it was only a matter of time, especially after ...
(Date:5/29/2015)... May 30, 2015 “In the ... local and federal regulations, we provide education that ... patients who are suffering from pain, within the ... Nalamachu, MD, professor of rehabilitation medicine and President/Medical ... Overland Park, Kansas. , A new flight of ...
(Date:5/29/2015)... Tallahassee, FL (PRWEB) May 29, 2015 Ready ... trip, it’s important for all drivers to get their vehicles ... do to be prepared. Advanced Driving Systems (ADS) is ready ... some tips on preparing for summer road trips. , When ... do the following to ensure that the trip goes smoothly ...
(Date:5/29/2015)... May 29, 2015 The science of ... Los Angeles thanks to the efforts of internationally recognized ... has combined ARTAS hair restoration and manual ... restoration procedures available anywhere. , A Follicular Unit ... individually harvesting hair follicle grafts from the donor areas ...
(Date:5/29/2015)... Island (PRWEB) May 29, 2015 The ... 2015. The event, now closed to new registration, starts ... Adams. This exciting competitive running event demonstrates the ... to create a public benefit – in this case, ... coastal views around the famed Ocean Drive and passes ...
Breaking Medicine News(10 mins):Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 2Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 3Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 4Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 5Health News:PAINWeekEnd Kansas City: Pain Management CME for the Main Street Practitioner 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 3Health News:Los Angeles and Beverly Hills Hair Transplant Doctor Now Combines Robotic Hair Restoration (ARTAS) and Manual FUE Transplants for Maximum Hair Coverage 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 3
... of the communicable diseases in the country, according to ... Health and Family Welfare//. The news report was released ... a village near Vriddachalam. Chidambaram MP, E Ponnusamy, MLAs ... function. ,As many as 60 government doctors, ...
... UNICEF would collaborate on spreading awareness regarding the transmission ... spreading awareness to young people the dangers of HIV ... as children’s and young people are more attracted towards ... Understanding was signed in Delhi in the presence of ...
... is an idiopathic inflammatory disorder of the ... remain incompletely understood, many experimental and clinical ... in its pathogenesis//. ,In genetically ... failure of normal regulatory constraints on the ...
... of Delaware have developed a unique nanobomb that can ... more specifically breast cancer cells//. ,This latest attack ... and Oncology Issues by Balaji Panchapakesan, assistant professor of ... that the nanobomb technology is still in its infancy ...
... Immunodeficiency Virus type 1 (HIV-1) infection has improved ... 1996//. More recently, new drugs have been approved, ... while some previously popular drugs are being used ... Resistance testing is used more commonly in clinical ...
... have found an active gene in the legs of fleas, ... the flea to jump and leap at incredible heights and ... an incredible speed of 200 times/second. , ,Scientists have ... cultured them in the bacteria E.coli and found that it ...
Cached Medicine News:Health News:Non-Communicable Diseases Mounting Up At An Alarming Rate in India 2Health News:Indian Olympic Association And UNICEF To Collaborate On HIV/AIDS Awareness 2Health News:Bifidogenic Growth Stimulator: A Non-Toxic Way To Treat Ulcerative Colitis 2Health News:Simplest therapeutic regimen found less effective against HIV 2Health News:Resilin Protein from Flea can be used for cardiovascular disease 2
(Date:5/28/2015)... , May 28, 2015 Zimmer Holdings, Inc. ... has finalized agreements with buyers to divest in ... High-Flex Knee System assets, Biomet Discovery® Elbow System assets ... in furtherance of Zimmer,s pending acquisition of Biomet, Inc. ... continues to work constructively with the Bureau of Competition ...
(Date:5/28/2015)... , May 28, 2015 ... has announced the addition of Jain PharmaBiotech,s ... Companies"  to their offering.  ... (RNAi) or gene silencing involves the use ... the cell, this material is processed into ...
(Date:5/28/2015)... May 28, 2015  IRIDEX Corporation (NASDAQ: IRIX ) ... James H. Mackaness is scheduled to present at ... 9:00 am PT in Los Angeles . ... be accessed on the Event Calendar of the Investors section ... the webcast will be available shortly after the conclusion of ...
Breaking Medicine Technology:Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 3Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 4Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 6Global RNAi Market Report 2015-2024 - Technologies, Markets and Companies 2Global RNAi Market Report 2015-2024 - Technologies, Markets and Companies 3
... The U.S. Food and Drug Administration today approved a medical ... failure to help keep them alive until a donor for ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) The mechanical pulsatile cardiac assist ... German company, Berlin Heart. The device comes in graduated sizes ...
... brand websites fulfill a pivotal role in educating ... for critical healthcare decisions. Superior brand websites deliver ... tools afforded by the Internet, such as online ... signature support incentives, and access to experts. ...
Cached Medicine Technology:FDA Approves Mechanical Cardiac Assist Device for Children With Heart Failure 2FDA Approves Mechanical Cardiac Assist Device for Children With Heart Failure 3Pharmaceutical Brand Websites Need Effective Online Tools to Deliver Full Spectrum of Patient Support 2
Inquire...
The Perfect Single basic Vac Manifold is used to process a single 96-well plate; processing time is approximately 30 minutes....
The Perfect Vac Quad Manifold allows one to four 96-well plates to be processed simultaneously. A single plate may be processed in 30 minutes; four plates are processed in 45 minutes....
... from Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen Blow-Down Evaporators. For over ten ... today. ... ... ...
Medicine Products: