Navigation Links
Targeting PTEN may prevent skin cancer
Date:7/26/2011

PHILADELPHIA Scientists believe they have identified a role for PTEN, a known tumor suppressor, in removing DNA damage derived from UVB radiation, a known risk factor for non-melanoma skin cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

Yu-Ying He, Ph.D., an assistant professor of medicine at the University of Chicago, found that laboratory mice with reduced levels of PTEN were more likely to have UVB-induced skin cancers.

"This was an unexpected finding and definitely provides a new approach for chemoprevention strategies," she said. "It's possible that if we can increase PTEN activity through nutritional supplements or some sort of pharmaceutical intervention, we may be able to prevent this common cancer."

Non-melanoma skin cancer is the most common cancer in the United States. The 1 million cases diagnosed last year accounted for 40 percent of all new diagnosed cancers. Scientists know that the major risk factor for this type of skin cancer is UVB radiation from sunlight, which leads to DNA damage.

PTEN, which was first identified in 1997, promotes genomic stability and cellular repair and can lead to a reduction in the molecular misfiring that leads to cancer and tumor progression.

In the current study, He and colleagues exposed skin cells to UVB radiation and examined the rates of DNA repair. Those with lower PTEN levels had slower rates of DNA repair, because of loss of the key DNA repair protein xeroderma pigmentosum C (XPC). Importantly, if the scientists restored the levels of XPC, then the rates of DNA repair went up as well.

"Cells without appropriate levels of PTEN were not able to repair sufficiently," said He.

He called the idea of a chemoprevention trial "promising," and said that her lab plans to assess the chemopreventive potential of restoring PTEN function.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Targeting the Ewing sarcoma family of tumors
2. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
3. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
4. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
5. Targeting top 911 callers can trim cost, improve patient care
6. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
7. New program targeting whole-person health care gets major grant
8. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
9. Scientists announce new advance with potential for future cancer targeting
10. Investment in CRC screening targeting pre-medicare population could cut medicare treatment costs
11. Targeting hit-and-run cancer viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... ... Association’s Outstanding Public Communication of Education Research Award. The award honors scholars exemplary ... communities. It recognizes a scholar who has demonstrated the capacity to deepen the ...
(Date:4/24/2017)... ... 2017 , ... Veteran Theresa James awoke to the sound of her newly ... “Healing Tears,” James depicts every parent’s worst nightmare, when her three children were violently ... and situations throughout my divorce,” James said. “After the death of my children, I ...
(Date:4/24/2017)... Waycross, Ga. (PRWEB) , ... April 24, 2017 ... ... and trusted advisor within the telehealth industry, announces the company’s VideoMedicine mobile platform ... primary care providers. Available 24 hours a day, Quick Care provides patients with ...
(Date:4/24/2017)... ... 2017 , ... Rod Burkett, CEO of Gardant Management Solutions, was recently featured ... at the forefront of Gardant since it was founded in 1999. His drive and ... of more than 40 new senior living communities. With his leadership, Gardant has grown ...
(Date:4/24/2017)... ... April 24, 2017 , ... Donna Parker, L. Ac. reads all ... found any of them to be very practical. She wanted to write a guide/workbook ... changes in their health. It prompted her in writing “ A Clear Path to ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 NeuroVive Pharmaceutical ... today announced positive preclinical results demonstrating anti-fibrotic ... for non-alcoholic steatohepatitis (NASH), in an additional ... NV556 has previously shown similar anti-fibrotic ... Today, NeuroVive,s scientists present novel data demonstrating ...
(Date:4/19/2017)... 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), ... Healthcare Investor Conference 2017 at the Sheraton Hotel in ... Executive Officer of the Company is scheduled to present on Tuesday, ... and the Chairman of the Board, Tony Holler ... ...
(Date:4/19/2017)... YORK , April 19, 2017 The Mobile ... to showcase a healthy CAGR during the forecast period ... type in the global digital mobile X-Ray devices market, which ... Mn in 2017, expanding at a CAGR of 7% over ... absolute $ opportunity of more than US$ 100 Mn in ...
Breaking Medicine Technology: