Navigation Links
Targeting Cancer's Own Stem Cells to Fight Recurrence
Date:1/21/2009

In the lab, scientists used a virus to thwart tumor's comeback

WEDNESDAY, Jan. 21 (HealthDay News) -- Scientists have located a group of cancer stem cells or "tumor-initiating cells" which, when targeted with a reprogrammed herpes virus, are prevented from turning malignant.

The finding bolsters the theory that cancer harbors its own secret cache of stem cells that are resistant to conventional therapies and responsible for tumor re-emergence.

Eliminating these malingerers could be key in the fight against certain cancers, such as neuroblastoma, which was the focus of this study.

"This research and this line of research in general is very exciting," added Dr. L. Gerard Toussaint III, an assistant professor of neuroscience and experimental therapeutics at Texas A&M Health Science Center College of Medicine and a neurosurgeon with the Texas Brain and Spine Institute in Bryan. "Their approach is to genetically engineer a virus that would only be turned on in the stem cell population."

This type of virus-against-cancer therapy may be the next generation of anti-cancer treatments, he said.

The study was published online Jan. 21 in the journal PLoS (Public Library of Science) One.

Neuroblastomas, which develop in the nerve tissue of the adrenal gland, neck, chest or spinal cord, account for 8 percent to 10 percent of childhood cancers, the report stated. Remission is common, but so is relapse, and long-term survival in high-risk cases is less than 50 percent.

"The cancer often responds to chemotherapy and more often than not will shrink but too often it comes back," explained Dr. Jeffrey Toretsky, an associate professor of oncology and pediatrics at Georgetown's Lombardi Comprehensive Cancer Center in Washington, D.C. "The promise is that they will be able to successfully create some agent, a virus, that would be able to get at the cells responsible for regrowth."


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Chronic infection persists by targeting stromal cell network in lymphoid organs
3. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
4. Isis Adds New Drug to Its Development Pipeline: ISIS 388626 Targeting SGLT2 for the Treatment of Type 2 Diabetes
5. Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
6. Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
7. Tobacco marketers targeting teens near schools
8. APIC launches Targeting Zero initiative to eradicate infections deemed preventable by CMS
9. New Research Shows Nutrition Programs Targeting Pregnancy and First 24 Months of Life Dramatically Improve Child Survival and Overall Health
10. Targeting gut bugs could revolutionize future drugs, say researcher
11. Targeting astrocytes slows disease progression in ALS
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Targeting Cancer's Own Stem Cells to Fight Recurrence
(Date:9/18/2014)... York, New York (PRWEB) September 18, 2014 ... Xarelto lawsuits ( http://www.xareltolawsuitcenter.com ) currently pending in ... to have all claims filed on behalf of ... to motions filed on September 11th, the defendants ... other claims contained in the lawsuits have no ...
(Date:9/18/2014)... Memorial Cardiac and Vascular Institute ... performing the first ever, adult heart transplant in Broward ... Sharing) approval to launch the adult heart transplant program ... in South Florida. , The skilled cardiac transplant ... Medical Director of the Adult Heart Transplant and Mechanical ...
(Date:9/18/2014)... 18, 2014 (HealthDay News) -- Older people become more ... because the balance of stress hormones during bereavement changes ... people who are grieving are more likely to have ... "During the difficult weeks and months after loss, ... the most abundant type of white blood cell and ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 One of ... air medical transport industry, ShandsCair Flight Program’s ... Helicopters Inc . (AHI) at the Air Medical Transport ... recently delivered and placed into service ShandsCair EC155 and ... will be displayed at AMTC highlight Airbus Helicopters broad, ...
(Date:9/18/2014)... (HealthDay News) -- Daily supplements of selenium or vitamin ... of age-related cataracts among men, a new study indicates. ... both could help prevent cataracts. To investigate this further, ... Medical School in Boston, and his colleagues examined data ... E. The trial was initially designed to study prevention ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 3Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 2Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 3Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 4Health News:Grief Can Weigh on Immune System in Older Folks, Study Says 2Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 2Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 3Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 4Health News:Vitamin E, Selenium Supplements Don't Seem to Prevent Cataracts 2
... new study researchers say they found that chest pain ... elderly patients treated // with angioplasty and those on ... these benefits earlier. ,Patients treated with surgery ... treated patients required more antianginal drugs throughout the study. ...
... most common symptom in patients with plaque build-up in ... medication // nifedipine (Adalat or Procardia) may be safe ... angina symptoms and prolongs heart-problem-and-procedure-free survival. ,For ... nifedipine gastrointestinal therapeutic system or a placebo. GITS modifies ...
... solvents and cleaning products at home may increase the ... findings from a recent study. Researchers found the levels ... the homes of children with asthma. Volatile organic compounds ... polishes, room fresheners, fitted carpets, and cigarette smoke. ...
... Researchers from the University of Florida College of Medicine ... for hypertension // in older patients. Researchers say most ... blood pressure, so this study was set up to ... study found patients had similar outcomes when they took ...
... frustrated when patients ask them what type of bed is ... done// on this issue to support their answers. Therefore, researchers ... a firm vs. a medium-firm mattress when it comes to ... had their own bed mattresses replaced with either a firm ...
... degenerative joint disease and one of the oldest and ... joint’s cartilage breaks down and the bones rub against ... ,An international, multi-center study shows an effective treatment for ... Prexige. The drug was found to reduces gastric complications ...
Cached Medicine News:
(Date:9/18/2014)... ANN ARBOR, Mich. , Sept. 18, 2014 /PRNewswire-USNewswire/ ... Medical Research will allow the University of Michigan to ... The Glenn Center for Aging Research ... growing evidence that drugs can slow the effects of ... to unlock mechanisms of aging that can help develop ...
(Date:9/18/2014)... , Sept. 18, 2014   3D Systems   ... the Simbionix RobotiX Mentor™ , a new robotic surgery ... the first time at the ERUS exhibition in ... (booth #7). Robotic-assisted minimally invasive surgery represents a ... means the needs for training for robotic surgery has increased, ...
(Date:9/18/2014)... , Sept. 18, 2014  Halozyme Therapeutics, Inc. ... the U.S. Food and Drug Administration (FDA) has ... dosing of PEGPH20 in SWOG,s ongoing Phase 1b/2 ... evaluate Halozyme,s investigational drug PEGPH20 (PEGylated Recombinant Human ... in patients with metastatic pancreatic adenocarcinoma.  The study ...
Breaking Medicine Technology:$3 M grant funds Paul F. Glenn Center for Aging Research at the University of Michigan 2$3 M grant funds Paul F. Glenn Center for Aging Research at the University of Michigan 33D Systems Introduces New Simbionix Robotics Training Platform 23D Systems Introduces New Simbionix Robotics Training Platform 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 2SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: