Navigation Links
Targeting Cancer's Own Stem Cells to Fight Recurrence
Date:1/21/2009

In the lab, scientists used a virus to thwart tumor's comeback

WEDNESDAY, Jan. 21 (HealthDay News) -- Scientists have located a group of cancer stem cells or "tumor-initiating cells" which, when targeted with a reprogrammed herpes virus, are prevented from turning malignant.

The finding bolsters the theory that cancer harbors its own secret cache of stem cells that are resistant to conventional therapies and responsible for tumor re-emergence.

Eliminating these malingerers could be key in the fight against certain cancers, such as neuroblastoma, which was the focus of this study.

"This research and this line of research in general is very exciting," added Dr. L. Gerard Toussaint III, an assistant professor of neuroscience and experimental therapeutics at Texas A&M Health Science Center College of Medicine and a neurosurgeon with the Texas Brain and Spine Institute in Bryan. "Their approach is to genetically engineer a virus that would only be turned on in the stem cell population."

This type of virus-against-cancer therapy may be the next generation of anti-cancer treatments, he said.

The study was published online Jan. 21 in the journal PLoS (Public Library of Science) One.

Neuroblastomas, which develop in the nerve tissue of the adrenal gland, neck, chest or spinal cord, account for 8 percent to 10 percent of childhood cancers, the report stated. Remission is common, but so is relapse, and long-term survival in high-risk cases is less than 50 percent.

"The cancer often responds to chemotherapy and more often than not will shrink but too often it comes back," explained Dr. Jeffrey Toretsky, an associate professor of oncology and pediatrics at Georgetown's Lombardi Comprehensive Cancer Center in Washington, D.C. "The promise is that they will be able to successfully create some agent, a virus, that would be able to get at the cells responsible for regrowth."

Experts have theorized that stubborn and apparently undetectable stem cells are left unscathed by existing treatments, linger in the body and eventually reform the tumor or cause the cancer to spread.

"They go into remission then we don't detect the disease at all for one, two, three years, and then it comes back," explained study senior author Dr. Timothy Cripe, professor of pediatrics at Cincinnati Children's Hospital Medical Center and the University of Cincinnati. "Stem cells would explain that. We need to understand those cells and target them."

"If cancers are being seeded by a few cells, they need to be the target. We have maxed-out therapy for cancers, in particular neuroblastoma. We need to identify something novel and different," he continued.

These researchers identified and then grew several lines of human neuroblastoma cells that seemed to have characteristics of neural stem cells -- meaning, among other things, that they could grow into different types of cells including tumors. The cells also carried the protein nestin, which is a marker for nerve stem cells and is also present in neuroblastoma cells.

When the stem cells were infected with a herpes simplex virus which specifically targets nestin, they did not form tumors over the next 60-day period. When infected with a different virus that does not target nestin, mice developed tumors within 40 days. Mice who were uninfected with either virus developed tumors within 30 days.

But, Cripe cautioned, "we used cell lines propagated in plastic dishes. [We need to know] how does that relate to cells in humans?"

More information

There's more on neuroblastomas at the U.S. National Cancer Institute.



SOURCES: Timothy Cripe, M.D., professor, pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati; L. Gerard Toussaint III, M.D., assistant professor, neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine and neurosurgeon, Texas Brain and Spine Institute, Bryan; Jeffrey Toretsky, M.D., associate professor, oncology and pediatrics, Georgetown's Lombardi Comprehensive Cancer Center, Washington, D.C.; Jan. 21, 2009, PLoS (Public Library of Science), online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Chronic infection persists by targeting stromal cell network in lymphoid organs
3. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
4. Isis Adds New Drug to Its Development Pipeline: ISIS 388626 Targeting SGLT2 for the Treatment of Type 2 Diabetes
5. Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
6. Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
7. Tobacco marketers targeting teens near schools
8. APIC launches Targeting Zero initiative to eradicate infections deemed preventable by CMS
9. New Research Shows Nutrition Programs Targeting Pregnancy and First 24 Months of Life Dramatically Improve Child Survival and Overall Health
10. Targeting gut bugs could revolutionize future drugs, say researcher
11. Targeting astrocytes slows disease progression in ALS
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Targeting Cancer's Own Stem Cells to Fight Recurrence
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: