Navigation Links
Targeted toxin active in platinum-resistant ovarian cancers
Date:4/6/2013

WASHINGTON -- A new antibody-guided drug has shown promising activity in a phase I trial involving ovarian cancer patients with platinum drug-resistant disease, researchers from Dana-Farber Cancer Institute will report today at the annual meeting of the American Association for Cancer Research. The findings (abstract LB-290) will be discussed at a press conference on Saturday, April 06, 2013, 1:00 p.m., ET, in Room 153, in the Washington Convention Center and later at an oral presentation on Tuesday, April 09, 2013, 4:00 p.m. to 4:20 p.m. in room 146, in the Washington Convention Center.

Joyce Liu, MD, MPH, first author of the study, said that among 29 patients who received the antibody-drug conjugate at what was found to be the maximum tolerated dose, there was one complete response and four partial responses. "In addition, there were additional patients with prolonged stable disease who were able to stay on treatment," said Liu, of the gynecologic oncology treatment center at Dana-Farber.

The responses all occurred in patients whose tumors had high expression of the MUC16 protein to which the drug is targeted. Known as DMUC5754A, the drug conjugate consists of an antibody, which recognizes the MUC16 protein expressed by ovarian cancer cells, fused to a toxin, MMAE, which prevents cancer cells from dividing. Targeting the drug conjugate specifically to ovarian cancer cells reduced adverse effects of the toxin on healthy tissues and organs, said Liu. She called the safety profile "encouraging." Most common adverse effects were fatigue, nausea, and vomiting. This phase 1 multicenter trial is the first use in humans of DMUC5754A, and the responses, which Liu called "a nice sign of activity in a very challenging type of ovarian cancer to treat," merit further testing in a phase II trial, which is being planned. "If the activity of this drug is confirmed in additional trials, this will represent a novel type of therapy for ovarian cancer," Liu said.


'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. The future of personalized and targeted cancer therapy
2. Medicaid Fraud in New York Targeted by New House Report
3. Targeted Equine Nutrition Launches New Website For Horse Lovers
4. Banning food ads targeted at kids
5. Study finds tiny, targeted drug particles may be effective in treating chronic diseases
6. Blood Test Plus Targeted Care May Stop Heart Failure Before It Starts
7. Medical Advertising Agency bryantBROWN Healthcare Introduces Targeted Point-of-Care Promotions to Help Law Firms Connect More Directly With Patients and Caregivers
8. Tuberculosis and neglected diseases targeted by new center
9. Lancet Oncology: Long-term side-effects of targeted therapies in pediatric cancer patients
10. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces Quick Weight Loss for Women of All Ages With Targeted Diet Plan
11. High Complexity Laboratory Testing Supports New Targeted Therapies for Leukemias and Lymphomas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... The ... today, as organizations, advocates, and individuals join together to increase recognition about the ... ultimately save lives. , “Today we mark a nationwide movement to raise awareness ...
(Date:2/22/2017)... ... February 22, 2017 , ... A product of digesting a ... derive a heart-protective benefit from eating soy foods, while others do not, a University ... are able to produce equol—a substance made by some types of “good” gut bacteria ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... Pet obesity ... and 54% of dogs, according to the Association for Pet Obesity Prevention (APOP). During ... key pet food issues such as the benefits of corn and grains, value of ...
(Date:2/22/2017)... ... 22, 2017 , ... In a recent article ... context (age, illness and life choices) should be dissociated from medical errors and ... In addition, all too often, studies regarding health system performance in other countries, ...
(Date:2/21/2017)... , ... February 21, 2017 , ... ... Nation Regional Medical Clinic in Durant, Oklahoma, on Feb. 21. , The celebration ... tours for community members, clinic employees, the construction team and tribal leadership. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb 22, 2017 Research and ... Market Analysis & Trends - Industry Forecast to 2025" report to ... The Global ... around 5.2% over the next decade to reach approximately $2.1 billion by ... and forecasts for all the given segments on global as well as ...
(Date:2/22/2017)... Calif. , Feb. 22, 2017  Applied Silver, the ... Barnes to the company,s advisory board. Ms. Barnes is ... joining business, advertising, engineering, legal, and healthcare experts Scott ... John Goodrich , J. Tress Ritter , and ... BSN, CIC, FAPIC brings more than three decades of nationally ...
(Date:2/22/2017)... 2017 Oncternal Therapeutics, Inc., a clinical-stage ... and common malignancies, today announced the closing of ... intends to use the proceeds to further clinical ... advance preclinical development of a new ROR1-targeted antibody-drug ... first-in-class anti-ROR1 monoclonal antibody being developed to treat ...
Breaking Medicine Technology: