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Targeted therapy promising for HER2-positive metastatic breast cancer
Date:10/8/2010

e rates of clinically relevant adverse events were significantly lower in the T-DM1 arm (37%) compared to the rate in women given traztuzumab plus docetaxel (75%).

This trial is ongoing and the positive outcomes are generating enthusiasm for a larger Phase-III trial which is now underway. "This trial is named MARIANNE, and it evaluates taxane plus trastuzumab against T-DM1 as administered in this study, with a third option being T-DM1 plus pertuzumab, another novel anti-HER2 agent," said Prof Perez. "I feel privileged to continue our collaborative work to help bring new and better therapeutic options for patients."

The results are important for two reasons, commented Dr Fabrice Andr from Institut Gustave Roussy in Villejuif, France.

"Firstly, they confirm that in coming years chemotherapy could be replaced by a less toxic compound. Indeed, in the present study, the rates of serious adverse events were much lower in patients given T-DM1 compared to the chemotherapy arm. These results suggest that, with the same efficacy, T-DM1 could dramatically reduce the toxicities related to chemotherapy."

The second important implication of this study is that it proves the concept that linking a monoclonal antibody to a cytotoxic drug leads to an anticancer effect. "This could have several implications beyond drugs that target HER2," Dr Andr said.


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Contact: Vanessa Pavinato
pavinato.vanessa@esmo.org
39-024-342-3649
European Society for Medical Oncology
Source:Eurekalert

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