Navigation Links
Targeted therapy promising for HER2-positive metastatic breast cancer
Date:10/8/2010

A new type of breast cancer treatment has shown encouraging activity as a first-line therapy in HER2-positive metastatic disease, researchers reported at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy.

Principal investigator Edith Perez, MD, Mayo Clinic in Florida, presented the results of the first ever randomized trial of trastuzumab-DM1 (T-DM1) as a first-line treatment for metastatic breast cancer.

T-DM1 is the first of a new type of cancer medicine known as an antibody-drug conjugate. It binds together two existing cancer drugs with the aim of delivering both drugs specifically to cancer cells: trastuzumab, a monoclonal antibody that targets cells that overproduce the protein HER2; and DM1, a chemotherapy agent that targets microtubules.

"This is the first ever presentation of an anti-HER2 antibody-drug conjugate used as first-line therapy for patients with advanced breast cancer," said Professor Perez. "We are encouraged by the results. The study demonstrated that T-DM1 has very good anti-tumor activity as well as much lower toxicity when evaluated side by side to the older 'standard'."

T-DM1 has shown promising activity in preclinical studies. Other clinical trials have also shown it to be effective in patients whose advanced cancer has not responded to other treatments. "This trial represents the logical step --moving the drug up to patients with newly diagnosed HER2-positive metastases," Prof Perez said.

In the trial, researchers randomly assigned 137 women to treatment with either trastuzumab plus the chemotherapy drug docetaxel, or T-DM1. All participants had HER2-positive metastatic cancer, with no prior chemotherapy for their metastatic disease.

After a median of approximately 6 months of follow-up, the researchers found an overall response rate of 48% in patients administered T-DM1, compared to 41% in the trastuzumab plus docetaxel arm. Importantly, th
'/>"/>

Contact: Vanessa Pavinato
pavinato.vanessa@esmo.org
39-024-342-3649
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Evaluation of targeted therapy in ovarian cancer
2. Moffitt Cancer Center and GLG Pharma LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
3. Moffitt Cancer Center and GLG Pharma, LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
4. Targeted therapy triggers complex mechanism of resistance
5. Synthetic lethality strategy improves molecularly targeted cancer therapy
6. Targeted therapy decreases progression rate in thyroid cancer
7. Targeted agent shows promise for chronic lymphoid leukemia
8. Targeted strategies needed to find, prevent and treat breast cancer among Mexican-origin women
9. In Early Trial, Targeted Therapy Fights Advanced Melanoma
10. New targeted therapy for advanced melanoma associated with 80 percent response rate
11. Targeted drug leads to regression of metastatic melanoma with mutated BRAF gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... 28, 2015 Thousands of transvaginal ... by C.R. Bard, Inc. continue to move forward ... Court, Southern District of West Virginia, where Bernstein ... the Plaintiffs’ Steering Committee. According to an ... certain defendants named in those lawsuits leave to ...
(Date:3/28/2015)... India Network visitor health insurance ... all visitors who purchase the plan before arrival in ... to purchase the insurance program as soon as travel ... for pre-existing medical conditions. Parents and grandparents traveling from ... with serious consequences to their health. Many visitors may ...
(Date:3/28/2015)... Pitching speed, player’s height, and pitching for ... elbow injuries, according to new research released today at the ... Day. , “Our findings indicate that a 10 inch increase ... of a history of injury, a 10 mile per hour ... of a history of injury, and playing for more than ...
(Date:3/28/2015)... 2015 Delaying rotator cuff surgery on ... to research presented today at the American Orthopaedic Society ... “Our study compared results for 170 patients who received ... glenohumeral joint capsule release procedure to relieve stiffness at ... lead author from St. George Hospital in Sydney, Australia. ...
(Date:3/28/2015)... 28, 2015 Andrew Hawley of Vintage Rock ... psychedelic concert posters. The Who and the Doors played together ... 2, 1968. According to Hawley, “The Who toured the United ... and college campuses. Perhaps the most famous Who poster was ... and the Doors on August 2, 1968 at the Singer ...
Breaking Medicine News(10 mins):Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 3Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 4Health News:India Network Health Insurance Today Announces New Eligibility Criteria for Pre-existing Condition Health Insurance Coverage for Visitors to the United States 2Health News:India Network Health Insurance Today Announces New Eligibility Criteria for Pre-existing Condition Health Insurance Coverage for Visitors to the United States 3Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:Avid Collector from Vintage Rock Posters, Inc. Announces His Search For Original 1960's Who Psychedelic Concert Posters. 2
... in two separate transactions-- Industrial staffing business sold-- ... fund DailyMed(TM) growthINDIANAPOLIS, May 19 Arcadia Resources, ... leading provider of home care, medical staffing, and ... announced the sale of two non-strategic businesses. ...
... say the disease is no more dangerous than regular ... World Health Organization may declare a full-fledged swine flu ... has swept through Japan, a former WHO infectious disease ... occurring in a region outside North America, where a ...
... Minn., May 19 Activeion ... that it has increased its commitment to ... membership organization for institutions and businesses in ... in reducing their environmental footprints.(Logo: ...
... the online social network the chance to meet one ... at the site, topics of interest to be discussed ... FertilityTies ( www.FertilityTies.com ), the most comprehensive ... conceive/facing infertility that combines expertise of accredited MDs, will ...
... ( www.apieron.com ) significantly strengthened its senior ... Vice President, Sales & Marketing, and Bryan Miller as ... Bubrick has more than 20 years of operational and ... in diabetes management. Prior to joining Apieron, Mr. Bubrick ...
... MOUNTAIN VIEW, Calif., May 19 Cardiva Medical, Inc. ... U.S. Food & Drug Administration (FDA) for its latest ... first drug coated vessel closure device in the market. ... coated with protamine sulfate, a drug which neutralizes heparin ...
Cached Medicine News:Health News:Arcadia Resources Announces Sale of Non-Strategic Businesses 2Health News:Arcadia Resources Announces Sale of Non-Strategic Businesses 3Health News:Arcadia Resources Announces Sale of Non-Strategic Businesses 4Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 2Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 3Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 4Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 5Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 6Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 7Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 8Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 9Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 10Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 11Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 12Health News:Spread of Swine Flu in Japan Could Raise WHO Alert to Highest Level 13Health News:Activeion Cleaning Solutions, LLC Joins National Health Organization Supporting Environmental Practices 2Health News:Activeion Cleaning Solutions, LLC Joins National Health Organization Supporting Environmental Practices 3Health News:FertilityTies.com Convention Open to the Public, June 6, 1-5 PM at The Hilton New York Hotel, MDs to Lead Discussion on Timely Fertility Topics 2Health News:Apieron Strengthens Senior Leadership With Commercial, Financial Appointments 2Health News:Cardiva Medical, Inc. Receives FDA Clearance for the Catalyst(TM)III System, First in Class Drug Coated Vessel Closure Device 2Health News:Cardiva Medical, Inc. Receives FDA Clearance for the Catalyst(TM)III System, First in Class Drug Coated Vessel Closure Device 3
(Date:3/27/2015)... -- Holographic Optical Technologies of Augusta, Georgia ... is entering the world of consumer electronics with the ... th , 2015, the campaign will introduce the company,s ... displays will allow consumers to view fully three dimensional ... to the two displays, the company will also offer ...
(Date:3/27/2015)... 27, 2015  Victoria Vein & Surgery Clinic is the ... Duality laser in Victoria, Texas . The ... as advanced laser treatments for a variety of medical and ... to provide more services for their patients. Since adding laser ... Victoria residents get rid of their unwanted ...
(Date:3/27/2015)... SAN DIEGO , March 27, 2015 /PRNewswire/ ... informatics company, today announced new data showing that, ... Mantis TM technology provided highly equivalent interpretations ... cause disease, and did so in a fraction ... pave the way for more comprehensive genetic analysis ...
Breaking Medicine Technology:Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3
Manufactured with a radiopaque line running down the length of the tube, position can be easily visualized by x-ray....
The all silicone construction of the shaft and neck flange provides the utmost in patient comfort. , ,The Aire-Cuf® tracheostomy tube offers a more traditional and familiar air-filled cuff desig...
... Extra vertical length tubes are often ... fistulas, stenosis, and tracheal malacia. Available ... features two independently inflatable cuffs. Greater ... possible since cuff sites can be ...
... Bivona® Mid-Range Aire-Cuf® Adjustable Neck ... TTS™ tube except this tube features ... Aire-Cuf®., ,Adult Mid-Range Aire-Cuf® Adjustable ... a trach tie, disconnect wedge, and ...
Medicine Products: