Navigation Links
Targeted therapy prolongs life in patients with HER2-positive breast cancer
Date:12/11/2009

SAN ANTONIO Lapatinib plus trastuzumab are significantly better than lapatinib alone in extending the lives of breast cancer patients whose tumors are HER2-positive, according to Kimberly Blackwell, M.D., associate professor of medicine at Duke University Medical Center. Blackwell presented the findings today at the CTRC-AACR San Antonio Breast Cancer Symposium.

Blackwell says the combination targeted therapy gave patients more than a four-month survival advantage over those who took lapatinib alone. She says the findings may be the first step toward a chemotherapy-free future.

"This is the first time that a pair of targeted therapies has been shown to be superior to any intervention that paired a targeted therapy with a hormonal or chemotherapy based approach," she said.

The results stem from a large, Phase III clinical trial where investigators randomized 296 patients with metastatic breast cancer to receive either lapatinib (also known as Tykerb) alone or lapatinib plus trastuzumab (Herceptin) once a day. All participants had metastatic disease that had continued to spread even after treatments with several interventions that included trastuzumab plus chemotherapy.

Blackwell says trastuzumab binds to and blocks part of the HER2 growth factor that appears on the surface of some breast cancer cells while lapatinib binds to a second growth factor, EGFR, and part of HER2 that sits below the cell surface. "It's sort of a double whammy, disabling the HER2 protein in two places instead of one."

Women who enrolled in the single-agent arm of the study and whose cancer continued to spread after four weeks were allowed to cross over to the other arm of the study to continue on the combined approach.

Fifty-two percent of the women enrolled in the lapatinib-only arm of the study crossed over to the combination arm. The median overall survival following treatment with lapatinib plus trastuzumab was 60.7 weeks compared to 41.4 weeks for those who took only lapatinib.


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-724-5343
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
2. Targeted breast ultrasound can reduce biopsies for women under 40
3. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
4. Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers
5. Hard To Treat Diseases (HTDS) Exploration Of A 25 Billion Dollar Industry Regenerative Medicine and Stem Cell Bank Targeted Merger
6. Senate Votes to Proceed - 60 Plus Announces New 9 State TV Campaign Targeted at Senators to Protect Medicare
7. AEterna Zentaris Announces Positive Preliminary Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Ovarian Cancer
8. Targeted heat therapy offers new standard treatment option for soft tissue sarcoma
9. Narconon Launches Operation Medicine Cabinet in Georgia - Prescription Drugs Commonly Abused Targeted
10. Argonne, University of Chicago Scientists Develop Targeted Cancer Treatment Using Nanomaterials
11. Argonne, University of Chicago scientists develop targeted cancer treatment using nanomaterials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... West Lebanon, NH (PRWEB) , ... January 18, ... ... announces the launch of the revolutionary Active Brake Technology (ABT), an innovative braking ... and stability. , Active Brake Technology addresses one of the biggest concerns of ...
(Date:1/17/2017)... ... January 17, 2017 , ... Anesthesia Progress – Everyone ... choose the best drug option for each patient. Dentists have several general anesthesia alternatives ... outcomes. , Researchers from the Tokyo Dental College in Tokyo, Japan wanted to find ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting interview with medical expert and ... help everyone endure and pass through tough times, Dr. Bernie Siegel energizes listeners ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... music enthusiasts at the National Association of Music Merchants (NAMM) winter trade show, ... 22, 2017. , Etymotic’s ER•4® has long been the gold standard for high-definition, ...
(Date:1/17/2017)... ... January 17, 2017 , ... Medic-CE , a Career ... professionals, has released four new continuing education courses as part of its Code3 ... an online classroom and meet the requirements of the National Continued Competency Program ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017 Safe Rx ... of pharmacies based in Loveland, Colorado ... Vials (LPVs) in selected Good Day locations.     ... a cost-effective alternative for secure storage," said Milton ... less than the price of a cup of coffee, ...
(Date:1/18/2017)... , Jan. 18, 2017 Invetech, ... for cell and advanced therapies , has announced ... biopharmaceutical company developing "tumor starvation" treatments for acute ... needs. Under the agreement, Invetech will develop systems ... on Erytech,s proprietary ERYCAPS technology platform, which uses ...
(Date:1/18/2017)... , January 18, 2017 After ... people regarding the use of cannabis both for medical and ... are more Americans open to the use of cannabis, but ... sectors. According to Arcview Market Research, the North American legal ... 30% from the previous year. The research projects sales will ...
Breaking Medicine Technology: