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Targeted therapy plus chemotherapy may pack 1-2 punch against melanoma
Date:5/14/2008

h ADH-1 and melphalan chemotherapy compared to chemotherapy alone. Tumor size shrunk about twofold in response to ADH-1 and temozolomide, Tyler said.

We saw a complete regression of the tumors in the animal model when we used the regional melphalan chemotherapy in combination with ADH-1, which is far better than anything we have seen before with the chemotherapy alone, Tyler said. Furthermore, the addition of ADH-1 produced no additional side effects, which is an important consideration in cancer treatment.

Regional infusion of chemotherapy for melanoma is given under surgical conditions, through the artery and vein in the affected limbs. Melanoma often affects people on their extremities, with a common scenario being a mole that appears on the foot and then spreads up the leg.

These results clearly demonstrate the effectiveness of combination therapies, said Christina Augustine, Ph.D., a researcher in Dukes Department of Surgery and lead investigator on the study. Used alone the ADH-1 really didnt confer any significant benefit but in combination with the melphalan chemotherapy, we saw a powerful one-two-punch effect.

The incidence of malignant melanoma is increasing at a rate faster than any other cancer, with 60,000 new cases expected to be diagnosed this year in the United States. Melanoma that has spread beyond the primary site is rarely curable, and treatment options are limited; even when it is treated, the response rates are typically poor and most people die within six to nine months.


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Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

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