Navigation Links
Targeted therapeutics for colon cancer to be presented at AACR meeting
Date:4/3/2012

(Boston) - Anurag Singh, PhD, assistant professor in the Department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine has been invited to present his recent work on targeted therapeutics for colon cancer at the American Association of Cancer Research Annual Meeting in Chicago, IL. Singh's seminar, scheduled for Tuesday April 3rd, will be featured in the "Late-Breaking Abstracts Mini-Symposium". This highlights recent and provocative groundbreaking research in cancer biology.

Over one million cases of colon cancer are diagnosed worldwide each year resulting in approximately 600,000 deaths annually. Disease-causing mutations in the KRAS gene are found in over half of these cases. In the United States, colon cancer patients are routinely genotyped for KRAS gene mutations and those with mutations are excluded from receiving novel "targeted" therapeutic agents due to a lack of clinical benefit. Thus, patients with KRAS gene mutations are faced with very limited therapeutic options and are subsequently given very poor clinical prognoses.

Singh and his colleagues have identified a network of genes that are hyper-activated in KRAS mutant colon cancers. Within this network is a gene called MAP3K7 or TAK1, which plays a very critical role in promoting colon cancer disease progression. Pharmacological inhibition of TAK1 results in strong killing of affected tumor cells, with minimal effects in "normal" non-mutated cells. "These findings raise the possibility that anti-TAK1 agents could provide the basis for "personalized" medicine in patients with highly aggressive KRAS mutant colon cancers," said Singh. Efforts are now underway to identify clinically efficacious TAK1 inhibitors.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. 2 targeted therapies act against Ewings sarcoma tumors
2. Targeted drug helps leukemia patients who do not benefit from initial therapy
3. Wayne State proves targeted tumor freezing therapy increases ovarian cancer survival
4. Rowley to receive Japan Prize for her role in the development of targeted cancer therapy
5. Targeted therapy extends progression-free survival of patients with advanced ovarian cancer
6. Targeted Radiation for Breast Cancer May Be Overused: Study
7. Targeted Radiation May Not Be Better for Breast Cancer
8. Targeted Drugs, Lung CT Screening Top Cancer Advances in 2011
9. More Targeted Treatments Key to Progress in War on Cancer: Report
10. First-of-its-kind study creates new tool for targeted cancer drug development
11. Research involving thyroid hormone lays foundation for more targeted drug development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
Breaking Medicine Technology: