Navigation Links
Targeted radiation therapy minimizes GI side effects for prostate cancer patients, Penn study shows
Date:10/26/2010

SAN DIEGO -- Prostate cancer patients who receive intensity modulated radiation therapy (IMRT) are less apt to suffer serious gastrointestinal complications following their treatment than those who receive three-dimensional conformal radiotherapy (CRT), according to new research from the University of Pennsylvania School of Medicine. The study, which will be presented Nov. 1 at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO) in San Diego, found that men who were treated with IMRT had fewer serious bowel complications, including painful rectal inflammation and bleeding (3.5 percent), compared to those who received CRT (4.5 percent).

"While radiotherapy is highly effective in treating prostate cancer, men may live with gastrointestinal, urinary and sexual side effects of treatment for many years. Minimizing these side effects and improving men's quality of life after prostate cancer treatment is incredibly important," says Justin Bekelman, MD, lead author of the study and an assistant professor of Radiation Oncology at the University of Pennsylvania School of Medicine. "Our study offers important evidence to patients and their doctors that IMRT is associated with fewer gastrointestinal problems after treatment."

CRT, the conventional form of radiation therapy, uses imaging studies including CT, MRI and PET scans to map the size, shape and location of tumors and the other organs in the area. IMRT is a more advanced version of CRT, offering a more targeted dose of radiation to the cancerous prostate gland. Since both forms of radiation pass all the way through the body after attacking their target, healthy tissue in the rectum and bladder may be damaged by the radiation beam, causing side effects during and after treatment. Though Medicare and private insurers typically cover both IMRT and CRT, little research has been conducted to show which treatment is associated with less side effects an important consideration for men choosing among the various treatment options for the disease, which include observation, radiation, surgery, chemotherapy and hormonal therapies.

Using a Medicare database of men across the United States, Bekelman's team studied 12,598 men 65 years and older who were diagnosed with non-metastatic prostate cancer between 2002 and 2004. The authors followed the patients through 2006 and identified complications that were serious enough to require invasive procedures (including surgeries) and/or hospitalization. The findings revealed that among men who received IMRT, 18.8 percent had serious bowel complications during the two years after their treatment, compared to 22.5 percent of men treated with CRT. (Since specifics about each patient's case could not be accounted for in the database, the authors note that some of the complications identified may have been caused by factors other than radiation treatment.) The researchers found no substantial difference in incidence of urinary or sexual side effects such as erectile dysfunction, but Bekelman notes that since the study was limited to complications involving invasive surgical procedures, it may not capture the true prevalence of sexual side effects following treatment, for which patients may have sought less invasive remedies.


'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Targeted delivery of losartan reduces liver inflammation and scarring
2. Gene-Targeted Cancer Fix Could Be a Breakthrough
3. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
4. Targeted agent blocked growth of deadly brain cancer in preclinical studies
5. Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients
6. New targeted therapy effective in treating advanced prostate cancer
7. Gene-Targeted Therapy Might Help Prevent Paralysis
8. Site Steering Launches Keyword Targeted Small Business Internet Video Advertising Program That Achieves First Page Search Results Within Days
9. Drug in new class of targeted therapies shows early promise against blood-related cancers
10. Women Smokers Targeted on World No Tobacco Day
11. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... Lehi, Utah (PRWEB) , ... May 24, 2017 , ... ... “Super Sick Kids: The Surprising Truth about Pediatric Septic Shock” hosted by the Journal ... 31, 2017, at 2 p.m. Eastern time, will be presented by Captain Rommie Duckworth, ...
(Date:5/24/2017)... ... May 24, 2017 , ... Adelberg-Montalvan ... dentistry options for its patients on Long Island, New York. , Holistic ... being, and is one of the biggest trends in dentistry today. , ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... food ingredient solutions for the food and beverage industry offers Citri-Fi®, a natural ... statements during the purchasing decision process. As a result, labels need to deliver ...
(Date:5/23/2017)... City (PRWEB) , ... May 23, 2017 , ... ... Population Health and Clinical Integration company, announced today that its iClinic V12.2 ... Home (PCMH) 2017 Prevalidation. NCQA recently introduced PCMH 2017 standards which emphasize ...
(Date:5/23/2017)... ... May 23, 2017 , ... PM360, the premier ... today announced the winners of its 3rd Annual ELITE Awards. The ELITE (Exceptional ... in the healthcare industry today. , Out of more than 500 submissions, 100 ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... Mass. and SAN DIEGO ... Obstetricians and Gynecologists (ACOG) 2017 Annual Clinical and Scientific ... single-use, self-contained, illuminating medical devices, today announced the launch ... of its OfficeSPEC and ER-SPEC ... the addition of extra-small and extra-large sizes makes OBP ...
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
(Date:5/3/2017)... , May 3, 2017 A Catheterization ... hospital or healthcare facility. Commonly referred to as ... equipped with diagnostic imaging technology to give physicians ... heart. In these spaces, a team of physicians ... angioplasty, percutaneous coronary intervention, congenital heart defect closure, ...
Breaking Medicine Technology: