Navigation Links
Targeted nanospheres find, penetrate, then fuel burning of melanoma
Date:2/1/2009

small that they fit through the larger pores of abnormal blood vessels that nourish cancer, Li said. This "passive targeting" delivers a low dose of nanoparticles and concentrates them near the cell's vasculature.

The researchers packaged hollow, spherical gold nanospheres with a peptide - a small compound composed of amino acids - that binds to the melanocortin type 1 receptor, which is overly abundant in melanoma cells. They first treated melanoma cells in culture and later injected both targeted and untargeted nanospheres into mice with melanoma, then applied near-infrared light.

Fluorescent tagging of the targeted nanospheres showed that they were embedded in cultured melanoma cells, while hollow gold nanospheres without the targeting peptide were not. The targeted nanospheres were actively drawn into the cells through the cell membrane.

When the researchers beamed near-infrared light onto treated cultures, most cells with targeted nanospheres died, and almost all of those left were irreparably damaged. Only a small fraction of cells treated with untargeted nanospheres died. Cells treated only with near-infrared light or only with the nanospheres were undamaged.

An 8-fold increase in tumor destruction

In the mouse model, fluorescent tagging showed that the plain hollow gold nanospheres only accumulated near the tumor's blood vessels, while the targeted nanospheres were found throughout the tumor.

"There are many biological barriers to effective use of nanoparticles, with the liver and spleen being the most important," Li said. The body directs foreign particles and defective cells to those organs for destruction.

Most of the targeted nanospheres in the treated mice gathered in the tumor, with smaller amounts found in the liver and spleen. Most of the untargeted nanospheres gathered in the spleen, then in the liver and then the tumor, demonstrating the selectivity and importance of targeting
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study suggests brain tumors need treatment with multiple targeted drugs
2. Data Show SuperGens Multi-Targeted Tyrosine Kinase Inhibitor Demonstrates Pre-clinical Activity in Glioblastoma Multiforme
3. Research suggests targeted treatment strategies for lupus
4. S*BIO Expands Pipeline With the Development of a Unique Flt3 -CDK Inhibitor as a Targeted Therapy for Acute Leukemias
5. Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Assessment of Its Phase I/II Trial of tgAAC94 for Inflammatory Arthritis
6. Gleevec, the targeted cancer pill, delivers more good news to patients
7. OHSU Cancer Institute researcher develops test for targeted therapy in acute myeloid leukemia
8. Light powered platinum more targeted and 80 times more powerful than similar cancer treatments
9. A major step toward a more targeted treatment for auto-immune diseases?
10. NeoStrata Clinical Findings Reveal Benefits of Combining Glycolic Acid Peels and Targeted Home Care With Microdermabrasion for Optimized Treatment of Photodamaged Skin
11. New study of targeted therapies for breast cancer -- model for global clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Targeted nanospheres find, penetrate, then fuel burning of melanoma
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal injury ... the greater Phoenix area and across Arizona reports record ... catastrophic automobile accidents. Statistics have indicated a steady increase ... As such, Hastings and Hastings has seen a steady ... who have been injured through no fault of their ...
(Date:10/19/2014)... 19, 2014 Dr. Babatunde Osotimehin, Executive ... news of a ceasefire agreement that is expected to ... girls who were kidnapped from the north-eastern Nigerian town ... captivity long enough, and it is high time they ... Dr. Osotimehin. , "We owe it to these girls ...
(Date:10/19/2014)... 2014 Recently, Top10BestSEOHosting.com has unveiled ... JustHost, GoDaddy and HostMonster are the best VPS ... Private Server) is the method of partitioning a ... which has the appearance and capabilities of running ... the site pays close attention to VPS products ...
(Date:10/19/2014)... Visual Impact Frequency Training - a ... to the public generating a frenzied buzz of ... community. The commotion surrounding the program's launch has ... an investigative review. , "Many gym-goers are familiar ... known as a training 'plateau' where they are ...
(Date:10/19/2014)... that causes inflammation in the spinal joints and ... ancient Egyptian royal families. Now a new study ... journal of the American College of Rheumatology (ACR), ... condition called diffuse idiopathic skeletal hyperostosis (DISH) in ... 20th Dynasties. , Ankylosing spondylitis is a ...
Breaking Medicine News(10 mins):Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2Health News:Mummy remains refute antiquity of ankylosing spondylitis 2
... offenders' lack of trust in medical professionals means - ... mental distress.// ,Men who have been incarcerated ... and under-utilise mental health services compared to the general ... with a health professional may predict the likelihood of ...
... School of Medicine have demonstrated the potential of a ... high cholesterol// levels. ,The findings are in ... Medicine (NEJM). In this study, patients with homozygous familial ... had a remarkable 51% reduction in low-density lipoprotein (LDL) ...
... tend to succumb more to respiratory infections in winter ... weather, combined with fog, like the capital has been ... viruses to spread that cause influenza type infections, say ... to the ill effects of low temperature. The influenza ...
... deficient in nutrients or calories,// and may not do much ... researchers from University of Ontario said. , ,The study ... hampers, sourced from a well established food bank located in ... the hampers, meant to last three days, contained calories sufficient ...
... studies prove conclusive.// , Scientists claim to have found ... of DNA found at the ends of the chromosome. ,Nilesh ... medical journal, The Lancet, detailed their experiments on 1500 men, in ... the length of their telomere (sampled from white blood cells) found ...
... use of viruses like that of the common cold ... ,Leonard Seymour, a professor of gene therapy at Oxford University, ... ,While the technique, called virotherapy, is not new, it ... which have spread, or in essence cancer cells, which have ...
Cached Medicine News:Health News:Offenders Unlikely to Seek Help 2Health News:New Therapy to Treat Patients With Severely Elevated Cholesterol Levels 2Health News:New Therapy to Treat Patients With Severely Elevated Cholesterol Levels 3Health News:Severe Cold is Harbinger of Infections 2Health News:Humble Cold to Combat Cancer 2
(Date:10/17/2014)... , October 17, 2014 /PRNewswire/ ... and Markets ( http://www.researchandmarkets.com/research/rxznjk/micro_market ) has announced ... Monitor : North American Automated External ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,The report ... 2008-2018 analyzes the market of devices ...
(Date:10/17/2014)... The following is being released by ... The Green Park Collaborative (GPC) will bring together ... medical device and pharmaceutical companies, as well as ... 2015 at its first ever workshop on the ... Participants will discuss study designs to evaluate weight ...
(Date:10/17/2014)... --  InnFocus, Inc ., reported on results of 59 glaucoma ... for up to 3 years with the InnFocus MicroShunt® at ... Chicago . The Summit was ... the American Academy of Ophthalmology . The Company also ... in 6 countries by early 2015. Logo - ...
Breaking Medicine Technology:Micro Market Monitor : North American Automated External Defibrillators (AED) Market 2Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2InnFocus Featured at the Ophthalmology Innovation Summit In Chicago 2
... Healthcare Products, Inc., (NASDAQ: AHPI ) reported ... hospitals and government entities still suffering from recession-driven budget cuts. ... per basic and diluted share, for the 2011 fiscal year compared ... per share, for the previous year. For the quarter, ...
... Sept. 2, 2011 Sigma-Aldrich Corporation (NASDAQ: ... conferences in September: KeyBanc Capital Markets ... 13, at the InterContinental, Boston, MA, presenting at 9:00 ... Wednesday, September 14, at the Grand Hyatt, New York, ...
Cached Medicine Technology:Allied Healthcare Reports Profitable Quarter and Year Despite Lingering Effects of Recession 2Allied Healthcare Reports Profitable Quarter and Year Despite Lingering Effects of Recession 3Allied Healthcare Reports Profitable Quarter and Year Despite Lingering Effects of Recession 4Sigma-Aldrich Corporation to Present at Upcoming Investor Conferences 2
... is a 60 watt diode continuous wave laser ... Diode Power Bar technology and 940 nm wavelength ... treatment for varicose veins and a variety of ... unique safety features including the LPS, Light guide ...
... Innovations' Instrument Manager (IM) is an instrument ... system that enables laboratories to work more ... as a data management solution that stands ... information system, filling those important gaps in ...
70 discs to investigate acquired color deficiency. Quantifies neutral zone characteristics of dyschromatopsia and evaluates the relative luminance....
... of the Farnsworth 100 Hue Test comes boxed ... and reduces the potential for test disruption ... Farnsworth 100 Hue test from Richmond Products includes ... tray, a durable laminated score template for copying, ...
Medicine Products: