Navigation Links
Targeted micro-bubbles detect artery inflammation, MU study finds
Date:12/12/2012

COLUMBIA, Mo. Heart disease is a leading cause of death throughout the world. Doctors say that it is important to detect heart disease early before it becomes too serious. Now, researchers at the University of Missouri have found a way that they believe could help detect heart disease before it progresses too far as well as identify patients who are at risk for strokes.

In a study published in Medicine and Science in Sports and Exercise, Isabelle Masseau, an assistant teaching professor in the MU College of Veterinary Medicine, found that she could use targeted micro-bubbles to detect artery inflammation in pigs. She says that this procedure may help detect patients with heart disease or who are at risk for strokes before those ailments become too serious by monitoring artery inflammation, as that is an early warning sign of health problems. She says this procedure may also help monitor the effectiveness of artery inflammation treatments.

"It can be very difficult to detect early signs of heart disease, especially without the use of invasive procedures," Masseau said. "Doctors often have to wait until serious symptoms occur, such as chest pain or heart attacks, before they are aware of a problem, and many times that is too late. Targeted micro-bubbles have the potential to be able to detect early signs of heart disease very non-invasively."

Early signs of heart disease include inflammation on the insides of arteries, which leads to plaque buildup that could eventually result in heart attacks. Masseau was able to attach specific antibodies to tiny bubbles and then inject those bubbles into pigs with heart disease. The antibodies were able to seek out the inflammation in the pigs' arteries and attach themselves, along with the micro-bubbles, to the inflammatory sites. Then, using an ultrasound machine, Masseau was able to detect the targeted micro-bubbles that had gathered in the arteries of pigs. She says this is the first time the procedure has been successful in large animals.

"Because this procedure was successful in pigs, it also could potentially be reproduced in humans as well," Masseau said. "While it would still be a few years away, injecting targeted micro-bubbles into a human and then scanning them with an ultrasound would be a very simple procedure and could potentially help save lives."

Another part of Masseau's research involved studying pigs to observe the effects exercise has on artery inflammation. Before Masseau detected inflammation in the pigs using the targeted micro-bubbles, she submitted them to cardio exercise and measured its effect. Surprisingly, the exercise did not have any effect on reducing the arterial inflammation; however Masseau says that this does not mean that exercise is not important for heart health.

Masseau was joined in this study by Doug Bowles, a professor in the department of biomedical sciences in the MU Dalton Cardiovascular Research Center, and Michael Davis, a professor and associate head of the department of medical pharmacology and physiology in the MU Dalton Cardiovascular Research Center.

The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, MU officials will request authority from the federal government to begin human trials. After this status has been granted, researchers may conduct human clinical trials with the hope of developing new treatments for heart disease.

This research is an example of the One Health/One Medicine area of Mizzou Advantage. Mizzou Advantage is a program that focuses on four areas of MU strength: food for the future; media of the future; one health/one medicine; and sustainable energy. The goals of Mizzou Advantage are to strengthen existing faculty networks, create new networks and propel Mizzou's research, instruction and other activities to the next level.


'/>"/>

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
10. Deadly witch hunts targeted by grassroots womens groups
11. Large lung cancer study shows potential for more targeted therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... Rosa, CA (PRWEB) , ... March 30, 2017 , ... ... in March suggests that following joint replacement surgery – the best place for a ... is expedited when they are in familiar surroundings and have ample opportunity to rest ...
(Date:3/30/2017)... ... 30, 2017 , ... The Aresty Institute of Executive Education ... to address the increasingly complex educational needs of today's global executives. Corporate ... corporate finance and will increase their ability to confidently take action in ways ...
(Date:3/30/2017)... ... , ... An inventor and manicurist from Greet, S.C., wants to offer people a new way ... maintain clean and healthy feet, so I know the importance of proper foot care," he ... designed the FOOT-TRAN SYSTEM." , The FOOT-TRAN SYSTEM enables a user to clean and exfoliate ...
(Date:3/30/2017)... Durham, NC (PRWEB) , ... March 30, 2017 ... ... professionals, will host the live audio conference “ Preventing Hospital Readmissions Through Discharge ... April 12, 2017 at 1:00 pm ET. This conference discusses strategies to prevent ...
(Date:3/29/2017)... ... , ... During the last week of March, Chad Kawa, MD of Revere ... the local community. , Colon cancer is the second leading cause of cancer ... it is small, confined and easier to treat. If you are 50 or older, ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... DUBLIN , Mar. 29, 2017 Research and ... Market, Reimbursement Policy, Patients Treated at Proton Therapy Centers & Forecast" ... ... 2021 from its current market size in 2016. The Untapped Proton Therapy ... than 1 Billion USD in 2016. Proton Therapy plays ...
(Date:3/29/2017)... 2017  Zynex (OTCQB: ZYXI), an innovative medical technology company ... devices for pain management, stroke rehabilitation, cardiac monitoring and ... Company,s 2016 full-year investor webcast on Monday, April 3, 2017 at 9:00 ... Company expects to file its 2016 full year financial ... ...
(Date:3/29/2017)... March 29, 2017 According to a new market ... (Gas-Filled Detectors, Geiger Muller, Survey Meter, Solid-State), Products (Personal Dosimeters, OSL, Badges), ... published by MarketsandMarkets, the market is expected to reach USD 1,215.4 Million ... 6.5% from 2016 to 2021. Continue Reading ... ...
Breaking Medicine Technology: