Navigation Links
Targeted investigational therapy potential to overcome crizotinib resistance in lung cancers
Date:10/20/2013

BOSTON PF-06463922, an investigational drug being developed by Pfizer Inc., has the potential to become a new treatment option for patients who have lung cancer harboring abnormalities in the ALK gene, according to preclinical results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19-23.

About 3 to 5 percent of lung cancers harbor ALK gene abnormalities. The drug crizotinib (Xalkori), which blocks ALK protein kinase activity, was approved in August 2011 by the U.S. Food and Drug Administration for the treatment of patients who have these lung cancers. Although robust responses to crizotinib are observed for lung cancers harboring ALK gene abnormalities, the majority eventually become resistant to the effects of the drug. In many cases, resistance arises because of genetic mutations in ALK.

"Resistance to targeted therapies such as crizotinib is a major challenge when treating patients with cancer," said Tod Smeal, Ph.D., associate research fellow in the Oncology Research Unit at Pfizer Inc. in San Diego, Calif. "Our goal is to take advantage of everything we have learned about designing drugs that target kinases like ALK and the ways in which lung cancers become resistant to crizotinib to develop the best next-generation ALK inhibitor we can.

"Our preclinical studies suggest that we are making progress toward achieving our goal: PF-06463922 has potent ALK-inhibiting activity, it is capable of inhibiting all the crizotinib-resistant ALK mutants so far detected in patients, and it can efficiently access the brain. We are excited about these preclinical results and very hopeful that they will translate into meaningful responses in the clinic."

After carefully designing PF-06463922, Smeal and colleagues first showed in cell assays that it potently inhibited the activity of ALK and all eight of the mutant forms of ALK known to cause resistance to crizotinib
'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
10. Deadly witch hunts targeted by grassroots womens groups
11. Large lung cancer study shows potential for more targeted therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Diego, California (PRWEB) May 29, 2015 A ... Core” and have joined the national effort to teach this ... parents in the U.S. have been “sickened” by the recent ... However, love it or hate it, Common Core is now ... District of Columbia. Parents are now seeking ways to ...
(Date:5/29/2015)... The print component of “Skin Health” is ... 250,000 and an estimated readership of 750,000. The digital ... strategy, and across a network of top news sites ... the campaign, click here. , Lucy Liu ... actress, model and producer details her skin care routine, ...
(Date:5/29/2015)... Chicago, Ill (PRWEB) May 29, 2015 ... Care , a dozen medical pioneers recognized by a ... changed the course of cancer treatment. Honorees will be ... of Cancer Care™ Award Ceremony, held 8:30-11:00 p.m. CDT ... , The 2015 honorees are being recognized for groundbreaking ...
(Date:5/29/2015)... Oaksterdam University, the first cannabis college in America, will ... popular and highly demanded Basic and Advanced Classic Seminars ... to 5:30 pm each day. Certification is available upon completion of ... held on June 14 from 12:00 pm to 6:00 pm. Both ... Plaza Hotel & Casino in downtown Las Vegas. , ...
(Date:5/29/2015)... Designed with the versatile athlete in mind, ... all new, exclusive line of supplementation called The 24/7 ... and greatest, high impact, result driven ingredients that have ... 24/7 Series can be used by anyone from bodybuilders ... fitness enthusiasts. There are no stimulant based ingredients that ...
Breaking Medicine News(10 mins):Health News:Doctors Discover a Cure for the Common Core 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 4Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 2Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 3Health News:BPI Sports and Bodybuilding.com Partner Up to Bring an Innovative New Line of Supplements 2Health News:BPI Sports and Bodybuilding.com Partner Up to Bring an Innovative New Line of Supplements 3
... seen with cirrohosis but aren,t sensitive enough , , ... to detect esophageal bleeding in people with cirrhosis show ... researchers. , About 25 percent of patients with cirrhosis ... veins commonly seen with cirrhosis. Variceal bleeding can cause ...
... movement, serious complications can follow, experts note , , TUESDAY, ... identified a marker that might predict which pregnant women ... essentially a baby,s first bowel movement, excreted in the ... is considered a sign of fetal distress. A small ...
... London, New Delhi, and Singapore (6 May, 2008) ... manage patients with depression has challenged the rationale behind ... behavioural therapy (CBT) for milder depression. , According ... is a lack of evidence for CBT being more ...
... with state and local public health agencies for,Community ... The Community Coalitions Health,Institute (CCHI), a 501(c)(3) affiliate ... that it has received a five-year grant from ... improvement in,community health systems across the country. The ...
... WHAT: On national grassroots lobby day, Lance Armstrong to visit four ... * TUESDAY, MAY 13, 2008 WHERE: Tour of Ralph ... (RLC) and RLC Fifth Anniversary Celebration at the Marcus ... 1919 Madison Avenue (Entrance on 124th Street) ...
... WASHINGTON, May 6 The latest,"gaming for health" ... games (e.g., a "disease" being unleashed inadvertently,on the ... videogames,used to train emergency medical personnel -- will ... event at 1 p.m. EDT Thursday,(May 8, 2008)., ...
Cached Medicine News:Health News:Noninvasive Procedures Show Promise for Esophageal Bleeding 2Health News:Doctors Discover Marker for Meconium Passage During Delivery 2Health News:Antidepressants do work in depression while evidence for CBT is poorer say experts 2Health News:Antidepressants do work in depression while evidence for CBT is poorer say experts 3Health News:NBCH's Community Coalitions Health Institute Receives CDC Grant 2Health News:Lance Armstrong Marks 5th Annual LIVESTRONG(TM) Day with Nationwide Fly-Around 2Health News:Video Gaming for Health: Major New Trends to Be Discussed as National Conference Gets Underway 2
(Date:5/29/2015)... Actinobac Biomed, NovoPedics, Inc. and MentiNova, Inc., ... Foundation Venture Capital Group (FVCG), have been selected to ... of the Start-Up Stadium and Company Presentation forums offered ... Golubieski . The annual convention, the largest ... in Philadelphia in June. ...
(Date:5/29/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hgs483/cardiovascular ... new report "Cardiovascular Drug Delivery - Technologies, ... Drug delivery to the cardiovascular system is ... the anatomy and physiology of the vascular system; ... of the body. Drugs can be introduced into ...
(Date:5/29/2015)... DIEGO and BOSTON , ... leader in instrument development, custom automation, and contract manufacturing, ... of the Nanopatch™ needle-free drug delivery technology, have been ... development of the Nanopatch Jet Coating Instrument , ... delivery research and product development.  The award was announced ...
Breaking Medicine Technology:Foundation Venture Capital Group Portfolio Companies to be Highlighted at Bio International in June 2Foundation Venture Capital Group Portfolio Companies to be Highlighted at Bio International in June 3Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 2Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 3Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 2Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 3
... 2011 Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... and commercialization of products for central nervous system disorders, ... and CEO will deliver a corporate presentation on Thursday, ... The presentation will take place as part of the ...
... Bionovo, Inc. (NASDAQ: BNVI ), a pharmaceutical company ... treatments for women,s health and cancer, today announced it will ... their lead drug candidate for postmenopausal symptoms, Menerba ™ ... 13th Annual World Congress on Menopause in Rome, Italy on ...
Cached Medicine Technology:Bionovo to Present the Clinical Promise of Menerba (MF101) for Postmenopausal Vasomotor Symptoms at World Congress on Menopause 2Bionovo to Present the Clinical Promise of Menerba (MF101) for Postmenopausal Vasomotor Symptoms at World Congress on Menopause 3Bionovo to Present the Clinical Promise of Menerba (MF101) for Postmenopausal Vasomotor Symptoms at World Congress on Menopause 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: