Navigation Links
Targeted gene silencing drugs are more than 500 times more effective with new delivery method
Date:12/21/2012

New Rochelle, NY, December 20, 2012Small interfering RNAs (siRNAs) are a potent new drug class that can silence a disease-causing gene, but delivering them to a target cell can be challenging. An innovative delivery approach that dramatically increases the efficacy of an siRNA drug targeted to the liver and has made it possible to test the drug in non-human primates is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Nucleic Acid Therapeutics website (http://www.liebertpub.com/nat).

In the article "Co-Injection of a Targeted, Reversibly Masked Endosomolytic Polymer Dramatically Improves the Efficacy of Cholesterol-Conjugated Small Interfering RNAs In Vivo" (http://online.liebertpub.com/doi/full/10.1089/nat.2012.0389) Wong and colleagues from Arrowhead Madison Inc. (Madison, WI) present a novel strategy to overcome the difficulty in delivering high levels of a gene knockdown siRNA drug to liver cells. While the cholesterol-conjugated siRNA drug is taken up preferentially by the liver, it is encapsulated in membrane-bound globules called endosomes and cannot reach the cells' DNA to exert its gene silencing effect. The researchers co-injected a polymer with the drug that also targets the liver and, once inside liver cells, breaks open the endosomes, releasing the siRNA drug.

"The promise of siRNAs is as strong as ever and is becoming even more so with progress in delivering these molecules to the right place at the right time," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "The work by Wong and colleagues is another important step towards realizing this promise."


'/>"/>
Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related medicine news :

1. Complexities of human disease targeted with $16 million in funding
2. Targeted micro-bubbles detect artery inflammation, MU study finds
3. Weekly dose reduces targeted drugs side effects, but not its activity against ALL
4. Targeted prostate biopsy has potential to improve diagnosis of prostate cancer
5. Targeted Prostate Cancer Biopsies Might Improve Care: Study
6. Researchers report first success of targeted therapy in most common non-small cell lung cancer
7. New targeted therapy for advanced prostate cancer shows anti-tumor activity in clinical trials
8. Temple researchers show targeted cancer drug may stunt hearts ability to repair itself
9. Large lung cancer study shows potential for more targeted therapies
10. Deadly witch hunts targeted by grassroots womens groups
11. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Targeted gene silencing drugs are more than 500 times more effective with new delivery method
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 MarijuanaDoctors.com ... California physician, James Patel M.D. of Livermore, California. As ... best and most qualified physicians, and in accordance with ... our patients to Dr. Patel’s practice. , Initially finding ... a young age, Dr. Patel was shaped by his ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 The need for ... over the past few years. The new location - 4700 ... higher quality and larger office space than TLC had in ... , “We are pleased about our new location because it ... our suite will be double in size compared to the ...
(Date:8/27/2014)... Author and orthopedic surgeon William H. Simon’s ... thrilling adventures of sharp and witty Dr. Ham ... up for a new marketing push in the second ... , “Prescription: Murder” follows the adventures of Ham Marks, ... attempts and thwarting criminals. In the first novella, “Over ...
(Date:8/27/2014)... an innovative company that provides many kinds of top quality ... are now offered on its website. In addition, the firm ... that place an order for its newly released items can ... , The company’s senior spokesman was excited to talk ... and old customers can buy cheap bamboo panels on our ...
(Date:8/27/2014)... National Resident Matching Program International (NRMPI) ... Education in Europe (AMEE) Conference being held at the ... September 3, 2014. As an exhibitor, NRMPI will ... share the benefits of its matching services, and discuss ... countries throughout the world. , “Exhibiting at ...
Breaking Medicine News(10 mins):Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 3Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 4Health News:William H. Simon Launches New Marketing Campaign for Book 2Health News:BambooIndustry.com: Cheap Bamboo Panels for Clients Worldwide Offered Online 2Health News:National Resident Matching Program International (NRMPI) to Exhibit at the 2014 AMEE Conference 2
... CRANSTON, R.I., Nov. 27 A new, ... manufacturers (OEMs) on choosing the,right electronics manufacturing ... available free to download at, http://www.federalelec.com/medicalpaper ., ... need for consistent quality and,conformance to product ...
... 27, 2007, 4:00 p.m. E.S.T. - Positron emission tomography ... need for more accurate staging of lung cancer and ... published online today in Journal of National Cancer Institute. ... Cancer Disease Site Group of Cancer Care Ontarios Program ...
... Nov. 27 A new study that shows young ... for men has leveled off offers,strong evidence that preventive ... war on cardiovascular disease, said Christopher T. Fey, the,chairman ... released study published in Journal of the American College ...
... therapies, experts say , , TUESDAY, Nov. 27 (HealthDay News) ... doctors predict which postmenopausal women are likely to sustain ... algorithm includes 11 different factors -- such as age ... of different ethnic backgrounds. , "Knowing the 5-year ...
... Risk Elevated in Male BRCA Mutation Carriers , Men with ... of breast cancer than the general population. , Male breast cancer ... the U.S., and it is most common in men with a ... who carry mutations in the BRCA2 gene have a greater risk ...
... R.I. [Brown University] Heavy smoking and drinking are ... human papillomavirus type 16 (HPV16), a common strain of ... for head and neck cancer, which affects about 500,000 ... however, shows that alcohol and tobacco use doesnt further ...
Cached Medicine News:Health News:White Paper Details How to Choose the Right EMS Provider for Medical Products Outsourcing 2Health News:PET imaging significantly enhances standard imaging in lung cancer staging 2Health News:US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care 2Health News:US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care 3Health News:Criteria Predict Women's 5-Year Risk for Fracture 2Health News:Other Highlights in the Nov. 27 JNCI 2Health News:Other Highlights in the Nov. 27 JNCI 3Health News:Other Highlights in the Nov. 27 JNCI 4Health News:Drinking and smoking don't boost HPV-related cancer risk 2
(Date:8/27/2014)... -- China Nepstar Chain Drugstore Ltd. (NYSE: ... retail drugstore chain in China based on the ... unaudited financial results for the second quarter ended June ... ended June 30, 2014: , Revenue increased by ... million in the second quarter of 2013 ...
(Date:8/27/2014)... , Aug. 27, 2014 TWi Pharmaceuticals, ... approval from the United States Food and Drug ... (ANDA) for megestrol acetate 125mg/ml oral suspension, the ... is the first-to-file and under Hatch Waxman rules, ... marketing exclusivity.  TWi has completed the pre-launch preparation ...
(Date:8/27/2014)... , Aug. 27, 2014 ... report: Collaborative R&D Terms & ... https://www.reportbuyer.com/product/2276220/Collaborative-RD-Terms--Agreements-in-Pharma-Biotech-and-Diagnostics.html The Collaborative ... and Diagnostics report provides comprehensive understanding and ... and agreements entered into by the worlds ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 11TWi Pharmaceuticals Receives US FDA Final Approval on Generic Megestrol Acetate 125mg/ml Oral Suspension 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 4Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 5Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 6Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 7Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 9
... Inc. (NYSE: SMA ), a leading independent provider ... other medical markets, announced today updated full year 2009 ... flow resulting from lower than anticipated customer demand for ... markets, Symmetry is adjusting its previously stated annual revenue ...
... 26 Ethicon Endo-Surgery today announced results from two ... in three common procedures resulted in a reduced rate ... a difference of more than $15,000 on average for ... study compared two types of minimally invasive hysterectomy procedures ...
Cached Medicine Technology:Symmetry Medical Updates Full Year 2009 Financial Guidance 2Symmetry Medical Updates Full Year 2009 Financial Guidance 3New Studies Demonstrate Benefits of Minimally Invasive Hysterectomy and Colectomy When Compared to Open Surgery 2New Studies Demonstrate Benefits of Minimally Invasive Hysterectomy and Colectomy When Compared to Open Surgery 3New Studies Demonstrate Benefits of Minimally Invasive Hysterectomy and Colectomy When Compared to Open Surgery 4New Studies Demonstrate Benefits of Minimally Invasive Hysterectomy and Colectomy When Compared to Open Surgery 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: