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Targeted drug therapy found effective in patients with common form of immune-mediated kidney disease
Date:8/5/2008

ually achieved a complete remission of their disease, seven of whom provided consent to participate in further evaluations, including additional kidney biopsies. In these patients, deposits of autoantibodies eventually disappeared or were almost entirely reabsorbed and the damage originally noted in certain kidney structures significantly healed.

According to Dr. Ruggenenti, "This represents the first demonstration that kidney injury in membranous nephropathy can regress after selective depletion of B cells. Thus, the present data provide a strong rationale for using rituximab to treat patients with membranous nephropathy."

The authors concluded that their study suggests that the functional and biological abnormalities of membranous nephropathy can be reverted with a safe and selective drug. "Whether this may apply to other [similar kidney conditions] and may translate into long-term protection from renal function loss and the potentially life-threatening complications remains to be established," they wrote.


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Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

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