Navigation Links
Targeted drug may prolong survival of patients with cervical cancer
Date:3/9/2014

A new clinical study has found that erlotinib, a targeted antitumor agent, has promising potential to improve treatment for cervical cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results indicate that larger trials are warranted to determine whether the drug should become part of standard therapy for women with the disease.

Nearly half a million new cases of cervical cancer are reported worldwide each year, making it the third most common cancer among females. Despite the widespread use of screening programs and the recent advent of vaccines against human papilloma virus, cervical cancer continues to be a significant public health problem.

Cisplatin-based chemoradiation is the standard therapy for locally advanced cervical cancer. Unfortunately, treatment responses are unpredictable and often disappointingly brief. A potentially promising new treatment strategy involves targeting the epithelial growth factor receptor (EGFR), which is frequently overexpressed in cervical cancer. Inhibiting this receptor is known to have antitumor effects against a variety of cancers.

Anglica Nogueira-Rodrigues, MD, PhD, of the Brazilian National Cancer Insitute, and her colleagues designed a phase 2 clinical trial to test the potential of the EFGR inhibitor erlotinib combined with chemoradiation therapy in 36 women with cervical cancer. Median duration of therapy was 77 days and median follow-up time was 59.3 months.

The therapy was well tolerated overall, and 34 patients (94.4 percent) achieved a complete response (meaning the disappearance of all cancerous lesions). After two years, 91.7 percent of women were alive, and 80.6 percent experienced no progression of their disease. After three years, 80 percent of women were alive, and 73.8 percent experienced no disease progression.

"While cervical cancer is a neglected disease and very few clinical trials have been reported
'/>"/>

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
201-748-6358
Wiley
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
10. Deadly witch hunts targeted by grassroots womens groups
11. Large lung cancer study shows potential for more targeted therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... . All the work that is done is performed ... upon helping our clients in maintaining their confident beautiful smiles. ... and this problem needs to be addressed as soon as ... a key role in shattering one’s confidence but they also ... importance of this problem, Lewis Clinic has started dental implants ...
(Date:3/31/2015)... 31, 2015 With nationwide predictions of ... phenomenon known as the pineapple express, the OPP is ... insurance. FEMA , "Protecting Your Business" 09/23/2014, ... tips for protecting your business. , Here are 3 ... Almost 40% of small businesses never reopen their ...
(Date:3/31/2015)... 31, 2015 Telemedicine technology is ... specialists at Barnes-Jewish Hospital to patients at Memorial ... Illinois Healthcare (SIH) system. , “Previously, when an ... maternal-fetal medicine consultation, she had to travel two ... and then talk with a Barnes-Jewish specialist,” says ...
(Date:3/30/2015)... A new legal resource site ... members who may have been prescribed Zofran, or it’s ... The site was created in response to the plea ... No. 11-10398-RWZ, filed with the United States District Court ... that this case alleged that GlaxoSmithKline gave doctors kickbacks ...
(Date:3/30/2015)... March 31, 2015 Thomas Peither ... most respected inspection readiness professionals — will conduct ... through the inspection process. , Attendees will learn ... investigator and what they look for when conducting ... exercises and roundtable discussions. This will assure attendees ...
Breaking Medicine News(10 mins):Health News:3 Statistics Every Business Owner Should Know About Flood Waters and Flood Insurance, from the Optometric Protector Plan® 2Health News:Access to Maternal-fetal Experts Expands into Rural Communities 2Health News:Access to Maternal-fetal Experts Expands into Rural Communities 3Health News:Robert Gardner Law Announces Resource Site for Patients Prescribed Zofran During Pregnancy 2Health News:FDAnews Announces — GMP Inspections in Europe: Proven Strategies on How to Prepare Investigations, June 10-11, 2015, Frankfurt, Germany 2Health News:FDAnews Announces — GMP Inspections in Europe: Proven Strategies on How to Prepare Investigations, June 10-11, 2015, Frankfurt, Germany 3Health News:FDAnews Announces — GMP Inspections in Europe: Proven Strategies on How to Prepare Investigations, June 10-11, 2015, Frankfurt, Germany 4
... known for a long time that mutual antagonism between husband ... It has now been possible to pinpoint the exact reason. ... of coronary arteries (atherosclerosis) in women while controlling behavior of ... in men. ,Dr. Tim Smith and fellow researchers ...
... cancer, new research seems to say, as vaccines for ... ingredient//. ,Vaccines work by allowing the body’s immune system ... the immune system finds it difficult to distinguish the ... researchers at University College London (UCL) have been able ...
... scientists from University of New South Wales have ... inflammatory stages of glandular fever// could lead to chronic ... be related to specific regions of the brain that ... fatigue. An acute glandular fever infection could damage ...
... from a crippling mosquito-borne virus disease the Chikungunya fever. It ... area//. The World Health Organization (WHO) said that the ... Ocean region. ,This disease has no cure or ... Mauritius and Seychelles since January. The disease was first recognized ...
... it was found that GlaxoSmithKline Plc which funded the ... in infants// said that the vaccine was viable. GlaxoSmithKline ... ,Roman Prymula, who led the study at the Czech ... necessary before the vaccine hits the market. ...
... Trust plastic surgeons to be greedier! Not satisfied with ... a French woman, plastic surgeons are hungry to perform ... March issue of Plastic and Reconstructive Surgery? (PRS), the ... Surgeons (ASPS), U.S. plastic surgeons demonstrated the procedure of ...
Cached Medicine News:Health News:Heart disease: Men Are From Mars, Women From Venus 2Health News:Brain Injury, A Consequence Of Glandular Fever Could Trigger Fatigue Syndrome 2Health News:Threat from Chikungunya, No Longer a Fear 2
(Date:3/30/2015)... , 31 mars 2015  Une équipe de ... structure atomique d,un récepteur de surface cellulaire ... formation de thromboses. Contre toute attente, cette ... nouvelles caractéristiques structurelles qui remettent en cause ... sur les récepteurs couplés aux protéines G ...
(Date:3/30/2015)... Va. , March 30, 2015  Researchers ... the Marshall University Joan C. Edwards School of ... entitled, "PSEN1 Variant in a Family with Atypical ... genetically confirmed to have a known variant of ... drug Bryostatin 1. Genetically confirmed Alzheimer,s patients as ...
(Date:3/30/2015)... NEW YORK , March 30, 2015  Check-Cap ... diagnostics company focused on the development of a preparation-free ... screening for colorectal cancer, announced today that its CEO, ... the March 31, 2015 trading day.  Neev and Check-Cap ... to commemorate the company,s initial public offering and simultaneous ...
Breaking Medicine Technology:De nouvelles structures moléculaires remettent en cause les idées conventionnelles concernant l'action des médicaments sur les récepteurs 2De nouvelles structures moléculaires remettent en cause les idées conventionnelles concernant l'action des médicaments sur les récepteurs 3Severe Alzheimer's Patient Responds to Bryostatin Treatment 2Severe Alzheimer's Patient Responds to Bryostatin Treatment 3Severe Alzheimer's Patient Responds to Bryostatin Treatment 4Severe Alzheimer's Patient Responds to Bryostatin Treatment 5Check-Cap to Celebrate Initial Public Offering with NASDAQ Closing Bell Ceremony on March 31, 2015 2Check-Cap to Celebrate Initial Public Offering with NASDAQ Closing Bell Ceremony on March 31, 2015 3
... 2011 Novus Scientific Pte. Ltd today announced that it ... of receiving its anticipated CE Mark approval this year for ... 1st Long-Term Resorbable Synthetic Mesh. To mark the ... 11th 2011 at the Zebrastraat venue in Ghent  ( http://www.novusscientific.com/events/ ...
... Methodist West Hospital (MWH), of West Des Moines, ... Rauland,s new Responder 5 Nurse Call communication system in ... Department (ED) treatment rooms, as well as the Maternity ... wireless phones, MWH created a quiet, healing environment that ...
Cached Medicine Technology:TIGR® Matrix Surgical Mesh - Exhibited Ahead of Anticipated CE Mark Approval at European Hernia Society 2011, Ghent, Belgium 2A Quiet Healing Environment Created by Nurse Call? 2A Quiet Healing Environment Created by Nurse Call? 3A Quiet Healing Environment Created by Nurse Call? 4
... Horizontal Mini Gel Kit. Gel ... one comb and tapered baffles for casting ... UV transparent. Available in clear, blue, ... supplies, gel trays, gel casters, single and ...
... advantages for nucleic acid separation, and have ... biologist. Agarose gels are easy to cast ... sample underlaying and prevent electrical field discontinuities ... Horizontal systems are more economical and easier ...
... The Mini-Sub cell GT system, ... is used for submerged horizontal gel ... format 7 x 10 cm agarose ... cell, 7 x 10 cm UV-transparent ...
Wide Mini ReadySub-Cell GT Cell, includes buffer tank, lid and electrodes, leveling bubble; accommodates 20-well, 32-well, and 2 x 32-well wide mini ReadyAgarose gels...
Medicine Products: