Navigation Links
Targeted drug helps leukemia patients who do not benefit from initial therapy
Date:2/26/2012

A new study has found that patients with chronic myeloid leukemia (CML) who have not responded to interferon treatments experience long-term benefits when they switch to the targeted drug imatinib. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study indicates that imatinib is the treatment of choice for these patients.

Imatinib, a drug that blocks the protein made by a particular cancer-causing gene, has revolutionized the treatment and prognosis of patients with CML. Now up to 93 percent of patients who take the drug as initial therapy for CML survive at least eight years, whereas prior to imatinib, patients survived an average of only three to six years.

While imatinib is now the standard drug given after a diagnosis of CML, approximately 15,000 to 20,000 patients in the United States may have started taking imatinib after failing to respond to the previous standard drug for CML, interferon. Like patients who now take imatinib as initial therapy for their cancer, these patients seem to respond well to imatinib, at least in the short term; however, little is known about their long-term prognosis.

To investigate, Hagop Kantarjian, MD, of the University of Texas MD Anderson Cancer Center in Houston, and his colleagues analyzed 368 CML patients from their institution who started taking imatinib after failing to respond to interferon. The team estimated that 68 percent of patients survived for at least 10 years. Previous research indicates that only 20 to 30 percent of patients who do not respond to interferon therapy and have no access to imatinib survive this long.

According to the authors, these findings suggest that most patients can benefit from imatinib after unsuccessful interferon treatments, and they do not have to consider other therapeutic options.


'/>"/>

Contact: Amy Molnar
healthnews@wiley.com
201-748-8844
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Targeted delivery of losartan reduces liver inflammation and scarring
2. Gene-Targeted Cancer Fix Could Be a Breakthrough
3. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
4. Targeted agent blocked growth of deadly brain cancer in preclinical studies
5. Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients
6. New targeted therapy effective in treating advanced prostate cancer
7. Gene-Targeted Therapy Might Help Prevent Paralysis
8. Site Steering Launches Keyword Targeted Small Business Internet Video Advertising Program That Achieves First Page Search Results Within Days
9. Drug in new class of targeted therapies shows early promise against blood-related cancers
10. Women Smokers Targeted on World No Tobacco Day
11. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... 22, 2014: The Association for Molecular Pathology (AMP) ... of Molecular Diagnostics on recommendations for a ... master,s levels of education. The report was prepared ... Force of the AMP Training and Education Committee. ... of educating future medical laboratory scientists appropriately in ...
(Date:4/22/2014)... NY, April 22, 2014Hemoglobin A1c is the standard measurement ... diabetes. Blood levels of A1c are typically measured every ... developed a data-based model that accurately estimates A1c using ... Diabetes Technology & Therapeutics ( DTT ), a ... article is available free on the DTT ...
(Date:4/22/2014)... To help rein in massive health care spending, a ... urgently find ways to incentivize pharmaceutical companies and device ... Instead of examining existing medical technologies and their use, ... affect what drugs and medical devices get created in ... health care spending with as little loss of health ...
(Date:4/22/2014)... 10 Americans support mandated coverage of birth control medications, ... the University of Michigan Health System. , Women, blacks, ... at home, and adults with private or public insurance ... universal coverage of birth control medications, according to the ... American Medical Association ( JAMA ). , Individuals ...
(Date:4/22/2014)... German . Scientists ... Vienna and the Medical University of Vienna, together with colleagues ... RNA, such as viral genetic information, is prevented from entering ... viral infection, the protein ADAR1 moves from the cell nucleus ... inhibit reproduction of the virus. But how is the human ...
Breaking Medicine News(10 mins):Health News:AMP publishes curriculum recommendations for medical laboratory scientists 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 3Health News:More than two-thirds of Americans support mandated coverage of birth control in health plans 2Health News:How the body fights against viruses 2Health News:How the body fights against viruses 3
... government, through the U.S. Agency for International Development (USAID), is ... Assistance Response Team (DART) to help combat the cholera outbreak ... than $4.6 million for emergency water, sanitation, and hygiene program ... , This new funding will provide additional ...
... 11 Mary Beth Bolton, MD, FACP, a Detroit internal ... by the Michigan State Medical Society (MSMS). , ... Chief Medical Officer with Health Alliance Plan (HAP) since 2000, ... career-long commitment to improving primary patient care through increasing access, ...
... to "Tell Their Stories" , , ... that healthcare reform will be a top priority in his ... serve as health and human services secretary, is the leader ... to help with reform efforts by sharing their healthcare experiences ...
... million people die every year from infectious diseases, ... The discovery of penicillin to treat bacterial ... previously incurable virus diseases such as polio and ... mid-20th century. , Recently, spectacular advances in medical ...
... company, announced today that beginning January 1, 2009, ... for incomplete spinal cord injury patients suffering from ... Medicare and Medicaid Services (CMS) establishes a new ... devices including the NESS L300™ Foot Drop System. ...
... GLENVIEW, IL, Dec. 11, 2008 Federal funding for pain research ... according to a new study published in The Journal of ... only 0.6 percent of all grants awarded by the National Institutes ... the U.S. , "This startling finding shows the government,s ...
Cached Medicine News:Health News:USAID Provides Additional $6.2M for Zimbabwe Cholera Outbreak 2Health News:Mary Beth Bolton, MD, Named 'Woman Physician of the Year' by Michigan State Medical Society 2Health News:Hospice Community Encouraged to Respond to Daschle Request to Participate in Information Gathering about Healthcare Concerns 2Health News:Mathematical models of adaptive immunity 2Health News:Mathematical models of adaptive immunity 3Health News: Medicare to Reimburse for the Bioness L300™ Foot Drop System for Spinal Cord Injury 2Health News: Medicare to Reimburse for the Bioness L300™ Foot Drop System for Spinal Cord Injury 3Health News:Study shows major pain research funding decline at NIH 2
(Date:1/14/2014)... North America,s leading business partnering event ... 30 th edition of its annual conference at the ... 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... specialty chemical companies will take part in the conference, which ...
(Date:1/14/2014)... Emergency Critical Care, a LifeCentre partner practice, located at 165 Fort ... first in Loudoun County to receive a ... M. Barnes , Medical Director, is a well-seasoned veterinarian of more ... , are avid scuba divers. "As altitude skiers and hikers, we ...
(Date:1/14/2014)... 14, 2014 Equashield ( http://www.equashield.com ... drugs, today announced that it has achieved 60% ...   Equashield,s closed systems reduce the ... and other medical professionals who prepare and administer ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
...  Cell Therapeutics, Inc. ("CTI") (NASDAQ and MTA: CTIC) ... granted a positive opinion for conditional approval from ... Products for Human Use ("CHMP"). Based on the ... authorization for Pixuvri should be granted by the ...
...  A new look at the three most highly regarded ... of its kind to consider long-term cost and quality ... prostatectomy surgery and brachytherapy to be less expensive and ... the treatment of prostate cancer . ...
Cached Medicine Technology:European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 2European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 3European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 4European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 5Prostate Cancer Treatment Options Go Head-to-Head 2Prostate Cancer Treatment Options Go Head-to-Head 3
MDI will work with your facility to determine the best interim lab to fit your needs and your site....
... large number of mobile, modular and transportable ... fleet. The labs are typically leased to ... The Cath Lab Leasing Company allows hospitals ... upgrading existing equipment, initiating a new service ...
... PowerSuite holmium laser combines excellent cutting, ... virtually bloodless procedures. It is also ... gall bladder stones of all compositions, ... tool. Because its laser light is ...
... technology has allowed for perfecting mini-invasive endoscopic ... various pathologies with a considerable social impact. ... reducing the post-operatory times and represents a ... in all hospital structures.,DEKAs family of Nd:YAG ...
Medicine Products: