Navigation Links
Targeted agent shows promise in biliary cancer study
Date:4/20/2009

ition to Ohio State, study sites included the University of North Carolina, Vanderbilt University and Emory University.

The patients, with an average age of 56 years, had advanced (metastatic) biliary cancer.

By the trial's end, one patient had a complete response to the treatment (the tumor shrank until it was undetectable), two patients had partial tumor shrinkage and 17 patients showed no further growth in tumor size; that is, they had stable disease which often was durable.

A preliminary analysis of the study shows that patients experienced no cancer progression for 5.4 months on average, a time almost double what would typically be expected with therapy in biliary cancer. This is despite the fact that 40 percent of patients had one prior therapy before receiving AZD6244. A more final analysis of the study is underway.

Patients who lacked a target protein called pERK did not seem to respond to the drug, suggesting that the drug may not work if the protein is missing in the cancer cells. "This is an important finding, as it suggests that we may be able to identify patients who may not respond to the drug in the future," he adds.


'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted Treatments Show Mettle Against Advanced Cancers
2. UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
3. Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign
4. M. D. Anderson Cancer Center Acquires Leksell Gamma Knife Perfexion for Targeted Brain Lesion Treatments
5. Cancer Researcher Dan Von Hoff, M.D. Advocates for "Context of Vulnerability," A Powerful New Paradigm for Targeted Drug Development
6. Pearly Penile Papule Patients Can Successfully Be Treated with Targeted CO2 Technology at La Jolla Cosmetic Surgery Centre
7. Targeted nanospheres find, penetrate, then fuel burning of melanoma
8. Health Integrated Achieves NCQA Full Accreditation for Its Synergy Targeted Population Management(TM) Program
9. Targeted Prostate Cancer Biopsy and Cancer Treatment Earns Acceptance From Nations Top Prostate Specialists
10. Anthem Blue Cross and Blue Shield Introduces SmartSense, Price-Conscious Plans Targeted at the Uninsured
11. MaxCyte to Present Targeted Cancer Immunotherapy Product at 50th Annual Meeting of the American Society of Hematology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 (HealthDay News) -- It can happen in an instant: ... or computer monitor and gets critically injured when the furniture ... child should look around their homes and imagine what could ... it is better than it becoming a reality," Dr. Alex ... in a college news release. Between 2009 and 2011, ...
(Date:7/30/2014)... SF Cable, distributor of the highest quality ... the internet with guaranteed customer satisfaction announces the availability ... colors. These lightning cords are MFI certified to meet ... SF Cable Lightning to USB Cables feature ... charging and syncing. Compatible with the iPhone 5S/5C/5 plus ...
(Date:7/30/2014)... New York, New York (PRWEB) July 30, 2014 ... died from uncontrollable brain bleeding has filed a Xarelto ... caused by the blood thinner, Bernstein Liebhard LLP reports. ... District Court for the District of Vermont on July ... 10 days when he suffered an irreversible brain bleed ...
(Date:7/30/2014)... Visitors to our region recognize how special it ... protection. Bob Kiesendahl, one of the owners of Woodloch ... Conservancy for donations collected through participation in the Green ... fast, as visitors welcome the opportunity to invest in ... The Kiesendahl family has owned Woodloch Resort for multiple ...
(Date:7/30/2014)... 2014 (HealthDay News) -- Some obese people have a ... centers in their brains when they see food, researchers ... mutation triggers feelings of pleasure and gratification at the ... strategies designed to prevent overeating, the scientists suggested. ... is typically caused by a combination of overeating, ...
Breaking Medicine News(10 mins):Health News:Tip-Over Furniture Can Kill Kids 2Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 3Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:Gene Mutation May Make Food More Tempting 2
... Healthcare Pharmacy, one of,the nation,s largest independent specialty pharmacy ... Companies for 2008." This is the fourth,consecutive year that ... "We are pleased by this recognition," said Mark ... employees we have experienced,continued growth within our industry." , ...
... in the 12th January issue of Archives of ... blood pressure and outdoor temperature in a large sample ... that, during periods of extreme temperatures, careful monitoring of ... the consequences of blood pressure variations in the elderly". ...
... National Lung Cancer Partnership is pleased to announce I-Ching ... of the 2009 Career Development Award. , The $80,000 ... to develop their careers in lung cancer research. ... a protein that binds to specific parts of DNA and ...
... To increase access to,healthcare services and improve health outcomes ... (ICTPH) has partnered with the, University of Pennsylvania, School ... of nurse-managed Rural Micro Health Centres (RMHC) in Tamil,Nadu, ... stage of the partnership, which was signed in January,and ...
... kids from birth to age 21 , , FRIDAY, Jan. 16 ... study that aims to track tens of thousands of children ... at understanding of how genes and environment interact to affect ... Congress in 2000, is expected to uncover important health information ...
... 16 It,s no secret that the,economic landscape ... eat. But, are you,willing to sacrifice your well-being ... other consumers in a recent nationwide study conducted ... convenient and,all-natural snacks. There are many healthy snacks ...
Cached Medicine News:Health News:Seasonal variation in blood pressure 2Health News:ICTPH Partners With University of Pennsylvania, School of Nursing to Enhance Rural Health 2Health News:ICTPH Partners With University of Pennsylvania, School of Nursing to Enhance Rural Health 3Health News:National Childrens Study Begins Recruiting 2Health News:Americans Continue Eating Nutritious and Convenient Snacks Despite Tough Economic Times 2Health News:Americans Continue Eating Nutritious and Convenient Snacks Despite Tough Economic Times 3
(Date:7/30/2014)... PITTSBURGH , July 30, 2014   ... Markets Groups Inc.: OTC Pink: UPZS), a Delaware ... a distribution agreement with Larasan Pharmaceutical Corporation ("Larasan"), a ... products.  According to the agreement, US-based Larasan will ... gourmet 6" frozen pizza through Larasan,s vast distribution ...
(Date:7/30/2014)... and PARIS , July 30, ... ) and Sanofi (EURONEXT: SAN and NYSE: ... ODYSSEY trials of alirocumab in people with hypercholesterolemia met ... from baseline in low-density lipoprotein cholesterol (LDL-C) at 24 ... an investigational monoclonal antibody targeting PCSK9 (proprotein convertase subtilisin/kexin ...
(Date:7/30/2014)... PHILADELPHIA , July 30, 2014  Packaging Coordinators, ... a definitive agreement to acquire Penn Pharmaceutical Services Limited ... Wales in the United Kingdom ... New Hope, Pennsylvania and Tokyo ... manufacturing services, including Clinical and Commercial dosage form manufacturing, ...
Breaking Medicine Technology:Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 2Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 3Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 4Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 5Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 6Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 7Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 8PCI Announces Definitive Agreement to Acquire Penn Pharma 2PCI Announces Definitive Agreement to Acquire Penn Pharma 3PCI Announces Definitive Agreement to Acquire Penn Pharma 4PCI Announces Definitive Agreement to Acquire Penn Pharma 5
... /PRNewswire-Asia/ -- China Kanghui Holdings (NYSE: KH ) ... marketer of orthopedic implants in China, today announced that the ... August 16, 2011, before the market opens. Kanghui ... August 16, 2011 to discuss second quarter results and answer ...
... ATLANTA, July 28, 2011 Data presented this week at ... many people have low vitamin D levels and that testing ... to published data from the Third National Health and Nutrition ... only 23 percent of Americans have vitamin D levels over ...
Cached Medicine Technology:China Kanghui Holdings to Report Second Quarter 2011 Financial Results on August 16, 2011 2Data Presented at American Association for Clinical Chemistry Meeting Show Many Americans May Have Low Vitamin D Levels 2Data Presented at American Association for Clinical Chemistry Meeting Show Many Americans May Have Low Vitamin D Levels 3
... The new SureCut M3500 Radial Microtome has ... is marvelous, and a range of functions and ... users. Based on years of experience and ... innovative design the SureCut M3500 Microtome will be ...
Spare fuse set...
Clock oil, 6 grams net...
Honing compound for knife sharpening, 6 grams net...
Medicine Products: