Navigation Links
Targeted agent shows promise in biliary cancer study
Date:4/20/2009

COLUMBUS, Ohio An experimental agent has shown promising results in people with advanced biliary cancer, according to a multi-institutional clinical trial led by cancer researchers at the Ohio State University.

The agent, known as AZD6244 (ARRY-142886), blocks certain enzymes that cancer cells need to proliferate and survive.

About 100,000 patients are diagnosed with biliary cancer worldwide every year, representing 15-20 percent of all liver cancer cases. Most patients present at later stages of the disease, which has a universally poor outcome.

The findings of the 28-patient, phase II study will be reported April 20 at the annual meeting of the American Association for Cancer Research in Denver, Colorado.

"This is a malignancy for which there is no standard of care," says the study's principal investigator Dr. Tanios Bekaii-Saab, assistant professor of medicine and pharmacology, and a medical oncologist who specializes in gastrointestinal cancers at Ohio State's Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute.

"And while it is a small study, it provides a strong rational for developing this agent further in larger trials either alone or in combination with other drugs, with the hope that we can establish a new standard of care for biliary cancers in the near future."

Bekaii-Saab noted that the average progression-free survival achieved by patients in the study was one of the highest reported in the literature for this malignancy with many patients gaining weight in a disease that is typically associated with significant weight loss. The drug, which is administered orally, seems to be well tolerated with mild toxicities.

The agent belongs to a class of drugs called protein kinase inhibitors. This particular drug targets a protein kinase called MEK 1/2, which is part of a chemical pathway that is often damaged in many biliary cancer cases, Bekaii-Saab says.

In add
'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted Treatments Show Mettle Against Advanced Cancers
2. UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
3. Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign
4. M. D. Anderson Cancer Center Acquires Leksell Gamma Knife Perfexion for Targeted Brain Lesion Treatments
5. Cancer Researcher Dan Von Hoff, M.D. Advocates for "Context of Vulnerability," A Powerful New Paradigm for Targeted Drug Development
6. Pearly Penile Papule Patients Can Successfully Be Treated with Targeted CO2 Technology at La Jolla Cosmetic Surgery Centre
7. Targeted nanospheres find, penetrate, then fuel burning of melanoma
8. Health Integrated Achieves NCQA Full Accreditation for Its Synergy Targeted Population Management(TM) Program
9. Targeted Prostate Cancer Biopsy and Cancer Treatment Earns Acceptance From Nations Top Prostate Specialists
10. Anthem Blue Cross and Blue Shield Introduces SmartSense, Price-Conscious Plans Targeted at the Uninsured
11. MaxCyte to Present Targeted Cancer Immunotherapy Product at 50th Annual Meeting of the American Society of Hematology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... It’s a pattern that won’t relent anytime ... on this planet, cyber scammers will immediately be thinking ... their own personal gain. And on April 30, ... issued an alert titled “Nepal Earthquake Disaster Email Scams,” ... earthquake in Nepal. The scam emails may contain links ...
(Date:5/2/2015)... “ Peachtree Audio ” was featured on NewsWatch ... the latest and coolest technology products available to consumers. ... NewsWatch, conducted the review and shared with viewers how ... is an important part of people’s lives – and ... royal treatment. Peachtree Audio does just that with high-end ...
(Date:5/2/2015)... 2015 Kare Visits LLC. launched in Chicago ... caregivers. Kare Visits offers relief for caregivers by visiting ... According to the Caregiver Action Network, eight in ... 20 hours a week caring for an elderly or disabled ... hire a nurse, a caregiver is now empowered to schedule ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 ZoomCare, the ... has submitted plans to offer its new healthcare insurance ... The ZOOM+ Personal Health Insurance System is the nation’s ... to enhance human performance. ZOOM+ Personal Health Insurance was ... delivery system that are subject to review and regulation ...
(Date:5/1/2015)... 2015 IDLife LLC, a health and ... announce the addition of its newest partner and fitness ... long athlete, growing up in gymnastics and competitive diving, ... becoming a personal trainer and helping others achieve their ... several TV shows highlighting her stunning physique and unique ...
Breaking Medicine News(10 mins):Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:IDLife LLC Announces New Partnership with Fitness Celebrity, Jen Widerstrom 2
... NEW YORK, Jan. 7 Crystal Research Associates, ... Informational Overview(R),(EIO(R)) on Unilife Medical Solutions Limited (UNI-ASX). ... www.crystalra.com and www.unilife.com . , ... or "the Company") develops,and supplies innovative safety medical ...
... can be healthy and hazardous for seniors, experts ... head south each winter to escape the cold often feel ... are adjustments to be made to make sure these "snowbirds" ... more time socializing, boosts mood and well being for 65-plus ...
... Jan. 7 AGA Medical Corporation ("AGA,Medical") announced ... Ministry,of Health, Labour and Welfare (MHLW) for its ... transcatheter occlusion device used for the,non-surgical closure of ... heart defect that occurs when a blood vessel ...
... Jan. 7 Pearson VUE, the computer-based testing ... signed an agreement with the National Association of ... test delivery provider of the computer-based Foreign Pharmacy ... these exams will be delivered throughout the secure ...
... FL, Jan. 7 /PRNewswire-FirstCall/ - Hard to Treat Diseases ... announce that it has identified a cosmetics company as ... in E Europe (Serbia) is engaged in online sales ... skin and lip balm. It has a wide variety ...
... REDWOOD CITY, Calif., Jan. 7 Ingenuity Systems, ... researchers, today,announced the release of IPA 7 with ... of a series of powerful biological filters and ... experimental results and fine-,tune scientific hypotheses in relation ...
Cached Medicine News:Health News:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Unilife Medical Solutions Limited 2Health News:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Unilife Medical Solutions Limited 3Health News:'Snowbirds' Beware the Climate Changes 2Health News:'Snowbirds' Beware the Climate Changes 3Health News:AGA Medical Receives Japanese Approval for AMPLATZER(R) Duct Occluder 2Health News:AGA Medical Receives Japanese Approval for AMPLATZER(R) Duct Occluder 3Health News:NABP Expanding Computer-Based Test Delivery to Include Foreign Pharmacy Graduate Equivalency Examination(R) 2Health News:Hard To Treat Diseases (HTDS) Set To Acquire Cosmetics Company 2Health News:IPA 7 Introduces Unique Contextual Search and Analysis Capabilities 2
(Date:5/1/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vzcw2v/americas_clinical ) has ... Market by Product, by End-Users - Forecast to 2019" ... Analyzers market is estimated to grow at a CAGR of ... Canada , Mexico , ... are covered in this report. The Americas is ...
(Date:5/1/2015)... -- Portal Instruments, Inc., an emerging leader in the development ... Robert Langer, Sc. D., MIT Institute Professor, and ... have joined the company,s Scientific Advisory Board. ... Professor Robert Langer and Professor Peter ... Anquetil , Chief Executive Officer of Portal Instruments. "We ...
(Date:5/1/2015)... May 1, 2015  CytRx Corporation (CYTR), a ... today reported financial results for the three months ... of recent accomplishments and upcoming milestones for its ... milestones in the early months of 2015, including ... trial of aldoxorubicin in patients with soft tissue ...
Breaking Medicine Technology:Americas Clinical Chemistry Analyzer (Semi-Automated Clinical Chemistry and Fully-Automated Clinical Chemistry) Market - Forecast to 2019 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 3Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 4CytRx Reports First Quarter 2015 Financial Results 2CytRx Reports First Quarter 2015 Financial Results 3CytRx Reports First Quarter 2015 Financial Results 4CytRx Reports First Quarter 2015 Financial Results 5CytRx Reports First Quarter 2015 Financial Results 6CytRx Reports First Quarter 2015 Financial Results 7CytRx Reports First Quarter 2015 Financial Results 8CytRx Reports First Quarter 2015 Financial Results 9CytRx Reports First Quarter 2015 Financial Results 10CytRx Reports First Quarter 2015 Financial Results 11
... 17, 2012  PLC Systems Inc. (OTC: PLCSF), a company ... an article summarizing the results from its U.S. pilot ... December 26, 2011 International Journal of Cardiology , ... Adult Congenital Heart Disease. The results from this ...
...  Palatin Technologies, Inc. (NYSE Amex: PTN ) ... $1.1 million of non-dilutive funding through the New Jersey ... sold both New Jersey net operating losses and research ... Last year, Palatin Technologies received approximately $637,000 under this ...
Cached Medicine Technology:Results From Pilot Trial of PLC's RenalGuard® Published in International Journal of Cardiology 2Results From Pilot Trial of PLC's RenalGuard® Published in International Journal of Cardiology 3
SPIRAL-FLEX® Oral Precut Reinforced Tubes...
Pre-Loaded with a Stylet., ,Available Cuffed or Uncuffed, pre-loaded with a stylet to facilitate quick intubations....
... cuff., ,Sheridan Endotracheal Tubes offer the ... level of tactile feedback from pilot balloon ... soften at body temperature , Smooth tube ... trauma during intubation , Two distinct cuff ...
Adult (ICU) Tracheal Tubes with Micro-thin-walled cuffs....
Medicine Products: