Navigation Links
Targeted agent selumetinib shows promise in biliary cancer

COLUMBUS, Ohio The experimental agent selumetinib has shown promising results in people with advanced biliary cancer, according to a multi-institutional clinical trial led by cancer researchers at The Ohio State University.

Selumetinib, also known as AZD6244 (ARRY-142886), blocks a protein called MEK, which cancer cells need to proliferate and survive.

Biliary cancer is a malignancy of cells lining the bile ducts and gall bladder. About 100,000 patients are diagnosed annually worldwide with the disease, representing 15-20 percent of all liver-cancer cases. Most patients present at later stages of the disease, which has a universally poor outcome.

The findings of this 28-patient, multi-institutional phase II study are reported online in the Journal of Clinical Oncology.

"This malignancy has no good standard of care," says principal investigator Dr. Tanios Bekaii-Saab, medical director of gastrointestinal oncology and a medical oncologist at Ohio State's Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute.

"Our study provides a strong rationale for developing this agent further in larger trials, probably in combination with other drugs, which we hope will enable us to establish a new standard of care for biliary cancers in the near future," adds Bekaii-Saab.

In addition to Ohio State, trial participants included the University of North Carolina, Vanderbilt University and Emory University.

Selumetinib belongs to a class of drugs called protein-kinase inhibitors. The agent selectively inhibits the protein kinases MEK1 and MEK2. It is part of a signaling pathway that is often damaged in biliary cancer cells. The trial showed the following:

  • One patient responded completely the tumor shrunk until it was undetectable and two patients showed partial tumor shrinkage;
  • In 17 patients, the tumor stopped growing. This condition of stable disease lasted up to 16 weeks in the majority of cases;
  • Patients experienced no cancer progression for a promising 3.7 months on average, despite the fact that nearly 40 percent of patients had prior therapy before receiving selumetinib (such tumors tend to be more resistant to treatment);
  • Patients taking the drug regained weight about 9 pounds on average. This included patients with tumors that may not have responded to the drug, Bekaii-Saab notes.

Patients who lacked a target protein called pERK did not seem to respond to the drug, suggesting that the drug may not work if the protein is missing in the cancer cells. "This finding suggests that in the future we may be able to identify which patients are most likely to respond to the drug," he adds.


Contact: Darrell E. Ward
Ohio State University Medical Center

Related medicine news :

1. Primary care targeted for suicide prevention efforts
2. Modern targeted drug plus old malaria pill serve a 1-2 punch in advanced cancer patients
3. Scientists devise targeted therapy strategy for rare form of childhood cancer
4. Mass. General study reveals how lung cancers evolve in response to targeted treatment
5. New targeted drug helps smokers stub it out
6. Ohio State study: Targeted ovarian cancer therapy not cost-effective
7. VCU Massey first to combine targeted agents to kill multiple myeloma cells
8. IU Personalized Medicine Institute to develop targeted and individualized treatments
9. Targeted particle fools brains guardian to reach tumors
10. PET scans may allow early prediction of response to targeted therapy of thyroid cancer
11. UMMS and Lundbeck to explore potential targeted therapy for Huntingtons disease
Post Your Comments:
(Date:12/1/2015)... , ... December 01, 2015 , ... ... it has been selected as a finalist in this year’s Fierce Innovation Awards: ... Next IT Healthcare was recognized as a finalist in the category of Digital ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... and clinical solutions for the care management and population health arenas, is pleased ... providing clinical and cost containment services, has successfully implemented the ACUITY Complete Care™ ...
(Date:12/1/2015)... Atlanta, GA (PRWEB) , ... December 01, 2015 ... ... manufacturing, supports SACC-GA and SACC-USA through membership and leadership since 2008. ... and Chair for SACC-USA . Gary has spent a significant amount of ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. ... a Modern Man for 2015. , Angeleno Magazine is a division of ... Established in 1994, Modern Luxury includes more than 50 magazine titles across 15 ...
(Date:11/30/2015)... ... November 30, 2015 , ... Third Molar SEO ... it has officially launched a sleek, mobile-ready and user-centric redesigned website. , Vivek ... website clearly outlines the benefits that its SEO services provide to dentists and ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... TELTOW, Germany , December 1, 2015 ... a leading global manufacturer of eye and gaze tracking ... included SMI remote eye trackers as a component of ... assess concussions, eye sight, and medical and performance issues ... is part of SMI,s mass-market-ready eye tracking platform, which ...
(Date:12/1/2015)... ENGLEWOOD, Colo. , Dec. 1, 2015 ... the New York Stock Exchange has established January 5, 2016 ... to its stockholders of the shares of Common Stock ... one (1) share of Aytu common stock for every ... of the record date, December 1, 2015. The distribution date ...
(Date:12/1/2015)... Research and Markets ( ) ... Global Enteric Disease Testing Market: Campylobacter, Cryptosporidium, E. ... Germany, Italy, Japan, Spain, UK, US" report ... . --> Japan ... based on a combination of primary and secondary ...
Breaking Medicine Technology: