Navigation Links
Targeted agent blocked growth of deadly brain cancer in preclinical studies
Date:3/30/2010

es, cyclin-dependent kinases 4 and 6 (cdk4/6), that drive cell division. "In normal cells, these kinases are kept under exquisite control by a gene known as p16," says Waldman. "But in glioblastoma, and other cancers, p16 is frequently deleted, and these two kinases are uncontrollably activated, which drives the cell to divide and form cancer."

The agent, however, does not work if the cancer is missing expression of a tumor suppressor protein known as retinoblastoma (Rb) because Rb is needed to control growth in these cells even if cdk4/6 are inhibited. A test to determine if RB is present is already being used to screen patients for use of PD-0332991 in the ongoing clinical trials.

A research team at Georgetown led by Waldman, conducted laboratory studies on 21 different cell lines derived from the tumors of patients with glioblastoma. They tested PD-0332991 at various concentrations to see if it could stop growth of the cancer cells, and found it to be effective in all 16 cell lines with a functioning Rb gene, but it did not work in 5 cell lines missing Rb. "The agent was very potent in stopping cancer growth, but it was also quite clean in that it only seemed to inhibit the two molecules it targeted, and no other," says Waldman. "Most drugs are dirtier than that they hit multiple unintended targets."

What intrigues Waldman, he says, is that no one has discovered what the "normal" function for cdk4/6 is. "Mice lacking either cdk4 or cdk6 grow up to be relatively healthy, so it may be that these kinases are really only important for cancer growth," Waldman says. "That would be an exciting development, if true, but no one knows yet."

James led a team of scientists at UCSF that implanted three different kinds of human glioblastoma directly into the brains of mice, and then they treated them with PD-0332991. They discovered first that the agent effectively reached intracranial tumors "and it wasn't known beforehand that it would, so this was v
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
2. Gene-Targeted Cancer Fix Could Be a Breakthrough
3. Targeted delivery of losartan reduces liver inflammation and scarring
4. Targeted prevention stopped spread of H1N1 at Alabama boys camp
5. Human Touch Introduces New CirQlation™ Elite Foot & Calf Massager Providing Ultimate Targeted Relief for Tired Feet and Calves
6. Middle Schoolers Identify Violent Content in Youth-Targeted Entertainment as a Strong Influence in Causing Youth Violence
7. Targeted therapy prolongs life in patients with HER2-positive breast cancer
8. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
9. Targeted breast ultrasound can reduce biopsies for women under 40
10. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
11. Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... (PRWEB) September 19, 2014 Famous Vancouver ... announced that it has now become a one-stop-solution for ... and businesses in Vancouver. The company has achieved this ... services to its customers. While there are many companies ... to have a single vendor who can offer all ...
(Date:9/19/2014)... Recently, Top10BestSEOHosting.com has compared many professional web ... Hosting and Bluehost are the best VPS suppliers ... most people, VPS (Virtual Private Server) is the ... many servers, each of which has the appearance ... computer,” the manager of Top10BestSEOHosting.com says. , ...
(Date:9/19/2014)... September 19, 2014 Top 10 ... recently announced that HostGator.com, GoDaddy and Bluehost are ... These companies are the most recommended suppliers for ... Europe to buy high quality Linux hosting (including ... ) is one of many top hosting companies ...
(Date:9/19/2014)... 19, 2014 Ticket Down has ... for her 2015 “Honeymoon” Tour. This popular ticket reseller ... savings at the checkout. , Ariana Grande 2015 Honeymoon Tour ... Center) , Feb. 28, 2015: Milwaukee, WI (BMO Harris Bradley ... Center) , March 03, 2015: Chicago, IL (Allstate Arena) , ...
(Date:9/19/2014)... York University researchers say a simple test that ... heightened risk for developing Alzheimer,s disease in a ... signs of dementia., Faculty of Health Professor Lauren ... the study asked the participants to complete four ... screen laptop computers. The test aimed at detecting ...
Breaking Medicine News(10 mins):Health News:Pro Ace Now Provides Heating, Air Conditioning, Plumbing & Electrical Services under One Roof 2Health News:Top10BestSEOHosting.com: JustHost is One of the Best VPS Suppliers in 2014 2Health News:Top10BestSEOHosting.com Announces Great Linux Web Hosting Suppliers In 2014 2Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 2Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 3Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 4Health News:Simple test can help detect Alzheimer's before dementia signs show: York U study 2
... ABAX ), a medical products company manufacturing point-of-care blood,analysis ... 2008. , , Highlights for the third quarter ... $27.0 million, up 5% over last year,s comparable quarter., ... over last year,s, comparable quarter., ...
... underlying trait, but connection is vague, study says , , ... doesn,t decrease a woman,s risk of preterm birth, according ... a link. , As a result of those earlier ... pregnant women undergo dental "deep cleaning" (scaling and root ...
... and PALO ALTO, Calif., Jan. 29 ,Diagnosoft, Inc., ... that assists in diagnosis, staging and therapeutic monitoring ... $4 million in Series B,financing led by Technology ... intends to use the new capital to support ...
... 29 Mylan Inc. (Nasdaq: MYL ) today ... issuance, the company has declared its quarterly dividend of $16.25 ... and a liquidation preference of $1,000.00 per share) payable on ... as of Feb. 1, 2009.Mylan Inc., which provides products to ...
... Meditation Center of Los Angeles will present a program featuring ... an ancient practice of physical fitness, which has been used ... youthfulness in the body. The Level 1 & 2 ... Center for the Arts in Eagle Rock.The healing Taoist practice ...
... On February 19, 2009 at Noon CT, compliance and ... and Catholic Healthcare West will be discussing how companies ... stagnant or declining budgets. They will be participating ... and Ethics, Five Leaders, Five Industries, Ideas for Your ...
Cached Medicine News:Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 2Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 3Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 4Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 5Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 6Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 7Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 8Health News:Abaxis Reports Financial Performance for the Third Quarter of Fiscal 2009 9Health News:Gum Disease Treatment Doesn't Cut Preterm Birth Risk 2Health News:Diagnosoft(R) Secures $4 Million in Financing and Appoints a New President and CEO 2Health News:Diagnosoft(R) Secures $4 Million in Financing and Appoints a New President and CEO 3Health News:Diagnosoft(R) Secures $4 Million in Financing and Appoints a New President and CEO 4Health News:World-renowned Instructor of the Healing Practice of Qigong to Teach in Los Angeles Mar. 7 & 8 2Health News:Five Leaders From Five Industries to Tackle Concerns Over the Economy and Its Impact on Compliance and Ethics During Society of Corporate Compliance and Ethics and Health Care Compliance Association Audio/Web Conference 2
(Date:9/19/2014)... Sept. 19, 2014  Over 200 runners participated in ... Benefit the Radiation Oncology Institute (ROI), hosted by Radiation ... Gate Park in San Francisco.  "Donations ... CEO of Radiation Business Solutions, "but at this ... over $70,000 for the ROI this year. This surpasses ...
(Date:9/19/2014)... 19, 2014  PCI is pleased to announce ... is a leading provider of Clinical Trial Services ... Wales in the ... expands PCI,s presence in the UK/EU to support ... packaging, storage and distribution capacity, as well as ...
(Date:9/18/2014)... 18, 2014  LABSCO, the leading specialty ... products to hospitals, physician office laboratories and ... distributorship agreement with Sysmex America.  This agreement ... including the Sysmex XS-1000 i ™, Sysmex ... XN-Series Automated Hematology Analyzers. The ...
Breaking Medicine Technology:Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3PCI Announces Acquisition Of Biotec 2PCI Announces Acquisition Of Biotec 3PCI Announces Acquisition Of Biotec 4PCI Announces Acquisition Of Biotec 5PCI Announces Acquisition Of Biotec 6LABSCO Renews Sysmex Distributorship Agreement 2LABSCO Renews Sysmex Distributorship Agreement 3
... Approximately ninety-one percent of dentists say patients complaining about dry ... survey conducted by the Academy of General Dentistry (AGD). ... decrease in salivary function. It affects approximately one in ... risk for tooth decay. During the Academy of General Dentistry,s ...
... Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced that ... July 9, 2009 at 8:00 am EDT (5:00 am PDT). ... investigator of the trial will discuss results of the Company,s ... the Company,s plans for further development and related matters. ...
Cached Medicine Technology:Dry Mouth Linked to Prescription and Over the Counter Drugs 2Dry Mouth Linked to Prescription and Over the Counter Drugs 3Rigel to Host Conference Call to Discuss Results of Its Phase 2b TASKi2 Clinical Trial of R788 in Rheumatoid Arthritis 2
As part of a complete all-in-one system, Sentry LabelBand securely seals inexpensive paper labels inside a clear, adhesive shield. LabelBand provides easy and accurate bar code scanning and protectio...
... PDCs computer-generated Thermal Printing Wristbands and ... direct thermal and thermal transfer printers. ... activate a heat-sensitive thermal coating under ... printers use heat to transfer highly ...
... for use in settings, such ... where you may need a ... easy to apply but very ... width is increased to 1 ...
A unique and cost effective one-piece adhesive closure patient bracelet with a tamper- resistant feature that has been designed for patient comfort, caregiver productivity, and long term durability....
Medicine Products: