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Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
Date:6/11/2008

); protein kinase C (PKC); PKC-B; purine nucleoside phosphorylase (PNP); ras; R1 mRNA; R2 mRNA; Raf/B-Raf; Rad51; RET; ribonucleotide reductase (RNR); ribonucleotide reductase M2 polypeptide (RRM2); Ron; SH2-containing protein-tyrosine phosphatase 1 (SHP-1); signal transducer and activator of transcription 3 (STAT3); SLAM family member 7 (SLAMF7); somatostatin receptors (SSTr); somatotropin release inhibiting factor (SRIF) receptor (SRIFr); sphingosine kinase (SPHK); spingomyelin synthase; Src pathway; stromal derived factor 1 (SDF-1); superoxide dismutase 1, soluble (SOD1); survivin; telomerase reverse transcriptase (TERT, hTERT); telomerase; tenascin-C (TN-C); TGF-beta; TGF- beta2; thioredoxin-1 (trx-1); tie-2; toll-like receptor 7 (TLr7); TLr9; transferrin; transforming growth factor beta receptor I (TGFBr1); TGFbeta; tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 1 (TRAIL-r1); TRAIL-r2; tumor suppressor candidate 2 (TUSC2), FUS1; tumor- associated glycoprotein 72 (TAG-72); vitamin D receptor (VDr); Von Willebrand factor; X-linked inhibitor of apoptosis protein (XIAP); etc. Hundreds of other molecular targets are in preclinical development.

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