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Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
Date:6/11/2008

shock proteins (Hsp)

10 drugs targeting various cyclin-dependent kinases (Cdk)

10 agents targeting c-Met

10 agents targeting IGF/IGFr

10 agents targeting FLT-3

9 agents targeting c-Kit

Additional targets include 20S proteasome; polyamine; 5T4 oncofetal antigen; a disintegrin and metalloproteinase domain 17 (ADAM17), TACE; acidic fibroblast growth factor (aFGF); activin receptor IIA (ActrIIA); adenosine deaminase; adenosine monophosphate (AMP); alpha5beta1 integrin; alphanubeta3 integrin; alphanubeta5 integrin; alpha-fetoprotein (AFP) receptor (RECAF); Akt; anaplastic lymphoma kinase (ALK); androgen receptor (Ar); angiopoietin-1; angiopoietin-2; APEX; ATP synthase [alpha] subunit; axl; Bap31; Bcl-xL; Bcl-2; bcr-abl/abl (including mutated forms); B-FN (ED-B fibronectin); carboxyanhydrase IX (CA IX); carcinoembryonic antigen (CEA); cathepsin K (CTSK); C-C chemokine receptor 4 (CCr4); CD105 (endoglin); CD13; CD19; CD20; CD22; CD25; CD3; CD30; CD33; CD38; CD4; CD40; CD55; CD56; CD70; CD74; CD80; CD95 (fas); CD137 (TNFrSF9); centromere-associated protein E (CENP-E); cGMP- PDE; checkpoint 1 (Chk1); chemokine (C-X-C motif) receptor 4 (CXCr4); Chk2; chondroitin sulfate proteoglycan 4 (CSPG4); C-Jun N-terminal kinase (JNK); c- Myb; c-Myc; colony stimulating factor 1 receptor (CSF1r); CTNNB (beta catenin); cyclin E; cyclin-dependent kinase inhibitor 1A (CDKN1A); cytochrome P450 1B1 (CYP1B1); cytotoxic T lymphocyte-associated antigen 4 (CTLA4); dihydrofolate reductase (DHFR); DT-diaphorase (DTD); E2F; E2F1; endocytic lectin receptors (EELr); endothelin A (ETA) receptor (ETAr); ephrin B4 (EphB4); epithelial cell adhesion molecule (EpCam); estrogen receptor-alpha (Er-alpha); eukaryotic translation initiation factor 4E (EIF4E); exonuclease III; farnesyl transferase (FTase); fibroblast growth factor 2 (FGF-2); FGFr; focal adhesion kinase (FAK); folate receptor (FOLr); FOLr1; galectin 3 (GAL3) receptor; gastrin 17 (G17); GD2; GD3; glioma-associa
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SOURCE New Medicine, Inc.
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