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Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
Date:6/11/2008

New Medicine's Oncology KnowledgeBASE (nm/OK) tracks the development and use of patient and tumor assessment methodologies that represent one of the

most unique opportunities in the oncology field

LAGUNA NIGUEL, Calif., June 11 /PRNewswire/ -- Drug development in oncology is at the threshold of a new era that may finally fulfill the promise of cancer becoming a chronic disease. It is becoming apparent that in order to successfully treat patients with cancer it is necessary to accurately profile their disease and closely and continuously monitor its development. Coupling the use of targeted anticancer agents with patient selection and monitoring using highly specific in vitro tests and/or noninvasive imaging approaches is creating a unique and powerful method for the effective treatment of cancer.

New Medicine's Oncology KnowledgeBASE (nm/OK) that has anticipated this trend is a unique resource of every aspect of patient assessment to customize cancer treatment. A unique functionality of nm/OK allows users to specifically retrieve information regarding diagnostic/prognostic approaches by developer and cancer indication; target assessment (overexpression, amplification, mutation, methylation status) by drug, marker, and clinical trial protocol; and biomarkers for clinical trial surrogate endpoints, among others.

There are over 1,000 molecular targets linked to some aspect of neoplasia currently in preclinical or clinical development or on the market. Among the approximately 500 novel molecularly targeted agents that have been evaluated in clinical trials (multitargeted agents may appear in several groups) are:

41 agents targeting the vascular endothelial growth factor (VEGF) pathway

18 agents targeting the ErBb family (EGFr, HEr2, etc.)

13 agents targeting the Aurora kinase family

11 histone deacetylase inhibitors (HDAC)

13 agents targeting PDGF/PDGFr

11 agents targeting various heat
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SOURCE New Medicine, Inc.
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