Navigation Links
Tamoxifen-resistant breast cancer reversed when drug paired with anti-malaria agent
Date:6/12/2014

WASHINGTON The inexpensive anti-malarial drug hydroxychloroquine (HCQ) reverses resistance to tamoxifen, a widely used breast cancer drug, in mice.

In the June 15 issue of Clinical Cancer Research, investigators from Georgetown Lombardi Comprehensive Cancer Center say adding HCQ to tamoxifen could provide a new treatment option for some women with advanced, postmenopausal estrogen receptor-positive (ER+) breast cancer. The ER+ subtype accounts for an estimated 70 percent of all breast cancers. While many of these women are treated with tamoxifen, which blocks estrogen from fueling the tumor, 50 percent of these cancers will either not respond or will become resistant to tamoxifen over time.

"Tamoxifen resistance when treating breast cancer is a big issue in the clinic, and we believe our findings provide a very promising fix to the problem," says the study's senior investigator, Robert Clarke, PhD, DSc, dean for research at Georgetown University Medical center, and co-director of the breast cancer program at Georgetown Lombardi.

Clarke adds that both drugs are inexpensive, on the market and have a well-defined safety profile.

HCQ was developed to treat malaria, but has since been repurposed as therapy for rheumatoid arthritis and lupus. The study is the first to test HCQ's ability to restore breast cancer cell sensitivity to tamoxifen or to a different anti-estrogen drug known as faslodex.

The research team, led by first author Katherine Cook, PhD, a postdoctoral research fellow in the tumor biology department at Georgetown Lombardi, purposely set out to test HCQ in mice with either tamoxifen or faslodex-resistant human breast cancer cells.

Previous research led by Clarke and Cook found that tamoxifen resistance occurs because a pro-survival pathway is switched on in breast cancer cells. HCQ functions by turning off that very same molecular pathway, Cook says.

The researchers found that t
'/>"/>

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New finding gives clues for overcoming tamoxifen-resistant breast cancer
2. Eliminating the good cholesterol receptor may fight breast cancer
3. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
4. Researchers develop a new cell and animal model of inflammatory breast cancer
5. Scientists uncover multiple faces of deadly breast cancer
6. Depo-Provera Birth Control Might Raise Breast Cancer Risk
7. Routine mammograms may result in significant overdiagnosis of invasive breast cancer
8. Mayo Clinic launches whole genome breast cancer study
9. Breast cancer patients suffer treatment-related side effects long after completing care
10. Teen Drinking May Boost Odds of Precancerous Breast Changes
11. Stress contributes to cognitive declines in women with breast cancer, researcher says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 The Biofeedback ... place March 24-28, 2015 in Rome, Italy and is ... includes workshops on a wide variety of ... well as peak performance training in athletes. The scientific ... the world. , Biofeedback monitoring allows clients to see ...
(Date:12/26/2014)... 26, 2014 Pentec Health, Inc. number ... state of Pennsylvania for 2014. The awards program, created ... of its kind in the country. The program is ... Department of Community and Economic Development, the Pennsylvania State ... the Central Penn Business Journal. , Charlie ...
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 This ... state of the global Sterilizers industry with a focus ... on the market status of the Sterilizers manufacturers and ... companies and individuals interested in the industry. This report ... definition, applications and manufacturing technology. In this part, the ...
(Date:12/25/2014)... New York, New York (PRWEB) December 25, 2014 ... of the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ... Liebhard LLP reports. According to an Order issued in ... November 20th, the Court will convene an open conference ... Federal Building and United States Courthouse in West Palm ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 The short film ... was created in honor of a true 9/11 hero, Welles ... film festivals including the 24 hours of Nuremberg International Short ... Bangladesh. , Actress, screenwriter and director Luciana Lagana ... this film together with her husband, Gregory Graham ...
Breaking Medicine News(10 mins):Health News:Final Workshop Line-up Announced for 18th Annual Biofeedback Conference in Rome, Italy 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3
... , WEDNESDAY, Nov. 16 (HealthDay News) -- One in ... due to side effects caused by the medicine and may be ... is the standard of care for the hormone treatment of male ... published in the Nov. 16 issue of the Annals of ...
... the tolerability of the breast cancer drug tamoxifen in male ... prescribed therapy early because of problems with side effects caused ... paper, published today in the cancer journal Annals of ... cancer patients at their institution who had received tamoxifen for ...
... (ORLANDO) -- Just 30 percent the nation,s state police ... external defibrillators, and of those, nearly 60 percent of ... lifesaving devices on board, according to new research from ... Pennsylvania that will be presented today at the American ...
... developed a new genetic screening tool that will ... patients with melanoma and the unique genetic mutations ... presented at the AACR-NCI-EORTC International Conference: Molecular Targets ... Heinz-Herbert Fiebig, M.D., Ph.D., associate professor of medical ...
... HealthDay Reporter , TUESDAY, Nov. 15 (HealthDay News) -- ... three kiwis just might help, at least according to a small ... pressure levels. Men and women with mildly high blood pressure ... systolic blood pressure levels that were 3.6 millimeters of mercury ...
... four years of problem drinking, a significant decrease in the ... seen. This is the system that regulates such functions as ... corresponding decrease is seen in men. This is the conclusion ... and the Sahlgrenska Academy at the University of Gothenburg, Sweden. ...
Cached Medicine News:Health News:Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer 2Health News:Male breast cancer patients stop taking tamoxifen early because of drug-related side effects 2Health News:Male breast cancer patients stop taking tamoxifen early because of drug-related side effects 3Health News:Panel of melanoma mutations opens door to new treatment possibilities 2Health News:Got High Blood Pressure? Kiwi Fruit May Help 2Health News:Got High Blood Pressure? Kiwi Fruit May Help 3
(Date:12/24/2014)... Mich. , Dec. 24, 2014  Diplomat Pharmacy, ... independent specialty pharmacy, is proud to announce Jennifer ... quality at Diplomat, will take office as the president ... The formal induction ceremony will take place Feb. 28, ... will be held at the Renaissance Center in ...
(Date:12/24/2014)... PuraMed BioScience®, Inc., (OTC Pink: PMBS), a ... healthcare products, announced it received the initial funding to ... headache relief product, for planned distribution to 1,000 medical ... , Washington State , and ... H Advanced headache relief gel formulation completed, PuraMed BioScience ...
(Date:12/24/2014)... 23, 2014 ResMed (NYSE: RMD ) ... against Chinese medical device manufacturer BMC Medical Co., Ltd. ... BMC,s masks listed below infringe ResMed,s patents, and entered an ... in the United States : ... , Willow nasal pillows mask , iVolve full ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... 2011 Watson Pharmaceuticals, Inc. (NYSE: WPI ), ... Company intends to release its second quarter 2011 financial results ... the U.S. financial markets.  The Company will also host a ... July 26, 2011 to discuss its financial results and provide ...
... BRUSSELS, June 30, 2011 UCB and Harvard University ... ceremony that took place in Boston last night in ... Belgium. (Photo: http://photos.prnewswire.com/prnh/20110630/NY28450 ) ... between industry and academia, with Harvard scientists continuing their ...
Cached Medicine Technology:Watson to Host Conference Call and Webcast to Discuss Second Quarter 2011 Earnings 2UCB Launches Research Alliance with Harvard University 2UCB Launches Research Alliance with Harvard University 3
9 mm button end blade. 15 mm long backcutting blade. Angled at 45 degrees. Flat handle. Designated most popular model or size....
10 mm blade, angled left. Flat handle....
4 mm blade. Bayonet. Flat handle....
Double-ended. Blades set at 45 and 90 degrees. Hexagonal handle....
Medicine Products: