Navigation Links
Tall and thin not so great for lung disease
Date:1/23/2013

Tall, thin women face a greater risk of infection with nontuberculous mycobacteria (NTM), cousins of the organism that causes tuberculosis, according to researchers at National Jewish Health. Women with NTM infections also showed a weakened immune response associated with their fat cells, in a paper published in the Jan. 15, 2013, issue of The American Journal of Respiratory and Critical Care.

"Nontuberculous mycobacteria are widespread in the environment, yet only some people develop infections," said Edward Chan, MD, senior author and professor of medicine at National Jewish Health. "These findings help us identify who is at greater risk for the disease, and may point to more effective therapies down the road."

There are dozens of NTM species. Although the organisms can infect skin and other body parts, they most commonly infect the lungs. Lung infections are very difficult to treat, often requiring surgery and years of therapy with powerful intravenous antibiotics. NTM infections can be fatal. Evidence suggests that infections have been rising in recent decades.

NTM species are widespread in water and soil, yet only about five to six people per 100,000 develop NTM infections each year; the incidence is higher in individuals older than 50. An estimated 30,000 to 120,000 people in the US currently have NTM infections. Researchers at National Jewish Health, which sees more NTM infections than any other medical center in the world, tried to figure out why only some exposed patients develop these difficult infections.

Elderly women represent the vast majority of NTM patients, accounting for 85 percent of the patients seen at National Jewish Health during the study, and averaging about 64 years of age. The researchers chose to compare the NTM patients with control subjects at an osteoporosis clinic because these individuals were similar age, race, and gender as the NTM patients.

When compared to the women visiting the osteoporosis clinic, the NTM patients were on average almost two inches taller, had body mass indices almost two points lower and 5.7 pounds less fat on their bodies. The NTM patients also more frequently had concave chests, a condition known as pectus excavatum, and scoliosis, or curvature of the spine.

"Tall, thin women definitely appear to be more susceptible to NTM infections," said Dr. Chan. "They share some characteristics of people with Marfan syndrome. Since Marfan syndrome is caused by a mutation in the fibrillin-1 gene, we plan to look at that gene as a potential source of NTM susceptibility."

In addition to body type, NTM patients also differed in their immune response. Fat cells produce hormones, leptin and adiponectin, known to regulate both weight and immune function. Leptin production generally increases as people grow fatter. It also helps stimulate the immune system to fight infections. Adiponectin, an immunosuppressive hormone, generally decreases as people grow fatter. While these standard relationships held for the control subjects, they broke down for NTM patients with levels of these fat-derived hormones varying only minimally with body fat in NTM patients.

"In addition to body type, NTM patients also appeared to have some dysregulation of their immune response, which could increase their susceptibility to NTM infections," said co-author Michael Iseman, MD, professor of medicine at National Jewish Health.


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Related medicine news :

1. Bullied Children at Greater Risk for Self-Harm, Study Finds
2. Greater numbers of highly educated women are having children, bucking recent history
3. Cancer Cells in Bloodstream Show Great Diversity: Study
4. Irregular Heartbeat Poses Greater Stroke Risk for Women Than Men
5. Great recession reflux amounts to more hunger among seniors
6. Hepatitis C Causing Liver Damage in Greater Numbers: Study
7. Immigrant women giving birth in Spain suffer great stress, a study warns
8. New England Journal of Medicine hails new skin cancer drug as greatest advance yet
9. Former Vikings and NFL Greats Tackle Sleep Apnea at Upcoming Minneapolis Event
10. DotComSecrets Invites Professionals to Learn Great Tips On How to Make a Handsome Income By Working As Local Internet Marketing Consultants
11. Unemployed Americans face greater risk of mortality: UBC study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... ... February 17, 2017 , ... Focused ... innovation in the industry, according to the recent NEJM Catalyst Insights Report on ... of the NEJM Catalyst Insights Council, a qualified group of U.S. executives, clinical ...
(Date:2/18/2017)... ... 2017 , ... A new directory from the Senior Veterans ... connect elderly veterans of America's armed forces to a range of senior care ... on this year's increase in the Veterans Pension with Aid & Attendance for ...
(Date:2/17/2017)... ... 2017 , ... For the first time, International Scholarship and ... floor for the 2017 HIMSS Conference & Exhibition at the Orange ... than 40,000 healthcare industry professionals are expected at the conference, where they will ...
(Date:2/17/2017)... ... February 17, 2017 , ... Access today ... Exhibition in Orlando, Fla., February 19-23. Visitors to the company’s booth (#1778) will ... used electronic patient signatures solution in healthcare . , Since it first ...
(Date:2/17/2017)... ... February 17, 2017 , ... Cancer diagnostics workflow solution provider ... 20 – 22 in San Francisco. As part of the Tri-Conference expo, which ... workflow solution, as well as its new precision medicine platform, “Crosswalk Insight: Oncology™.” ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... 2017  AcelRx Pharmaceuticals, Inc. (Nasdaq: ... the development and commercialization of innovative therapies for ... Vincent J. Angotti has been appointed ... company,s board of directors, effective Monday, March 6, ... experience leading executive and commercial teams at public ...
(Date:2/16/2017)... , Feb. 16, 2017  Prescription pain medications ... department visit are necessary for long-term opioid use to ... Feb. 16 th edition of The New ... "Emergency physicians see more patients in acute pain than ... Parker , MD, FACEP, president of the American College ...
(Date:2/16/2017)... Research and Markets has announced the addition of the ... Function, Application, Cancer Type, Technology - Forecast to 2025" report ... ... grow at a CAGR of around 28.6% over the next decade ... Some of the prominent trends that the market is witnessing include ...
Breaking Medicine Technology: