Navigation Links
Taking the fate of stem cells in hand: RUB researchers generate immature nerve cells
Date:6/28/2012

RUB biologists have deliberately transformed stem cells from the spinal cord of mice into immature nerve cells. This was achieved by changing the cellular environment, known as the extracellular matrix, using the substance sodium chlorate. Via sugar side chains, the extracellular matrix determines which cell type a stem cell can generate. "Influencing precursor cells pharmacologically so that they transform into a particular type of cell can help in cell replacement therapies in future" says Prof. Dr. Stefan Wiese, head of the Molecular Cell Biology work group. "Therapies, for example, for Parkinson's, multiple sclerosis or amyotrophic lateral sclerosis could then become more efficient." The team describes its findings in Neural Development.

Sulphate determines the fate of stem cells

Sodium chlorate acts on metabolism enzymes in the cell which attach sulphate groups to proteins. If these sulphates are not installed, the cell continues to form proteins for the extracellular matrix, but with modified sugar side chains. These chains in turn send out signals that define the fate of the stem cells. Stem cells can not only develop into nerve cells, but also form astrocytes or oligodendrocytes, which are, for instance, responsible for the mineral balance of the nerve cells or which form their insulation layer. What happens to the stem cells if the sulphate pattern is changed by sodium chlorate was examined by Dr. Michael Karus and his colleagues.

Positive side effects: nerve cells remain immature

The RUB-laboratories of Prof. Dr. Stefan Wiese, Prof. Dr. Andreas Faissner and Prof. Dr. Irmgard Dietzel-Meyer collaborated for the study. Using antibodies, the researchers showed that cells which they had treated with sodium chlorate developed into nerve cells. They also analysed the flow of sodium ions into the cells. The result: treated cells showed a lower sodium current than mature nerve cells. Sodium chlorate thus favours the development of stem cells into nerve cells, but, at the same time, also inhibits the maturation - a positive side effect, as Wiese explains: "If sodium chlorate stops the nerve cells in an early developmental phase, this could enable them to integrate into the nervous system following a transplant better than mature nerve cells would do."


'/>"/>

Contact: Dr. Stefan Wiese
stefan.wiese@rub.de
49-234-322-2041
Ruhr-University Bochum
Source:Eurekalert

Related medicine news :

1. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
2. Seniors Stop Taking Heart Drugs In Medicare Donut Hole
3. Taking Away Car Keys Can Be Tough for Older Drivers
4. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
5. Patients taking certolizumab pegol are twice as likely to achievE ACR20 compared to placebo
6. Young Men Taking HIV Meds May Be at Risk for Bone Loss
7. New drug prevents spread of human prostate cancer cells
8. Tiny hitchhikers attack cancer cells
9. To prevent leukemias dreaded return, go for the stem cells
10. Scientists identify major source of cells defense against oxidative stress
11. Therapy exploits addiction of leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Sideline Products participated in the World Horse Expo ... Tom Seay and his production crew. Tom Seay’s program “Best of America by ... Saddle Sidekicks will be featured on April 6, 2017. After the broadcast, the ...
(Date:2/22/2017)... ... February 22, 2017 , ... ANGLESTRONG , the new ... now available on the App Store and Google Play . Florida-based ... the addiction and recovery industry, partnered with Angle to build ANGLESTRONG. The new recovery ...
(Date:2/22/2017)... ... , ... A product of digesting a micronutrient found in soy may hold ... soy foods, while others do not, a University of Pittsburgh Graduate School of Public ... made by some types of “good” gut bacteria when they metabolize isoflavones (micronutrients found ...
(Date:2/22/2017)... ... , ... Super-Sod will attend the Athens Home Show with a brand new ... from Super-Sod’s simple Athens Home Show booth of 2016, this year’s exhibit space includes ... Chris Roquemore constructed furniture from recycled pallet wood at the Super-Sod farm in Fort ...
(Date:2/22/2017)... ... ... BrightStar Care Charleston , a home care and medical staffing agency, will ... on Aging’s Senior Expo on Thursday, March 23, 2017, at the Omar Convention ... our community. We are thrilled to participate in this event because we believe it ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , February 22, 2017 ... the Dow Jones Industrial Average, and the S&P ... out of nine sectors ended Tuesday,s trading session ... sentiment, Stock-Callers.com assessed the following Medical Instruments & ... (NASDAQ: TNDM), C. R. Bard Inc. (NYSE: BCR), ...
(Date:2/22/2017)... Calif. , Feb. 22, 2017  Bioness, Inc., ... therapies, today announced the first series of successful StimRouter ... at Radboud University Medical Center (Nijmegen, Netherlands ... ( Cork, Ireland ), and Kliniek Park ... the successful launch continuing, Bioness plans to further support ...
(Date:2/22/2017)... PUNE, India , February 22, 2017 According ... (Spectroscopy, Chromatography), Measurement (On-Line, In-Line, At-Line), Products and Services (Analyzers, Probes & ... to 2021", published by MarketsandMarkets, the global market is poised to reach ... a CAGR of 13.3% from 2016 to 2021. ... ...
Breaking Medicine Technology: