Navigation Links
Taking out a cancer's co-dependency
Date:7/13/2011

A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell's revved-up metabolism and skyrocketing levels of cellular stress. Just as a cancer cell depends on a hyperactive metabolism to fuel its rapid growth, it also depends on anti-oxidative enzymes to quench potentially toxic reactive oxygen species (ROS) generated by such high metabolic demand.

Scientists at the Broad Institute and Massachusetts General Hospital (MGH) have discovered a novel compound that blocks this response to oxidative stress selectively in cancer cells but spares normal cells, with an effectiveness that surpassed a chemotherapy drug currently used to treat breast cancer. Their findings, based on experiments in cell culture and in mice, appear online in Nature on July 13.

The plant-based compound piperlongumine (PL), derived from the fruit of a pepper plant found in southern India and southeast Asia, appears to kill cancer cells by jamming the machinery that dissipates high oxidative stress and the resulting ROS. Normal cells have low levels of ROS, in tune with their more modest metabolism, so they don't need high levels of the anti-oxidant enzymes that PL stymies once they pass a certain threshold.

"Piperlongumine targets something that's not thought to be essential in normal cells," said Stuart L. Schreiber, a senior co-author and director of the Broad's Chemical Biology Program. "Cancer cells have a greater dependence on ROS biology than normal cells."

Sam W. Lee and Anna Mandinova, senior co-authors from the Cutaneous Biology Research Center (CBRC) at MGH, weren't looking for a ROS inhibitor when they found PL. Their interest lay in the tumor suppressor gene p53, which is mutated in more than half of all cancer types. Teaming up with the Broad's Chemical Biology Program and Platform to screen libraries of chemical compo
'/>"/>

Contact: Nicole Davis
ndavis@broadinstitute.org
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Taking Chemo Drug Continuously Delayed Lung Cancers Return
2. Kids Taking ADHD Drugs at Low Risk for Heart Problems: Study
3. No increase in severe cardiovascular events for children, adolescents taking ADHD medications
4. Taking additional selenium will not reduce cancer risk
5. Women Taking Calcium Supplements May Risk Heart Health, Researchers Say
6. Taking Responsibility for Own Health Often Not Enough
7. Leukemia Patients Taking Gleevec Achieve Normal Death Rate
8. Taking tamoxifen to prevent breast cancer can save lives and money
9. Follow-Up Deemed Lacking for People Taking Opioids
10. Taking Short Breaks From Sitting May Help Waistline and Heart
11. PSA test better predicts cancer in men taking prostate-shrinking drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... 31, 2015 , ... Three Bakers Gluten Free Bakery launched the redesign of ... and easy-to-find information on their offering of gluten-free breads and pizzas, living without gluten, ... way for us to share information about our gluten free product offerings, but also ...
(Date:8/31/2015)... ... August 31, 2015 , ... Finnleo is pleased ... Terrace Outdoor Sauna. After months of extensive engineering and design of our newest sauna ... withstand the elements and is offered at a very attractive price-point. , Before ...
(Date:8/31/2015)... ... August 31, 2015 , ... DR. LUCIANA ON ... (aka Dr. Luciana) received a total of three Silver Medal awards at ... Best (Dis)ability Film. Dr. Luciana co-wrote and co-produced this pilot with Del Weston, ...
(Date:8/31/2015)... ... 31, 2015 , ... American Family Care (AFC), the nation’s ... presence in Tennessee with the opening of a new urgent care facility at ... sixteenth in Tennessee, and 148th in the U.S. overall. , “We’re excited to ...
(Date:8/31/2015)... ... , ... The more hours young adults spend watching television each day, the ... circumference, a 15-year analysis by the University of Pittsburgh Graduate School of Public Health ... young adulthood is an important time to intervene and promote less television viewing, according ...
Breaking Medicine News(10 mins):Health News:Three Bakers Gluten Free Bakery Announces Launch of New Website 2Health News:Say “Hello” to the Brand New Finnleo Terrace Outdoor Saunas 2Health News:Actor/Writer/Director/Psychology Professor Luciana Lagana Receives Three Wins at the 2015 Global Independent Film Awards for the TV Pilot Dr. Luciana on Aging and Falling 2Health News:State-of-the-Art Urgent Care Facility Opening in Knoxville 2Health News:Watching More TV as a Young Adult Predicts Obesity 2Health News:Watching More TV as a Young Adult Predicts Obesity 3
... by a New York University dental research team has ... are more likely to develop gestational diabetes mellitus than ... study, led by Dr. Ananda P. Dasanayake, a professor ... of Dentistry, followed 256 women at New Yorks Bellevue ...
... neurons that were genetic match improved symptoms, avoided ... Therapeutic cloning successfully treated Parkinson,s disease in mice, ... dopamine-producing neurons with an identical genetic profile to ... improve the neurological performance of the diseased animals, ...
... FARMINGTON HILLS, Mich., March 24 During National Root,Canal ... part series of articles,is available for publication courtesy of ... for aging, facts about,root canals and new technology that ... heart?, Dental health can affect your overall health, ...
... March 24 Sharps Compliance Corp.,(OTC Bulletin Board: ... disposal solutions for small quantity generators of,medical waste, ... the,position of Senior Vice President of Operations. Mr. ... ("GMD"), a developer and,manufacturer of medical devices, where ...
... where teens go when not in or near home or ... health-related behavior such as smoking or sexual activity" The answer ... , In a paper published in the April issue ... School of Medicine report on a pilot study which evaluated ...
... Accepts as Complete DNV,s ... Hospital Deeming Authority, HOUSTON, March 24 The U.S. ... that its application to,deem hospitals in compliance with the Medicare ... formal review., If approved, DNV stands to become the ...
Cached Medicine News:Health News:NYU dental researchers find evidence of periodontal disease leading to gestational diabetes 2Health News:Therapeutic Cloning Works in Mice With Parkinson's 2Health News:Therapeutic Cloning Works in Mice With Parkinson's 3Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 2Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 3Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 4Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 5Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 6Health News:Sharps Compliance Corp. Announces Appointment of Al Aladwani as its Senior Vice President of Operations 2Health News:Sharps Compliance Corp. Announces Appointment of Al Aladwani as its Senior Vice President of Operations 3Health News:Risky teen behavior may not occur at home or school: but how to track? 2Health News:DNV Healthcare Advances in Bid to Accredit Hospitals 2
(Date:8/31/2015)... TWINSBURG, Ohio , Aug. 31, 2015 /PRNewswire/ ... and applications, has acquired MACTek Corporation, a leading ... part of Pepperl+Fuchs, strategy to further extend its ... the WirelessHART market.    "We are ... to our existing portfolio," said Jim Bolin ...
(Date:8/31/2015)... 2015 Thousands of people will peacefully demonstrate ... opioid addiction epidemic at dozens of rallies across the ... the United States has experienced ... opioids and heroin, yet the President has never once ... letter to President Obama , rally organizers compared ...
(Date:8/31/2015)... , August 31, 2015 ... the global cardiovascular monitoring and diagnostic devices market ... predicted to reach a value of approximately US$7.0 ... 9.7% between 2013 and 2019. The title of ... Market (ECG, Holter Monitors, Event Monitors, Cardiovascular Diagnostic ...
Breaking Medicine Technology:Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 2Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 3Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 4Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 5
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
The HT-PB is a implantable bipolar tined permanent pacing lead for stimulation of the ventricle....
... Flextend lead is a ... with an extendable/retractable active-fixation ... design offers various lead ... implantation in the atrium ...
The RU is a low profile implantable bipolar tined permanent pacing lead for stimulation of either the atrium (J model) or the ventricle (straight model)....
Medicine Products: