Navigation Links
Taking aim at metastatic lung tumors

A new study uses a sophisticated genomic analysis to unravel some of the complex cellular signals that drive the deadly invasive spread of lung cancer. The research, published by Cell Press in the June issue of the journal Cancer Cell, identifies specific molecules involved in the often fatal metastasis of a common type of non-small cell lung cancer (NSCLC) and uses this information to design effective therapeutic strategies.

"Previous cancer genomics studies have established a number of oncogene and tumor suppressor pathways as important for the initiation and maintenance of NSCLC," explains senior study author, Dr. Kwok-Kin Wong from the Dana-Farber Cancer Institute in Boston. "However, the molecular alterations necessary for invasion and metastases of NSCLC are less well-defined. Because metastasis causes much of the morbidity and incurability of cancer, there is an urgent need to elucidate the events underlying this biological process.

Dr. Wong and colleagues had recently shown that the loss of the Lkb1 tumor suppressor gene in a significant population of lung tumors results in metastasis in mice. Although the Lkb1 gene has also been linked with about 30% of human lung cancers, the pathways responsible for the metastatic effects had not been identified. To gain insight into the signaling pathways that underlie Lkb1-deficient lung tumors, the research team performed a comprehensive analysis of the genomic and signaling protein signatures of primary and metastatic lung tumors.

Loss of Lkb1 in mouse and human lung cancer cells was associated with an increase in the activity of proteins that are known to modulate cell motility and adhesion. Importantly, combined pharmacological inhibition of these key regulatory proteins in Lkb1-deficient cells decreased cell migration and induced tumor regression.

"Our analyses of primary and metastatic Lkb1-deficient mouse lung tumors have shown that progression to metastatic lung cancer is associated with unique gene and protein signatures," concludes Dr. Wong. "Importantly, our findings indicate that despite the complex transcriptional and signaling changes that occur in the setting of Lkb1 loss and progression of NSCLC, these tumors may still be addicted to isolated oncogenic events that can be successfully therapeutically targeted."


Contact: Cathleen Genova
Cell Press

Related medicine news :

1. Genetic differences may influence joint pain among women taking lifesaving breast cancer drugs
2. Robin Leedy & Associates Hires Digital Content Producer, Taking Social Media for Drugstore Brands Digital Capability to the Next Level
3. Taking the final step from the bench to the hospital or clinic bedside
4. A Womans Touch Encourages Financial Risk-Taking
5. Harmony Information Systems to Host Free Webcast: Learn How Vermont and Pennsylvania Are Taking Control of Medicaid Waivers Management
6. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
7. Triple Heart Valve Replacement Saves Local Women's Life at Portneuf Medical Center: Woman Gets a Second Chance at Life After Taking Fen-Phen
8. Taking Care of Your 'Girls': A Fun and Open Forum for Young Women Hosted by Abington Memorial Hospital
9. Binge drinking doesnt affect next-day student test-taking
10. People with prediabetes not taking adequate precautions to avoid diabetes
11. Celebrate National Childrens Dental Health Month by Taking Care of Tiny Teeth
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... Sept. 25, 2017   Montrium , an ... solutions, today—from the IQPC Trial Master Files & ... NL)—announced that EastHORN Clinical Services has selected ... and TMF management. EastHORN, a leading European contract ... to increase transparency to enable greater collaboration with ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: