Navigation Links
Taking aim at metastatic lung tumors
Date:6/14/2010

A new study uses a sophisticated genomic analysis to unravel some of the complex cellular signals that drive the deadly invasive spread of lung cancer. The research, published by Cell Press in the June issue of the journal Cancer Cell, identifies specific molecules involved in the often fatal metastasis of a common type of non-small cell lung cancer (NSCLC) and uses this information to design effective therapeutic strategies.

"Previous cancer genomics studies have established a number of oncogene and tumor suppressor pathways as important for the initiation and maintenance of NSCLC," explains senior study author, Dr. Kwok-Kin Wong from the Dana-Farber Cancer Institute in Boston. "However, the molecular alterations necessary for invasion and metastases of NSCLC are less well-defined. Because metastasis causes much of the morbidity and incurability of cancer, there is an urgent need to elucidate the events underlying this biological process.

Dr. Wong and colleagues had recently shown that the loss of the Lkb1 tumor suppressor gene in a significant population of lung tumors results in metastasis in mice. Although the Lkb1 gene has also been linked with about 30% of human lung cancers, the pathways responsible for the metastatic effects had not been identified. To gain insight into the signaling pathways that underlie Lkb1-deficient lung tumors, the research team performed a comprehensive analysis of the genomic and signaling protein signatures of primary and metastatic lung tumors.

Loss of Lkb1 in mouse and human lung cancer cells was associated with an increase in the activity of proteins that are known to modulate cell motility and adhesion. Importantly, combined pharmacological inhibition of these key regulatory proteins in Lkb1-deficient cells decreased cell migration and induced tumor regression.

"Our analyses of primary and metastatic Lkb1-deficient mouse lung tumors have shown that progression to metastatic lung cancer is associated with unique gene and protein signatures," concludes Dr. Wong. "Importantly, our findings indicate that despite the complex transcriptional and signaling changes that occur in the setting of Lkb1 loss and progression of NSCLC, these tumors may still be addicted to isolated oncogenic events that can be successfully therapeutically targeted."


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Genetic differences may influence joint pain among women taking lifesaving breast cancer drugs
2. Robin Leedy & Associates Hires Digital Content Producer, Taking Social Media for Drugstore Brands Digital Capability to the Next Level
3. Taking the final step from the bench to the hospital or clinic bedside
4. A Womans Touch Encourages Financial Risk-Taking
5. Harmony Information Systems to Host Free Webcast: Learn How Vermont and Pennsylvania Are Taking Control of Medicaid Waivers Management
6. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
7. Triple Heart Valve Replacement Saves Local Women's Life at Portneuf Medical Center: Woman Gets a Second Chance at Life After Taking Fen-Phen
8. Taking Care of Your 'Girls': A Fun and Open Forum for Young Women Hosted by Abington Memorial Hospital
9. Binge drinking doesnt affect next-day student test-taking
10. People with prediabetes not taking adequate precautions to avoid diabetes
11. Celebrate National Childrens Dental Health Month by Taking Care of Tiny Teeth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... To meet a growing ... healthcare industry, The University of Scranton is adding a Certificate in Health Informatics ... career in rapidly growing field of healthcare information. , Healthcare organizations are ...
(Date:5/30/2016)... ... May 30, 2016 , ... Zane Benefits, the leader in ... original infographic, " Health Benefits Reimbursement Compliance Timeline ." , The new ... with various federal regulations and reforms. , Navigating the new health reforms can ...
(Date:5/29/2016)... Viejo, CA (PRWEB) , ... May 29, 2016 , ... ... Volume 3 let's the user control the style of their project," said Christina Austin ... set of 30 self-animating web-themed intros created exclusively for use in Final Cut Pro ...
(Date:5/28/2016)... ... ... where’s it’s easy to spot the neon lights of chains serving fast food, one of ... taste for real food. , On May 13, the Best Western Plus Kelowna ... focusing on dishes made by hand with wholesome, organic ingredients that are sourced locally whenever ...
(Date:5/27/2016)... ... ... An influential resource amongst nurses and professionals in the health care world, ... of topics detailing why we appreciate nurses in so many different ways. From exclusive ... being in a major recession to one of the hottest growing professions in any ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... , May 26, 2016 ... With Both Cost Savings and Overall Decreased ... (LSE: BTG), an international specialist healthcare company, has ... the 21st Annual Meeting of ISPOR (International Society ... of hepatocellular carcinoma (HCC) using yttrium-90 glass microspheres ...
(Date:5/26/2016)... May 26, 2016 Since its ... into an essential life science tool for conducting genetic ... BCC Research reveals in its new report that the ... phase, one powered by a range of new applications ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
(Date:5/25/2016)... , May 25, 2016 According ... by Type (3D, 2D, 4D), by Therapeutic Area (Oncology, ... End User (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast ... global Medical Animation Market for the forecast period of ... USD 301.3 Million by 2021 from USD 117.3 Million ...
Breaking Medicine Technology: