Navigation Links
Taking Aim at Relapse of Leukemia in Kids
Date:6/17/2009

Researchers say discovery could lead to lifesaving drugs ,,,,

WEDNESDAY, June 17 (HealthDay News) -- Scientists have identified molecules that enable tumor cells to invade the nervous system of patients with a blood-borne childhood cancer, a finding that may lead to the development of drugs that block these molecules and prevent relapse.

In T-cell acute lymphoblastic leukemia (T-ALL), which primarily strikes children and adolescents, the bone marrow makes too many white blood cells.

"In general, [T-ALL] is treatable with basic chemotherapy and radiation, so close to 80 percent of kids can be cured," study leader Ioannis Aifantis, an associate professor of pathology and co-director of the Cancer Stem Cell Program at the New York University Cancer Institute, said in a university news release. "But you have a very high rate of relapse. And after the relapse, it is not treatable because the cancer occurs in tricky places, like the central nervous system."

In research with mice, Aifantis and colleagues found that a protein receptor (CCR7) embedded on the outer surface of leukemic cells enables the cancer cells to infiltrate the brain and spinal cord.

"What we have found is that leukemic cells over-express this receptor," Aifantis said. "If you knock out this receptor, these cells will not go to the brain under any circumstances."

The researchers also found that a protein called CCL21 acts as a "come-hither" signal for CCR7 protein receptors. CCL21 was found in tiny veins of the brain near infiltrating tumor cells.

"Perhaps there are antibodies or small molecules that can block the interaction between these two proteins to reduce their interactions and, hopefully, that could be used as a type of prophylactic treatment to prevent a relapse in the central nervous system among patients who have already been treated for leukemia," Aifantis said.

The study is in the June 18 issue of t
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Value of Taking Aspirin to Cut Heart Risk Varies
2. Financial Distress Taking Toll on Employee Health
3. Taking a Bite Out of Rabies: Merial Provides Rabies Awareness and Prevention Training to Noahs Wish Pet Disaster Relief Organization
4. Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
5. Taking folic acid for a year before pregnancy may reduce risk of preterm birth
6. APA Poll Finds Economic Stress Taking a Toll on Men
7. Polls Show Americans Concerned About Swine Flu, Taking Actions to Protect Themselves
8. Taking Control of Your Diabetes Conference Returns to Indianapolis to Bring Answers, Advocacy and Hope for People With Diabetes
9. Seniors Should Watch for Drug Interactions When Taking Multiple Medications
10. Hollywood Presbyterian Medical Center: Taking the Message of Trust to the Streets of LA
11. Economic Downturn Taking Toll on Patients and Communities Hospitals Serve: New Survey Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Taking Aim at Relapse of Leukemia in Kids
(Date:10/30/2014)... Global prebiotics market is expected to ... new study by Grand View Research, Inc. Positive outlook ... and fat free products owing to increased concerns over ... over the forecast period. , View full report with ... beverage was the largest application segment with market volume ...
(Date:10/30/2014)... South Carolina (PRWEB) October 30, 2014 ... and should be more vigorously exercised to help maintain ... recently authored the book ‘Dementia Express: Lose Your Memory ... book uses counterintuitive reasoning and sometimes conflicting attitudes to ... course for the mind, a reader must decipher the ...
(Date:10/30/2014)... Sound Telecom, a leader in the call center industry, just ... they wonder, “Should I use an answering service?” The graphic ... a series of yes or no questions that ultimately ends ... many considerations and scenarios that come into play when deciding ... This decision infographic serves as a bit of a map ...
(Date:10/30/2014)... Amy Norton HealthDay ... Exposure to a common plastics, chemical during pregnancy may have ... hints. Researchers found that baby boys born to moms ... have a shorter anogenital distance -- the space between the ... and it,s considered a marker of exposure to androgens ("male" ...
(Date:10/30/2014)... -- Eating a low-carb, high-fat diet could help control ... research. A review of five studies found ... on foods like bacon, eggs, heavy cream, butter, fish ... whose condition doesn,t improve with medication. "We need ... epilepsy whose seizures are not stopped by medications," study ...
Breaking Medicine News(10 mins):Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 2Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 4Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 5Health News:‘Dementia Express’ Offers Contradictory and Sometimes Reverse Thinking, All to Keep its Reader on Their Toes With an Active Mind. 2Health News:Sound Telecom Produces Decision Infographic to Aid Businesses 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 3Health News:High-Fat, Low-Carb Diet May Help With Tough-to-Treat Epilepsy 2Health News:High-Fat, Low-Carb Diet May Help With Tough-to-Treat Epilepsy 3
... NHS Hospital Trusts on Sunday, thankfully no patient data ... in charge of the IT services in NHS conveyed ... were interrupted due to the failure of equipment that ... will be maintained till ,the system is restored. ...
... problems may face the risk of several underlying medical complications, ... ,A team from the New England Research Institute in Massachusetts ... over 15 years and looked at markers for metabolic syndrome, ... edition of Daily Mail. ,These markers include raised ...
... (HPV) vaccine which is said to prevent about 75 percent ... and even women already exposed to the disease causing virus//, ... papillomavirus (HPV) has been approved for women aged 9 to ... and gynecology at the University of California-Irvine, argued that with ...
... 9,000 Danish residents revealed that a specific mutation in the ... breast cancer in her lifetime. The study, which was the ... the cancer risk associated with it, in the general population, ... Journal of Clinical Oncology. ,"Our study shows ...
... stop overdoses in heroin addicts. Hence many needle exchange ... news follows the deaths of at least 400 people ... ,Prevention Point Philadelphia, a nonprofit organization responsible for needle ... of naloxone prescriptions through a physician. "If people have ...
... the University of Florida, Gainesville, mice based experiments were found ... of the heart.// , This new technique was ... that damages the heart. The findings, published July 27 in ... studies in humans that could begin as soon as early ...
Cached Medicine News:Health News:Demand for More Widespread Use of HPV Vaccine 2Health News:Demand for More Widespread Use of HPV Vaccine 3Health News:CHEK 2 Gene Mutation Triples Breast Cancer Risk 2Health News:Gene Therapy Technique for Inherited Heart Problems in The Pipeline 2Health News:Gene Therapy Technique for Inherited Heart Problems in The Pipeline 3Health News:Gene Therapy Technique for Inherited Heart Problems in The Pipeline 4
(Date:10/30/2014)... , Oct. 30, 2014   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade ... and precision thermal shipping products for cells ... quarter 2014 financial results will be released on Thursday, ... a conference call and live webcast at 1:30 p.m. ...
(Date:10/30/2014)... 30, 2014 Extensiv ... Aufbau von Kuhmilchverträglichkeit     Kuhmilchproteinallergie (KMPA) ... Säuglingen und Kleinkindern. Der bisher übliche Umgang ... der Babys bzw. deren stillenden Mütter Milchproteine ... sich bei einer beträchtlichen Anzahl von Kindern ...
(Date:10/30/2014)... , Oct. 30, 2014 Today, DripDrop, ... announced that it was awarded a two-year contract, ... services company that serves the more than 100,000 ... Hospital Association and Provista.  DripDrop ... feedback from member hospitals who attended the recent ...
Breaking Medicine Technology:BioLife Solutions to Report Financial Results for Third Quarter 2014 and Provide Business Update on November 6, 2014 2Experten präsentieren neuste Forschungsergebnisse auf dem Allergy Day 2Experten präsentieren neuste Forschungsergebnisse auf dem Allergy Day 3DripDrop Partners With Novation To Help Hospitals Address I.V. Saline Solution Shortages; ORS Product Used For Ebola Outbreak 2DripDrop Partners With Novation To Help Hospitals Address I.V. Saline Solution Shortages; ORS Product Used For Ebola Outbreak 3DripDrop Partners With Novation To Help Hospitals Address I.V. Saline Solution Shortages; ORS Product Used For Ebola Outbreak 4
... MEETING, Pa., Feb. 16, 2012 ECRI Institute ... approaches to improving patient care, has released CT ... to give hospital leaders an at-a-glance overview of the ... popular makes and models, to average pricing, and most ...
... a leading pharmaceutical CRO, announced today that Robert Gwozdz, ... efforts.  According to Mark Mitchnick, the company,s CEO, "PSI ... across many dosage forms and drug types.  For instance, ... molecules of which about 80% fall into BCS II.  ...
Cached Medicine Technology:ECRI Institute Guides Hospital Decision-Makers in the Purchase of CT Scanning Systems 2ECRI Institute Guides Hospital Decision-Makers in the Purchase of CT Scanning Systems 3Particle Sciences Hires Robert Gwozdz to Head Oral Formulation 2
IMMCO ANA Elisa meets the guidelines for the laboratory diagnosis and monitoring of systemic autoimmune rheumatic diseases intended for the use of clinical pathologists and laboratory physicians....
An enzyme-linked immuno-sorbent assay for the detectionand quantitation of anti-tissue Transglutaminase in serum of patients with Celiac Disease and Dermatitis Herpetiformis....
Jerome Halo Traction Units provide optimum immobilization for unstable injuries of the spine. The Generation 80 superstructure is available with either 2-point (serrated disk), or 3-point (flexion/ex...
... Boston Scoliosis Brace™ for neuromuscular ... a lightweight, soft, and easy ... maximum comfort. The Soft ... of non-cracking orthopedic grade copolymer ...
Medicine Products: