Navigation Links
Taking Aim at Relapse of Leukemia in Kids
Date:6/17/2009

Researchers say discovery could lead to lifesaving drugs ,,,,

WEDNESDAY, June 17 (HealthDay News) -- Scientists have identified molecules that enable tumor cells to invade the nervous system of patients with a blood-borne childhood cancer, a finding that may lead to the development of drugs that block these molecules and prevent relapse.

In T-cell acute lymphoblastic leukemia (T-ALL), which primarily strikes children and adolescents, the bone marrow makes too many white blood cells.

"In general, [T-ALL] is treatable with basic chemotherapy and radiation, so close to 80 percent of kids can be cured," study leader Ioannis Aifantis, an associate professor of pathology and co-director of the Cancer Stem Cell Program at the New York University Cancer Institute, said in a university news release. "But you have a very high rate of relapse. And after the relapse, it is not treatable because the cancer occurs in tricky places, like the central nervous system."

In research with mice, Aifantis and colleagues found that a protein receptor (CCR7) embedded on the outer surface of leukemic cells enables the cancer cells to infiltrate the brain and spinal cord.

"What we have found is that leukemic cells over-express this receptor," Aifantis said. "If you knock out this receptor, these cells will not go to the brain under any circumstances."

The researchers also found that a protein called CCL21 acts as a "come-hither" signal for CCR7 protein receptors. CCL21 was found in tiny veins of the brain near infiltrating tumor cells.

"Perhaps there are antibodies or small molecules that can block the interaction between these two proteins to reduce their interactions and, hopefully, that could be used as a type of prophylactic treatment to prevent a relapse in the central nervous system among patients who have already been treated for leukemia," Aifantis said.

The study is in the June 18 issue of the journal Nature.

More information

The American Cancer Society has more about childhood leukemia.



-- Robert Preidt



SOURCE: NYU Langone Medical Center, news release, June 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Value of Taking Aspirin to Cut Heart Risk Varies
2. Financial Distress Taking Toll on Employee Health
3. Taking a Bite Out of Rabies: Merial Provides Rabies Awareness and Prevention Training to Noahs Wish Pet Disaster Relief Organization
4. Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
5. Taking folic acid for a year before pregnancy may reduce risk of preterm birth
6. APA Poll Finds Economic Stress Taking a Toll on Men
7. Polls Show Americans Concerned About Swine Flu, Taking Actions to Protect Themselves
8. Taking Control of Your Diabetes Conference Returns to Indianapolis to Bring Answers, Advocacy and Hope for People With Diabetes
9. Seniors Should Watch for Drug Interactions When Taking Multiple Medications
10. Hollywood Presbyterian Medical Center: Taking the Message of Trust to the Streets of LA
11. Economic Downturn Taking Toll on Patients and Communities Hospitals Serve: New Survey Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Taking Aim at Relapse of Leukemia in Kids
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: