Navigation Links
Taking Aim at Relapse of Leukemia in Kids

Researchers say discovery could lead to lifesaving drugs ,,,,

WEDNESDAY, June 17 (HealthDay News) -- Scientists have identified molecules that enable tumor cells to invade the nervous system of patients with a blood-borne childhood cancer, a finding that may lead to the development of drugs that block these molecules and prevent relapse.

In T-cell acute lymphoblastic leukemia (T-ALL), which primarily strikes children and adolescents, the bone marrow makes too many white blood cells.

"In general, [T-ALL] is treatable with basic chemotherapy and radiation, so close to 80 percent of kids can be cured," study leader Ioannis Aifantis, an associate professor of pathology and co-director of the Cancer Stem Cell Program at the New York University Cancer Institute, said in a university news release. "But you have a very high rate of relapse. And after the relapse, it is not treatable because the cancer occurs in tricky places, like the central nervous system."

In research with mice, Aifantis and colleagues found that a protein receptor (CCR7) embedded on the outer surface of leukemic cells enables the cancer cells to infiltrate the brain and spinal cord.

"What we have found is that leukemic cells over-express this receptor," Aifantis said. "If you knock out this receptor, these cells will not go to the brain under any circumstances."

The researchers also found that a protein called CCL21 acts as a "come-hither" signal for CCR7 protein receptors. CCL21 was found in tiny veins of the brain near infiltrating tumor cells.

"Perhaps there are antibodies or small molecules that can block the interaction between these two proteins to reduce their interactions and, hopefully, that could be used as a type of prophylactic treatment to prevent a relapse in the central nervous system among patients who have already been treated for leukemia," Aifantis said.

The study is in the June 18 issue of the journal Nature.

More information

The American Cancer Society has more about childhood leukemia.

-- Robert Preidt

SOURCE: NYU Langone Medical Center, news release, June 17, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Value of Taking Aspirin to Cut Heart Risk Varies
2. Financial Distress Taking Toll on Employee Health
3. Taking a Bite Out of Rabies: Merial Provides Rabies Awareness and Prevention Training to Noahs Wish Pet Disaster Relief Organization
4. Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
5. Taking folic acid for a year before pregnancy may reduce risk of preterm birth
6. APA Poll Finds Economic Stress Taking a Toll on Men
7. Polls Show Americans Concerned About Swine Flu, Taking Actions to Protect Themselves
8. Taking Control of Your Diabetes Conference Returns to Indianapolis to Bring Answers, Advocacy and Hope for People With Diabetes
9. Seniors Should Watch for Drug Interactions When Taking Multiple Medications
10. Hollywood Presbyterian Medical Center: Taking the Message of Trust to the Streets of LA
11. Economic Downturn Taking Toll on Patients and Communities Hospitals Serve: New Survey Finds
Post Your Comments:
Related Image:
Taking Aim at Relapse of Leukemia in Kids
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: