Navigation Links
Taking Aim at Relapse of Leukemia in Kids
Date:6/17/2009

Researchers say discovery could lead to lifesaving drugs ,,,,

WEDNESDAY, June 17 (HealthDay News) -- Scientists have identified molecules that enable tumor cells to invade the nervous system of patients with a blood-borne childhood cancer, a finding that may lead to the development of drugs that block these molecules and prevent relapse.

In T-cell acute lymphoblastic leukemia (T-ALL), which primarily strikes children and adolescents, the bone marrow makes too many white blood cells.

"In general, [T-ALL] is treatable with basic chemotherapy and radiation, so close to 80 percent of kids can be cured," study leader Ioannis Aifantis, an associate professor of pathology and co-director of the Cancer Stem Cell Program at the New York University Cancer Institute, said in a university news release. "But you have a very high rate of relapse. And after the relapse, it is not treatable because the cancer occurs in tricky places, like the central nervous system."

In research with mice, Aifantis and colleagues found that a protein receptor (CCR7) embedded on the outer surface of leukemic cells enables the cancer cells to infiltrate the brain and spinal cord.

"What we have found is that leukemic cells over-express this receptor," Aifantis said. "If you knock out this receptor, these cells will not go to the brain under any circumstances."

The researchers also found that a protein called CCL21 acts as a "come-hither" signal for CCR7 protein receptors. CCL21 was found in tiny veins of the brain near infiltrating tumor cells.

"Perhaps there are antibodies or small molecules that can block the interaction between these two proteins to reduce their interactions and, hopefully, that could be used as a type of prophylactic treatment to prevent a relapse in the central nervous system among patients who have already been treated for leukemia," Aifantis said.

The study is in the June 18 issue of the journal Nature.

More information

The American Cancer Society has more about childhood leukemia.



-- Robert Preidt



SOURCE: NYU Langone Medical Center, news release, June 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Value of Taking Aspirin to Cut Heart Risk Varies
2. Financial Distress Taking Toll on Employee Health
3. Taking a Bite Out of Rabies: Merial Provides Rabies Awareness and Prevention Training to Noahs Wish Pet Disaster Relief Organization
4. Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
5. Taking folic acid for a year before pregnancy may reduce risk of preterm birth
6. APA Poll Finds Economic Stress Taking a Toll on Men
7. Polls Show Americans Concerned About Swine Flu, Taking Actions to Protect Themselves
8. Taking Control of Your Diabetes Conference Returns to Indianapolis to Bring Answers, Advocacy and Hope for People With Diabetes
9. Seniors Should Watch for Drug Interactions When Taking Multiple Medications
10. Hollywood Presbyterian Medical Center: Taking the Message of Trust to the Streets of LA
11. Economic Downturn Taking Toll on Patients and Communities Hospitals Serve: New Survey Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Taking Aim at Relapse of Leukemia in Kids
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
Breaking Medicine Technology: