Navigation Links
Takeda statement on ACTOS meta-analysis published in the Journal of the American Medical Association
Date:9/11/2007

Deerfield, IL, September 11, 2007 Takeda Pharmaceuticals North America, Inc. is aware of the review of ACTOS (pioglitazone HCl) data conducted by A. Michael Lincoff, M.D., and colleagues at the Cleveland Clinic, published in the Journal of the American Medical Association which concluded that ACTOS is associated with a significantly lower risk of heart attack, stroke, or death among a diverse population of 16,390 patients with diabetes versus control therapy.

This new meta-analysis is consistent with the depth and breadth of ACTOS cardiovascular data: ACTOS studies, conducted over the past 10 years, including short- and long-term trials, as well as prospective and observational studies, have shown no evidence that ACTOS is associated with an increased risk of heart attack, stroke, or death.

Meta-analyses are pooled data across a number of studies. Although not definitive, they can offer insight into aspects of a compound or product that may not be readily available from individual studies. The overall effect calculated from a group of like or similar randomized trials can provide an estimate of the drugs overall effects in an expanded population.

This meta-analysis adds important information to the body of evidence regarding ACTOS and macrovascular ischemic events, and further documents the consistency of data from prospective studies, to meta-analysis, to observational studies.

Critical in this body of data is PROactive (PROspective PioglitAzone Clinical Trial In MacroVascular Events), a trial of patients with type 2 diabetes who are at high risk for cardiovascular events. Results from this prospective, randomized, placebo-controlled outcomes trial - considered by scientists to be the most scientifically rigorous type of study - were reviewed by the FDA and added to the ACTOS label. These data show no increase in mortality or total macrovascular events with ACTOS. ACTOS is the only thiazolidinedione (TZD) with safety data from a cardiovascular outcomes trial in its label.

Given the strength and consistency of the ACTOS data as demonstrated by the prospective studies, meta-analysis, and observational studies, Takeda remains confident in the ACTOS safety profile regarding the risk of macrovascular ischemic events.


'/>"/>

Contact: Amy Losak
amy.losak@ketchum.com
646-935-3917
Ketchum
Source:Eurekalert

Related medicine news :

1. Merck and Takeda to collaborate in the sale of Cancer drug Matuzumab
2. Substituting soymilk for lactose intolerant students n schools: a great option
3. ACTOS Linked to Several Cardiovascular Benefits
4. Lactose-Intolerant kids need to take dairy products to meet nutrient requirements
5. Actos Linked To Bone Fractures In Diabetic Women
6. Largest Ever Study of Genetics Behind Common Diseases Published
7. A Just Published Book Promises To Guide Women Regarding Their Frequent UTI’
8. Findings on Dangerous Parasite, Toxoplasma Gondii Published
9. Siddha Medicine Texts to Be Published in English
10. Journal Recommends How To Improve The Performance Of Health Workers
11. Medical Journals should create awareness on Child survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Today, InhaleLabs.com (Inhale) offilially launched ... medication by matching users with high quality water pipes within an ideal price range. ... , Inhale was founded by two brothers, Nick and Mike Hunter, who use medical ...
(Date:6/24/2016)... ... ... Dr. Seema Daulat, a native Texan and University of Texas at Austin magna ... 13, 2016. , Dr. Daulat earned her Doctorate of Medicine (MD) at The University ... Agape Clinic serving Dallas’ underprivileged community. , Following medical school, Dr. Daulat completed both ...
(Date:6/23/2016)... ... , ... An article published June 8 on AOL News describes ... cancer in individuals with unhealthy oral hygiene habits. The article goes on to state ... gum disease, brushed their teeth on a daily basis, wore dentures and if they ...
(Date:6/23/2016)... ... June 23, 2016 , ... The Mechille Wilson Agency, a ... Jasper County and the surrounding region, is initiating a charity drive to assist a ... funds earmarked for a scholarship fund that will be presented to the chosen student ...
(Date:6/23/2016)... McKinney, Texas (PRWEB) , ... June 23, 2016 , ... ... the special operations community. He turned towards the water to find peace and set ... funds for a veterans charity and turned to the internet. He came across the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma ... as the company,s second affiliate in Latin America . ... ... Astellas Farma Colombia ... ...
Breaking Medicine Technology: