Navigation Links
Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
Date:11/3/2008

A very difficult-to-treat child leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on. The study, led by researchers at Children's Hospital Boston and the Dana-Farber Cancer Institute, is the cover article in the November 4 issue of Cancer Cell.

While cure rates for the major types of childhood leukemia are now about 80 percent, they are much lower for patients with a subtype of acute lymphoblastic leukemia (ALL) known as MLL-AF4, which accounts for 5 percent of all ALLs but 70 percent of ALLs striking infants. Children with this form of leukemia suffer rapid relapses and have a cure rate of just under 50 percent with chemotherapy.

"MLL-AF4 leukemias are very difficult to treat and in desperate need of new therapeutic approaches," says senior investigator Scott Armstrong, MD, PhD, of Children's and Dana-Farber. Like other other leukemias, the disease leads to abnormally high numbers of immature, dysfunctional white blood cells that crowd out the bone marrow, interfering with its ability to produce healthy blood cells.

The researchers, led by Armstrong, Andrei Krivtsov, PhD and Zhaohui Feng, also of Children's and Dana-Farber, first developed a mouse model of MLL-AF4, which had eluded scientists in the past. They then showed that the abnormal "fusion" protein that characterizes the disease, also known as MLL-AF4, goes to the cell's DNA and causes abnormal modification of one of the histones, "scaffolding" proteins that give chromosomes their shape and help control gene activation. As a result of this epigenetic change, chromosome structure is altered. This jump-starts activity of a diverse group of genes, including some known to be critical in initiating leukemia.

Studying samples from children with MLL-AF4 leukemias, the team made the same observations.
'/>"/>

Contact: Rob Graham
rob.graham@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Tackling Triglycerides: 8 Ways to Solve a Big Fat Problem, From the Harvard Heart Letter
2. Lack of political will and the subordination of women are major barriers to tackling AIDS
3. Southern California Parents and Kids Take Healthy Steps in Tackling Childhood Obesity
4. Public Health Leaders Unveil Blueprint for Tackling Climate Change
5. Tackling depression in cancer patients can extend life
6. Experts to share how research is tackling cancer
7. Tackling Obesity Through Education and FUNdraising
8. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
9. Revolutionary New Technique Uses Onyx to Fill Hard-To-Treat Aneurysms
10. Relaxation training may improve control of hard-to-treat systolic hypertension
11. Blood-clotting protein modified for people with hard-to-treat hemophilia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
(Date:12/25/2014)... The microscopy market is estimated to grow at ... by 2019. Optical microscopy is the largest segment ... segment is expected to show the fastest growth ... nanotechnology, technological advancements, and increasing federal support to ... Full Copy of Report @ http://www.marketsandmarkets.com/Market-Reports/world-microscopy-399.html ...
(Date:12/25/2014)... 25, 2014 Product liability lawsuits filed ... recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in ... Order issued in the U.S. District Court, Northern District ... an open conference on January 7, 2015, at the ... in West Palm Beach, Florida. The Conference is scheduled ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Recently, ... discounts on all its wedding dresses. BellasDress has chosen ... more for gift choices for the holiday season. ... can pick suitable wedding gowns here at discount prices. ... shopping experience at its website. , “All ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... children with complex chronic illnesses can receive effective, less expensive ... with easy access to a team of dedicated health care ... to become seriously ill and need either hospitalization or a ... an enhanced medical home clinic at the University of Texas ...
(Date:12/25/2014)... AngelWeddingDress.com tries its best to translate the experience ... business has introduced its new collection of 2015 prom ... The new prom outfits are guaranteed to contain the ... are specially designed for 2015. Anyone who wants to ... its website before Jan. 26, 2015, the deadline of ...
Breaking Medicine News(10 mins):Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2
... ... reform in memory of her brother Eric, reacts to the U. S. Senate’s dramatic passage ... legislation with the House bill before being sent to the President. , ... New York, NY (PRWEB) December 24, 2009 -- ...
... ... Patients have more options, according to Dr. Geoffrey Westrich, co-director of joint replacement research at ... ... advances have revolutionized the way doctors perform hip replacement and knee replacement surgery to relieve ...
... 27, 2009 Ben W. Strowbridge, PhD, associate professor ... a MD/PhD student in the neurosciences graduate program ... are the first to create stimulus-specific sustained activity ... Their study, entitled, "Representing information in cell assemblies: ...
... ... Worldwide (CFW) has launched a 5 year campaign to raise funds internationally to ... Campaign is a unique opportunity for everyone to help support children born with ... 5 US dollars. The CF Worldwide goal is to have 50,000 members join ...
... , SEATTLE, Dec. 25 The following blog post was published ... synthesis blog, winner of the 2008 Weblog award for best ... is a direct correlation between level of education and economic status; ... is a direct correlation between fitness and healthcare cost. There is ...
... occasional treat while sticking to your diet. Here,s how. , FRIDAY, ... chocolate chips you,ve eaten and that box of Santa Claus-shaped candies ... opportunities to overeat and overindulge aren,t over yet. , Before you ... too late to get a handle on your holiday eating. , ...
Cached Medicine News:Health News:A Christmas Gift for Eric: Senate Approves Health Care Bill in Historic Christmas Eve Vote 2Health News:Medical Advances Revolutionize Hip Replacement and Knee Replacement 2Health News:Medical Advances Revolutionize Hip Replacement and Knee Replacement 3Health News:Neuroscientists at Case Western Reserve University store information in isolated brain tissue 2Health News:Neuroscientists at Case Western Reserve University store information in isolated brain tissue 3Health News:Cystic Fibrosis Worldwide Launches a New Campaign to Reach Thousands Who Suffer from CF 2Health News:Cystic Fibrosis Worldwide Launches a New Campaign to Reach Thousands Who Suffer from CF 3Health News:Eat Up, But Eat Healthy This Holiday Season 2
(Date:12/24/2014)... 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... proud to announce Jennifer Hagerman , Pharm.D., AE-C, ... take office as the president of the Michigan Pharmacists ... will take place Feb. 28, 2015, at the MPA ... the Renaissance Center in Detroit, Michigan ...
(Date:12/24/2014)... Dec. 23, 2014  Advanced Medical Isotope Corporation ... primarily in the development of brachytherapy devices and ... announced that it has filed a de ... Administration ("FDA") for marketing clearance for its patented ... the U.S. Food, Drug and Cosmetic Act (the ...
(Date:12/24/2014)... DALLAS , Dec. 23, 2014  Lockton ... operation of Lockton Companies, announced the addition of ... Foerster will join Lockton Dunning,s Pharmacy Consulting team, ... years of relevant industry experience to the position.  ... Managed Market Sales at Diplomat Specialty Pharmacy, where ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Kim Foerster Joins Lockton Companies 2
Castroviejo colibri tying forceps with 5 mm tips and 5 mm titanium coated platforms. Length 110 mm....
Tennant straight tying forceps with extra delicate smooth jaws, 6 mm tying platform, For 9-0 to 11-0 sutures. Overall length 108 mm....
Kelman - McPherson angled tying forceps is long with tying platform 10 mm, serrated handle and polished finish....
Castroviejo tying forceps, straight....
Medicine Products: