Navigation Links
Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
Date:11/3/2008

A very difficult-to-treat child leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on. The study, led by researchers at Children's Hospital Boston and the Dana-Farber Cancer Institute, is the cover article in the November 4 issue of Cancer Cell.

While cure rates for the major types of childhood leukemia are now about 80 percent, they are much lower for patients with a subtype of acute lymphoblastic leukemia (ALL) known as MLL-AF4, which accounts for 5 percent of all ALLs but 70 percent of ALLs striking infants. Children with this form of leukemia suffer rapid relapses and have a cure rate of just under 50 percent with chemotherapy.

"MLL-AF4 leukemias are very difficult to treat and in desperate need of new therapeutic approaches," says senior investigator Scott Armstrong, MD, PhD, of Children's and Dana-Farber. Like other other leukemias, the disease leads to abnormally high numbers of immature, dysfunctional white blood cells that crowd out the bone marrow, interfering with its ability to produce healthy blood cells.

The researchers, led by Armstrong, Andrei Krivtsov, PhD and Zhaohui Feng, also of Children's and Dana-Farber, first developed a mouse model of MLL-AF4, which had eluded scientists in the past. They then showed that the abnormal "fusion" protein that characterizes the disease, also known as MLL-AF4, goes to the cell's DNA and causes abnormal modification of one of the histones, "scaffolding" proteins that give chromosomes their shape and help control gene activation. As a result of this epigenetic change, chromosome structure is altered. This jump-starts activity of a diverse group of genes, including some known to be critical in initiating leukemia.

Studying samples from children with MLL-AF4 leukemias, the team made the same observations.
'/>"/>

Contact: Rob Graham
rob.graham@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Tackling Triglycerides: 8 Ways to Solve a Big Fat Problem, From the Harvard Heart Letter
2. Lack of political will and the subordination of women are major barriers to tackling AIDS
3. Southern California Parents and Kids Take Healthy Steps in Tackling Childhood Obesity
4. Public Health Leaders Unveil Blueprint for Tackling Climate Change
5. Tackling depression in cancer patients can extend life
6. Experts to share how research is tackling cancer
7. Tackling Obesity Through Education and FUNdraising
8. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
9. Revolutionary New Technique Uses Onyx to Fill Hard-To-Treat Aneurysms
10. Relaxation training may improve control of hard-to-treat systolic hypertension
11. Blood-clotting protein modified for people with hard-to-treat hemophilia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
(Date:10/22/2014)... The United States is now mandating that all ... Africa land at one of five airports equipped ... In a statement released Tuesday, Homeland Security ... air passengers from Guinea, Liberia and Sierra Leone ... -- New York City,s Kennedy International Airport, Washington ...
(Date:10/22/2014)... 2014 During the Western United States’ ... runs dangerously low, Southern Oregon’s water is proving resistant ... the lowest mountain snow pack on record in 2014, ... early autumn.* That was the observation of journalist-hikers Art ... “Hiking Southern Oregon,” during an interview with water advocate ...
(Date:10/22/2014)... Lintelus, Inc., an event software provider, ... Sales, will be speaking on the subject of “Event ... October 28, at the Holiday Inn in New York ... well as a Tech Demo at 12:45pm, to educate ... more engaging event experience. , The Annual Meetings Technology ...
(Date:10/22/2014)... Two sisters in high school have developed ways to ... Krishen use electronic stethoscopes, which electronically amplify body sounds, ... or heartbeats. Ilina, a senior at Port Huron ... way to detect early lung damage in people exposed ... recorded one breath cycle each from 16 smokers, 25 ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... was diagnosed with Ebola while working for NBC News ... leave the special isolation unit at Nebraska Medical Center in Omaha, ... hospital said Tuesday. A blood test confirmed by the U.S. ... can head home to Providence, R.I., NBC News reported ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... (HealthDay News) -- A treatment currently being studied may ... build-up of plaque in artery walls that can lead ... conducting the study, published in the Sept. 12 issue ... with atherosclerosis who were randomly assigned to be treated ...
... Depression to Their Physicians , Many adults subscribe to ... to their primary care physician. In a survey of ... more reasons for not talking to a primary care ... reason being concern the physician would recommend antidepressants (23 ...
... HealthDay Reporter , MONDAY, Sept. 12 (HealthDay News) ... men become fathers, perhaps because they don,t need to compete ... bonding with their children. The findings don,t prove that ... the hormonal systems in men may detect that they,ve become ...
... new, minimally invasive way of treating irregular heartbeats by ... one such heart rhythm disorder, and it,s the most ... 70 percent of patients with the disorder who were ... of any heart rhythm irregularities one year out from ...
... By Dennis Thompson HealthDay Reporter , MONDAY, Sept. ... to check for colon cancer will become the standard screening ... slam-dunk. The method, known as virtual colonoscopy, combines X-ray ... length of the colon, the large intestine. It allows doctors ...
... Steven Reinberg HealthDay Reporter , MONDAY, Sept. 12 ... (NSAIDs) such as Advil, Motrin and Aleve may slightly increase ... Millions of people use these drugs regularly for pain and ... cancers, the researchers added. "NSAIDs have been associated ...
Cached Medicine News:Health News:New Drug Boosts 'Good' Cholesterol in Study Patients 2Health News:September/October 2011 Annals of Family Medicine Tip Sheet 2Health News:September/October 2011 Annals of Family Medicine Tip Sheet 3Health News:September/October 2011 Annals of Family Medicine Tip Sheet 4Health News:September/October 2011 Annals of Family Medicine Tip Sheet 5Health News:September/October 2011 Annals of Family Medicine Tip Sheet 6Health News:September/October 2011 Annals of Family Medicine Tip Sheet 7Health News:September/October 2011 Annals of Family Medicine Tip Sheet 8Health News:Testosterone Levels Seem to Fall With Fatherhood 2Health News:Testosterone Levels Seem to Fall With Fatherhood 3Health News:Freeze and desist: Disabling cardiac cells that can cause arrhythmia 2Health News:Virtual Colonoscopy Still Has Its Skeptics 2Health News:Virtual Colonoscopy Still Has Its Skeptics 3Health News:Virtual Colonoscopy Still Has Its Skeptics 4Health News:NSAID Painkillers Linked to Risk of Kidney Cancer 2Health News:NSAID Painkillers Linked to Risk of Kidney Cancer 3
(Date:10/22/2014)... , October 22, 2014 Investor-Edge ... Inc. (NASDAQ: FOLD ), Progenics Pharmaceuticals Inc. ... THLD ), Idera Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... 21, 2014, the NASDAQ Composite ended at 4,419.48, up ...
(Date:10/22/2014)... Oct. 22, 2014   Reproductive Medicine Associates ... in the field of infertility, presents new clinical ... screening. The research abstract, released during the 70 ... (ASRM) meeting in Honolulu, Hawaii ... gene defect (SGD) pre-implantation genetic diagnosis (PGD). ...
(Date:10/22/2014)... -- AVACEN Medical announced today that its AVACEN 100 ... by the U.S. Food and Drug Administration. This clearance ... Internet for: the temporary relief of joint pain ... sprains . Logo - http://photos.prnewswire.com/prnh/20141021/153513 ... a sophisticated medical device incorporating over 3,000 firmware instructions ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... Technology Co., Ltd, one of the leading manufacturers of medical ... machine. Noble Laser,s IPL machine always enjoys a ... world choose this machine because of high configuration, stable quality ... free choosing. Please log in to www.noblelaser.com to ...
...  The Preserve Community Pharmacy Access NOW! (PCPAN) coalition today applauded ... the proposed merger between Express Scripts, Inc. (ESI) and ... In a letter to the Federal Trade Commission (FTC), ... 100,000 active and retired union mine workers. ...
Cached Medicine Technology:Beijing Noble Laser Technology Co., Ltd Offers a Great Deal on its IPL Machine 2Nationwide Coalition Applauds United Mine Workers For Voicing Concern Over Proposed ESI/Medco Merger 2
Angulated, blunt and pointed tips....
Pointed, 12 cm long....
All Bovie LLETZ Loop and Square electrodes feature tungsten wire for superior shape and integrity throughout the excision procedure. They use a standard 3/32" (2.3 mm) shaft....
Disposable 1 1/4" Tungsten Micro Needle, Ins., Straight...
Medicine Products: