Navigation Links
TSRI scientists catch misguided DNA-repair proteins in the act
Date:5/22/2014

LA JOLLA, CA May 22, 2014 Accumulation of DNA damage can cause aggressive forms of cancer and accelerated aging, so the body's DNA repair mechanisms are normally key to good health. However, in some diseases the DNA repair machinery can become harmful. Scientists led by a group of researchers at The Scripps Research Institute (TSRI) in La Jolla, CA, have discovered some of the key proteins involved in one type of DNA repair gone awry.

The focus of the new study, published in the May 22, 2014 edition of the journal Cell Reports, is a protein called Ring1b. The TSRI researchers found that Ring1b promotes fusion between telomeresrepetitive sequences of DNA that act as bumpers on the ends of chromosomes and protect important genetic information. The scientists also showed inhibiting this protein can significantly reduce the burden on cells affected by such telomere dysfunction.

"We are very far from therapy, but I think a lot of the factors we've identified could play key roles in processing dysfunctional telomeres, a key event in tumorigenesis [cancer initiation]," said Eros Lazzerini Denchi, assistant professor at TSRI who led the study.

The Trouble with Telomeres

Humans are born with long telomeres, but these become shorter every time a cell in the body divides. With age, telomeres become very short, especially in tissues that have high proliferation rate.

That's when the problems start. When telomeres become too short, they lose their telomere protective cap and become recognized by the DNA repair machinery proteins. This can lead to the fusion of chromosomes "end-to-end" into a string-like formation.

Joined chromosomes represent an abnormal genomic arrangement that is extremely unstable in dividing cells. Upon cell division, joined chromosomes can rupture, creating new break points that can further re-engage aberrant DNA repair. These cycles of fusion and breakage cause a rampant level
'/>"/>

Contact: Madeline McCurry Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists seek answers with space station thyroid cancer study
2. MIPT scientists develop algorithm for anti-aging remedy search
3. Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug
4. Scientists slow brain tumor growth in mice
5. UBC scientists find new way to mobilize immune system against viruses
6. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
7. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
8. Scientists identify new protein in the neurological disorder dystonia
9. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
10. Norwegian neuroscientists elected to National Academy of Sciences
11. NIH scientists establish monkey model of hantavirus disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
TSRI scientists catch misguided DNA-repair proteins in the act
(Date:9/1/2015)... ... ... Celebrity hairstylist and Beauty Gives Back Art Team member Ted Gibson in ... Oct. 1, at the La Valencia Hotel. The presentation, on the eve of Fashion ... professional hair, makeup and nail design. , The evening of beauty and fashion ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... aid colleges and universities across the country in stemming sexual assaults on their ... Climate Collaborative (ARC3), a consortium of sexual assault researchers and student affairs professionals ...
(Date:9/1/2015)... ... September 01, 2015 , ... Splashtop Inc. , the ... Support , a solution optimized for MSPs and IT professionals looking for a ... and inadequate customer services of existing remote support solution, many MSPs and ITs ...
(Date:9/1/2015)... ... September 01, 2015 , ... OncLive® ... hospital by U.S. News & World Report, to provide breaking news and information ... and marketing groups within OncLive, which provides oncologists resources and information?they need to ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... With former ... Engineering and Math) disciplines since its inception more than 35 years ago. A pilot ... students and their teachers - and, not just those intent on pursuing careers in ...
Breaking Medicine News(10 mins):Health News:Celebrity Hairstylist Ted Gibson Explores Fusion of Fashion and Beauty at “Beauty Behind the Fashion” at Fashion Week San Diego Proceeds to benefit THIRST Project 2Health News:Celebrity Hairstylist Ted Gibson Explores Fusion of Fashion and Beauty at “Beauty Behind the Fashion” at Fashion Week San Diego Proceeds to benefit THIRST Project 3Health News:Georgia State, Partners Introduce Climate Survey to Aid in Preventing Campus Sexual Assaults 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 4Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 2Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 3Health News:Inmar Announces Program to Fuel Student Passion for STEM – with an Unconventional Twist 2
... Jo-Anne Leese of Cheshire will be refunded ?6000 the amount ... breast cancer treatment.// The amount is to be refunded by ... her treatment. , ,Mrs. Leese got her claims cleared ... provided to patients who wanted Herceptin anti-cancer drug treatment as ...
... A new study reveals that antibiotics if taken limitlessly ... more than 10 times during childhood can increase the ... lymphatic system. , The study, conducted by Ellen ... Centre in Fremont, also found heavy use of non-steroidal ...
... from the Salk Institute for Biological Studies have suggested ... replication is essential for recruiting the //processing machinery that ... ,Telomeres, the ends of linear chromosomes, represent a problem ... damage machinery. An exposed telomere could readily be taken ...
... of people with autism may display autistic brain differences and ... suffer from the disorder themselves. //, ,The ... the annual meeting of the Society of Neuroscience, in Washington ... in Denver, USA. , ,Autism, which affects ...
... Delhi will play host to 800 women from 55 ... Women from November 27. // ,The four-day international ... held for the first time in South Asia. The ... Janeiro (1999) and Stockholm (2002)., ,Among its main ...
... a baby can be detected by his or her eye ... same.// ,Professor Chris Harris, from the University of Plymouth, ... patient's head to see how "flicks" of the eye are ... BBC News. , ,The scientist said: 'The way we ...
Cached Medicine News:Health News:Chromosome Ends Trigger DNA Damage Response For Telomere Protection, 2Health News:Delhi To Host International Women’s Congress From Nov 2 2
(Date:9/1/2015)... Sept. 1, 2015  AccuTec Blades, Inc. today announced ... Blades division.  EPC announced in May 2015 its intent ... Verona, Virginia and Obregon, Mexico ... sale process. Rick Gagliano , ... Blades said, "Our new name, AccuTec Blades, reflects the ...
(Date:9/1/2015)... --NOWDiagnostics Inc., based in Springdale, Ark. , ... Canada , a move that brings the company ... have greater access to information concerning their health. ... blood-based rapid tests that allow health care providers to ... ailments and diseases. ZBx Corporation, a Toronto ...
(Date:9/1/2015)... DALLAS , Sept. 1, 2015 UT ... and distinguished faculty members joined U.S. Representatives ... in a roundtable discussion on the 21 st ... biomedical research currently being considered by the ... faculty – including National Academy of Sciences members, department ...
Breaking Medicine Technology:AccuTec Blades, Inc. Announces Acquisition of Industrial Blades Division from Edgewell Personal Care Company 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 4U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 5
... Conn., May 15, 2012 /PRNewswire-iReach/ -- Global ... important Cambridge Healthtech Institute conferences: IMVACS – ... August 13 – 15, Cambridge, MA - The ... under one heading: the Seventh Annual Novel Vaccines, Design ...
... Labs, Inc. (OTCQB/OTCBB: GOVX), a biotechnology company that creates, ... results for the three months ended March 31, 2012 ... delighted with recent developments that have strengthened and advanced ... David Dodd. "Our Phase 1/2 therapeutic vaccine trial continues ...
Cached Medicine Technology:Attendees Save up to $350 on CHI Conferences This Summer by Registering Through Global Information 2GeoVax Labs Reports 2012 First Quarter Financial Results 2GeoVax Labs Reports 2012 First Quarter Financial Results 3GeoVax Labs Reports 2012 First Quarter Financial Results 4GeoVax Labs Reports 2012 First Quarter Financial Results 5GeoVax Labs Reports 2012 First Quarter Financial Results 6
Straight shafts with 0.12 mm teeth and tying platform. Serrated handle with polished finish....
Angled 45 degree shafts with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Heavy curved shafts with 2 x 2 teeth and crisscross serrated 6 mm tying platform. Serrated handle with polished finish....
Straight shafts with 1 x 2 teeth and 6 mm tying platform. Wide serrated handle with polished finish....
Medicine Products: